6U96
Actin phalloidin at BeFx state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0001725 | cellular_component | stress fiber |
| A | 0003785 | molecular_function | actin monomer binding |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005523 | molecular_function | tropomyosin binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005865 | cellular_component | striated muscle thin filament |
| A | 0005884 | cellular_component | actin filament |
| A | 0010628 | biological_process | positive regulation of gene expression |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0030027 | cellular_component | lamellipodium |
| A | 0030041 | biological_process | actin filament polymerization |
| A | 0030175 | cellular_component | filopodium |
| A | 0030240 | biological_process | skeletal muscle thin filament assembly |
| A | 0031013 | molecular_function | troponin I binding |
| A | 0031432 | molecular_function | titin binding |
| A | 0031941 | cellular_component | filamentous actin |
| A | 0032036 | molecular_function | myosin heavy chain binding |
| A | 0032432 | cellular_component | actin filament bundle |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044297 | cellular_component | cell body |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0048741 | biological_process | skeletal muscle fiber development |
| A | 0051017 | biological_process | actin filament bundle assembly |
| A | 0090131 | biological_process | mesenchyme migration |
| A | 0098723 | cellular_component | skeletal muscle myofibril |
| A | 0140660 | molecular_function | cytoskeletal motor activator activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0001725 | cellular_component | stress fiber |
| B | 0003785 | molecular_function | actin monomer binding |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005523 | molecular_function | tropomyosin binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005865 | cellular_component | striated muscle thin filament |
| B | 0005884 | cellular_component | actin filament |
| B | 0010628 | biological_process | positive regulation of gene expression |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019904 | molecular_function | protein domain specific binding |
| B | 0030027 | cellular_component | lamellipodium |
| B | 0030041 | biological_process | actin filament polymerization |
| B | 0030175 | cellular_component | filopodium |
| B | 0030240 | biological_process | skeletal muscle thin filament assembly |
| B | 0031013 | molecular_function | troponin I binding |
| B | 0031432 | molecular_function | titin binding |
| B | 0031941 | cellular_component | filamentous actin |
| B | 0032036 | molecular_function | myosin heavy chain binding |
| B | 0032432 | cellular_component | actin filament bundle |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0044297 | cellular_component | cell body |
| B | 0048306 | molecular_function | calcium-dependent protein binding |
| B | 0048741 | biological_process | skeletal muscle fiber development |
| B | 0051017 | biological_process | actin filament bundle assembly |
| B | 0090131 | biological_process | mesenchyme migration |
| B | 0098723 | cellular_component | skeletal muscle myofibril |
| B | 0140660 | molecular_function | cytoskeletal motor activator activity |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0001725 | cellular_component | stress fiber |
| C | 0003785 | molecular_function | actin monomer binding |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005523 | molecular_function | tropomyosin binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005856 | cellular_component | cytoskeleton |
| C | 0005865 | cellular_component | striated muscle thin filament |
| C | 0005884 | cellular_component | actin filament |
| C | 0010628 | biological_process | positive regulation of gene expression |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0019904 | molecular_function | protein domain specific binding |
| C | 0030027 | cellular_component | lamellipodium |
| C | 0030041 | biological_process | actin filament polymerization |
| C | 0030175 | cellular_component | filopodium |
| C | 0030240 | biological_process | skeletal muscle thin filament assembly |
| C | 0031013 | molecular_function | troponin I binding |
| C | 0031432 | molecular_function | titin binding |
| C | 0031941 | cellular_component | filamentous actin |
| C | 0032036 | molecular_function | myosin heavy chain binding |
| C | 0032432 | cellular_component | actin filament bundle |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0044297 | cellular_component | cell body |
| C | 0048306 | molecular_function | calcium-dependent protein binding |
| C | 0048741 | biological_process | skeletal muscle fiber development |
| C | 0051017 | biological_process | actin filament bundle assembly |
| C | 0090131 | biological_process | mesenchyme migration |
| C | 0098723 | cellular_component | skeletal muscle myofibril |
| C | 0140660 | molecular_function | cytoskeletal motor activator activity |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0001725 | cellular_component | stress fiber |
| D | 0003785 | molecular_function | actin monomer binding |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005523 | molecular_function | tropomyosin binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005856 | cellular_component | cytoskeleton |
| D | 0005865 | cellular_component | striated muscle thin filament |
| D | 0005884 | cellular_component | actin filament |
| D | 0010628 | biological_process | positive regulation of gene expression |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0019904 | molecular_function | protein domain specific binding |
| D | 0030027 | cellular_component | lamellipodium |
| D | 0030041 | biological_process | actin filament polymerization |
| D | 0030175 | cellular_component | filopodium |
| D | 0030240 | biological_process | skeletal muscle thin filament assembly |
| D | 0031013 | molecular_function | troponin I binding |
| D | 0031432 | molecular_function | titin binding |
| D | 0031941 | cellular_component | filamentous actin |
| D | 0032036 | molecular_function | myosin heavy chain binding |
| D | 0032432 | cellular_component | actin filament bundle |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0044297 | cellular_component | cell body |
| D | 0048306 | molecular_function | calcium-dependent protein binding |
| D | 0048741 | biological_process | skeletal muscle fiber development |
| D | 0051017 | biological_process | actin filament bundle assembly |
| D | 0090131 | biological_process | mesenchyme migration |
| D | 0098723 | cellular_component | skeletal muscle myofibril |
| D | 0140660 | molecular_function | cytoskeletal motor activator activity |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0001725 | cellular_component | stress fiber |
| E | 0003785 | molecular_function | actin monomer binding |
| E | 0005509 | molecular_function | calcium ion binding |
| E | 0005515 | molecular_function | protein binding |
| E | 0005523 | molecular_function | tropomyosin binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005856 | cellular_component | cytoskeleton |
| E | 0005865 | cellular_component | striated muscle thin filament |
| E | 0005884 | cellular_component | actin filament |
| E | 0010628 | biological_process | positive regulation of gene expression |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0019904 | molecular_function | protein domain specific binding |
| E | 0030027 | cellular_component | lamellipodium |
| E | 0030041 | biological_process | actin filament polymerization |
| E | 0030175 | cellular_component | filopodium |
| E | 0030240 | biological_process | skeletal muscle thin filament assembly |
| E | 0031013 | molecular_function | troponin I binding |
| E | 0031432 | molecular_function | titin binding |
| E | 0031941 | cellular_component | filamentous actin |
| E | 0032036 | molecular_function | myosin heavy chain binding |
| E | 0032432 | cellular_component | actin filament bundle |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0044297 | cellular_component | cell body |
| E | 0048306 | molecular_function | calcium-dependent protein binding |
| E | 0048741 | biological_process | skeletal muscle fiber development |
| E | 0051017 | biological_process | actin filament bundle assembly |
| E | 0090131 | biological_process | mesenchyme migration |
| E | 0098723 | cellular_component | skeletal muscle myofibril |
| E | 0140660 | molecular_function | cytoskeletal motor activator activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue ADP A 801 |
| Chain | Residue |
| A | GLY13 |
| A | SER14 |
| A | GLY156 |
| A | ASP157 |
| A | LYS213 |
| A | GLU214 |
| A | GLY302 |
| A | TYR306 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue ADP B 801 |
| Chain | Residue |
| B | SER14 |
| B | GLY156 |
| B | ASP157 |
| B | LYS213 |
| B | GLU214 |
| B | GLY302 |
| B | TYR306 |
| B | GLY13 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue ADP C 401 |
| Chain | Residue |
| C | GLY13 |
| C | SER14 |
| C | GLY156 |
| C | ASP157 |
| C | LYS213 |
| C | GLU214 |
| C | GLY302 |
| C | TYR306 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue ADP D 801 |
| Chain | Residue |
| D | GLY13 |
| D | SER14 |
| D | GLY156 |
| D | ASP157 |
| D | LYS213 |
| D | GLU214 |
| D | GLY302 |
| D | TYR306 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue ADP E 401 |
| Chain | Residue |
| E | GLY13 |
| E | SER14 |
| E | GLY156 |
| E | ASP157 |
| E | LYS213 |
| E | GLU214 |
| E | GLY302 |
| E | TYR306 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide EEP F 1 and TRP F 7 |
| Chain | Residue |
| A | GLY197 |
| B | PRO112 |
| F | ALA2 |
| F | CYS4 |
| F | HYP5 |
| F | ALA6 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide EEP F 1 and ALA F 2 |
| Chain | Residue |
| A | GLY197 |
| F | ALO3 |
| F | TRP7 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide ALA F 2 and ALO F 3 |
| Chain | Residue |
| A | SER199 |
| F | EEP1 |
| F | CYS4 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide ALO F 3 and CYS F 4 |
| Chain | Residue |
| A | SER199 |
| F | ALA2 |
| F | HYP5 |
| F | ALA6 |
| F | TRP7 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide CYS F 4 and HYP F 5 |
| Chain | Residue |
| F | ALO3 |
| F | ALA6 |
| F | TRP7 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide HYP F 5 and ALA F 6 |
| Chain | Residue |
| B | GLU72 |
| F | CYS4 |
| F | TRP7 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide EEP G 1 and TRP G 7 |
| Chain | Residue |
| B | GLY197 |
| D | PRO112 |
| G | ALA2 |
| G | CYS4 |
| G | HYP5 |
| G | ALA6 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for Di-peptide EEP G 1 and ALA G 2 |
| Chain | Residue |
| B | GLY197 |
| B | TYR198 |
| G | ALO3 |
| G | TRP7 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide ALA G 2 and ALO G 3 |
| Chain | Residue |
| B | GLY197 |
| B | TYR198 |
| B | SER199 |
| G | EEP1 |
| G | CYS4 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide ALO G 3 and CYS G 4 |
| Chain | Residue |
| B | SER199 |
| G | ALA2 |
| G | HYP5 |
| G | ALA6 |
| G | TRP7 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide CYS G 4 and HYP G 5 |
| Chain | Residue |
| G | ALO3 |
| G | ALA6 |
| G | TRP7 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide HYP G 5 and ALA G 6 |
| Chain | Residue |
| D | GLU72 |
| G | CYS4 |
| G | TRP7 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide EEP H 1 and TRP H 7 |
| Chain | Residue |
| A | PRO112 |
| C | GLY197 |
| H | ALA2 |
| H | CYS4 |
| H | HYP5 |
| H | ALA6 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide EEP H 1 and ALA H 2 |
| Chain | Residue |
| C | GLY197 |
| H | ALO3 |
| H | TRP7 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide ALA H 2 and ALO H 3 |
| Chain | Residue |
| H | EEP1 |
| H | CYS4 |
| C | SER199 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide ALO H 3 and CYS H 4 |
| Chain | Residue |
| C | SER199 |
| H | ALA2 |
| H | HYP5 |
| H | ALA6 |
| H | TRP7 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide CYS H 4 and HYP H 5 |
| Chain | Residue |
| H | ALO3 |
| H | ALA6 |
| H | TRP7 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide HYP H 5 and ALA H 6 |
| Chain | Residue |
| A | GLU72 |
| H | CYS4 |
| H | TRP7 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide EEP I 1 and ALA I 2 |
| Chain | Residue |
| E | GLY197 |
| I | ALO3 |
| I | TRP7 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide EEP I 1 and TRP I 7 |
| Chain | Residue |
| C | PRO112 |
| E | GLY197 |
| I | ALA2 |
| I | CYS4 |
| I | HYP5 |
| I | ALA6 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide ALA I 2 and ALO I 3 |
| Chain | Residue |
| E | SER199 |
| I | EEP1 |
| I | CYS4 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide ALO I 3 and CYS I 4 |
| Chain | Residue |
| E | SER199 |
| I | ALA2 |
| I | HYP5 |
| I | ALA6 |
| I | TRP7 |
| site_id | AF1 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide CYS I 4 and HYP I 5 |
| Chain | Residue |
| I | ALO3 |
| I | ALA6 |
| I | TRP7 |
| site_id | AF2 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide HYP I 5 and ALA I 6 |
| Chain | Residue |
| C | GLU72 |
| I | CYS4 |
| I | TRP7 |
| site_id | AF3 |
| Number of Residues | 2 |
| Details | binding site for Di-peptide EEP J 1 and ALA J 2 |
| Chain | Residue |
| J | ALO3 |
| J | TRP7 |
| site_id | AF4 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide EEP J 1 and TRP J 7 |
| Chain | Residue |
| E | PRO112 |
| J | ALA2 |
| J | CYS4 |
| J | HYP5 |
| J | ALA6 |
| site_id | AF5 |
| Number of Residues | 2 |
| Details | binding site for Di-peptide ALA J 2 and ALO J 3 |
| Chain | Residue |
| J | EEP1 |
| J | CYS4 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for Di-peptide ALO J 3 and CYS J 4 |
| Chain | Residue |
| J | ALA2 |
| J | HYP5 |
| J | ALA6 |
| J | TRP7 |
| site_id | AF7 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide CYS J 4 and HYP J 5 |
| Chain | Residue |
| J | ALO3 |
| J | ALA6 |
| J | TRP7 |
| site_id | AF8 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide HYP J 5 and ALA J 6 |
| Chain | Residue |
| E | GLU72 |
| J | CYS4 |
| J | TRP7 |
Functional Information from PROSITE/UniProt
| site_id | PS00406 |
| Number of Residues | 11 |
| Details | ACTINS_1 Actins signature 1. YVGDEAQs.KRG |
| Chain | Residue | Details |
| A | TYR53-GLY63 |
| site_id | PS00432 |
| Number of Residues | 9 |
| Details | ACTINS_2 Actins signature 2. WITKqEYDE |
| Chain | Residue | Details |
| A | TRP356-GLU364 |
| site_id | PS01132 |
| Number of Residues | 13 |
| Details | ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR |
| Chain | Residue | Details |
| A | LEU104-ARG116 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | MOD_RES: N-acetylcysteine; in intermediate form => ECO:0000250|UniProtKB:P62737 |
| Chain | Residue | Details |
| A | CYS0 | |
| B | CYS0 | |
| C | CYS0 | |
| D | CYS0 | |
| E | CYS0 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | MOD_RES: N-acetylaspartate; in Actin, alpha skeletal muscle => ECO:0000269|PubMed:1150665 |
| Chain | Residue | Details |
| A | ASP1 | |
| B | ASP1 | |
| C | ASP1 | |
| D | ASP1 | |
| E | ASP1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | MOD_RES: Methionine (R)-sulfoxide => ECO:0000250|UniProtKB:P68134 |
| Chain | Residue | Details |
| A | MET44 | |
| E | MET47 | |
| A | MET47 | |
| B | MET44 | |
| B | MET47 | |
| C | MET44 | |
| C | MET47 | |
| D | MET44 | |
| D | MET47 | |
| E | MET44 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | MOD_RES: N6-malonyllysine => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS61 | |
| B | LYS61 | |
| C | LYS61 | |
| D | LYS61 | |
| E | LYS61 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | MOD_RES: Tele-methylhistidine => ECO:0000269|PubMed:1150665, ECO:0000269|PubMed:16905096, ECO:0000269|PubMed:213279, ECO:0000269|PubMed:2395459, ECO:0000269|PubMed:499690, ECO:0007744|PDB:1ATN, ECO:0007744|PDB:1NWK |
| Chain | Residue | Details |
| A | HIC73 | |
| B | HIC73 | |
| C | HIC73 | |
| D | HIC73 | |
| E | HIC73 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | MOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:P68133 |
| Chain | Residue | Details |
| A | LYS84 | |
| B | LYS84 | |
| C | LYS84 | |
| D | LYS84 | |
| E | LYS84 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | MOD_RES: ADP-ribosylarginine; by SpvB => ECO:0000305|PubMed:16905096 |
| Chain | Residue | Details |
| A | ARG177 | |
| B | ARG177 | |
| C | ARG177 | |
| D | ARG177 | |
| E | ARG177 |
