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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6U7M

Cryo-EM Structure of Helical Lipoprotein Lipase

Functional Information from GO Data
ChainGOidnamespacecontents
A0004465molecular_functionlipoprotein lipase activity
A0006629biological_processlipid metabolic process
A0016298molecular_functionlipase activity
A0052689molecular_functioncarboxylic ester hydrolase activity
B0004465molecular_functionlipoprotein lipase activity
B0006629biological_processlipid metabolic process
B0016298molecular_functionlipase activity
B0052689molecular_functioncarboxylic ester hydrolase activity
C0004465molecular_functionlipoprotein lipase activity
C0006629biological_processlipid metabolic process
C0016298molecular_functionlipase activity
C0052689molecular_functioncarboxylic ester hydrolase activity
D0004465molecular_functionlipoprotein lipase activity
D0006629biological_processlipid metabolic process
D0016298molecular_functionlipase activity
D0052689molecular_functioncarboxylic ester hydrolase activity
E0004465molecular_functionlipoprotein lipase activity
E0006629biological_processlipid metabolic process
E0016298molecular_functionlipase activity
E0052689molecular_functioncarboxylic ester hydrolase activity
F0004465molecular_functionlipoprotein lipase activity
F0006629biological_processlipid metabolic process
F0016298molecular_functionlipase activity
F0052689molecular_functioncarboxylic ester hydrolase activity
G0004465molecular_functionlipoprotein lipase activity
G0006629biological_processlipid metabolic process
G0016298molecular_functionlipase activity
G0052689molecular_functioncarboxylic ester hydrolase activity
H0004465molecular_functionlipoprotein lipase activity
H0006629biological_processlipid metabolic process
H0016298molecular_functionlipase activity
H0052689molecular_functioncarboxylic ester hydrolase activity
I0004465molecular_functionlipoprotein lipase activity
I0006629biological_processlipid metabolic process
I0016298molecular_functionlipase activity
I0052689molecular_functioncarboxylic ester hydrolase activity
J0004465molecular_functionlipoprotein lipase activity
J0006629biological_processlipid metabolic process
J0016298molecular_functionlipase activity
J0052689molecular_functioncarboxylic ester hydrolase activity
K0004465molecular_functionlipoprotein lipase activity
K0006629biological_processlipid metabolic process
K0016298molecular_functionlipase activity
K0052689molecular_functioncarboxylic ester hydrolase activity
L0004465molecular_functionlipoprotein lipase activity
L0006629biological_processlipid metabolic process
L0016298molecular_functionlipase activity
L0052689molecular_functioncarboxylic ester hydrolase activity
M0004465molecular_functionlipoprotein lipase activity
M0006629biological_processlipid metabolic process
M0016298molecular_functionlipase activity
M0052689molecular_functioncarboxylic ester hydrolase activity
N0004465molecular_functionlipoprotein lipase activity
N0006629biological_processlipid metabolic process
N0016298molecular_functionlipase activity
N0052689molecular_functioncarboxylic ester hydrolase activity
O0004465molecular_functionlipoprotein lipase activity
O0006629biological_processlipid metabolic process
O0016298molecular_functionlipase activity
O0052689molecular_functioncarboxylic ester hydrolase activity
P0004465molecular_functionlipoprotein lipase activity
P0006629biological_processlipid metabolic process
P0016298molecular_functionlipase activity
P0052689molecular_functioncarboxylic ester hydrolase activity
Q0004465molecular_functionlipoprotein lipase activity
Q0006629biological_processlipid metabolic process
Q0016298molecular_functionlipase activity
Q0052689molecular_functioncarboxylic ester hydrolase activity
R0004465molecular_functionlipoprotein lipase activity
R0006629biological_processlipid metabolic process
R0016298molecular_functionlipase activity
R0052689molecular_functioncarboxylic ester hydrolase activity
S0004465molecular_functionlipoprotein lipase activity
S0006629biological_processlipid metabolic process
S0016298molecular_functionlipase activity
S0052689molecular_functioncarboxylic ester hydrolase activity
T0004465molecular_functionlipoprotein lipase activity
T0006629biological_processlipid metabolic process
T0016298molecular_functionlipase activity
T0052689molecular_functioncarboxylic ester hydrolase activity
U0004465molecular_functionlipoprotein lipase activity
U0006629biological_processlipid metabolic process
U0016298molecular_functionlipase activity
U0052689molecular_functioncarboxylic ester hydrolase activity
a0004465molecular_functionlipoprotein lipase activity
a0006629biological_processlipid metabolic process
a0016298molecular_functionlipase activity
a0052689molecular_functioncarboxylic ester hydrolase activity
b0004465molecular_functionlipoprotein lipase activity
b0006629biological_processlipid metabolic process
b0016298molecular_functionlipase activity
b0052689molecular_functioncarboxylic ester hydrolase activity
c0004465molecular_functionlipoprotein lipase activity
c0006629biological_processlipid metabolic process
c0016298molecular_functionlipase activity
c0052689molecular_functioncarboxylic ester hydrolase activity
d0004465molecular_functionlipoprotein lipase activity
d0006629biological_processlipid metabolic process
d0016298molecular_functionlipase activity
d0052689molecular_functioncarboxylic ester hydrolase activity
e0004465molecular_functionlipoprotein lipase activity
e0006629biological_processlipid metabolic process
e0016298molecular_functionlipase activity
e0052689molecular_functioncarboxylic ester hydrolase activity
f0004465molecular_functionlipoprotein lipase activity
f0006629biological_processlipid metabolic process
f0016298molecular_functionlipase activity
f0052689molecular_functioncarboxylic ester hydrolase activity
g0004465molecular_functionlipoprotein lipase activity
g0006629biological_processlipid metabolic process
g0016298molecular_functionlipase activity
g0052689molecular_functioncarboxylic ester hydrolase activity
h0004465molecular_functionlipoprotein lipase activity
h0006629biological_processlipid metabolic process
h0016298molecular_functionlipase activity
h0052689molecular_functioncarboxylic ester hydrolase activity
i0004465molecular_functionlipoprotein lipase activity
i0006629biological_processlipid metabolic process
i0016298molecular_functionlipase activity
i0052689molecular_functioncarboxylic ester hydrolase activity
Functional Information from PROSITE/UniProt
site_idPS00120
Number of Residues10
DetailsLIPASE_SER Lipases, serine active site. VHLLGYSLGA
ChainResidueDetails
AVAL156-ALA165
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3690
DetailsDomain: {"description":"PLAT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00152","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues120
DetailsRegion: {"description":"Important for interaction with lipoprotein particles","evidences":[{"source":"UniProtKB","id":"P06858","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues120
DetailsRegion: {"description":"Important for heparin binding","evidences":[{"source":"UniProtKB","id":"P06858","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues30
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"P06858","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues60
DetailsActive site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU10037","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues120
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P06858","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues90
DetailsModified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"Q06000","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues60
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"2674142","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues30
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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