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6U5Z

Cryo-EM structure of E. coli LonA S679A

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003677molecular_functionDNA binding
A0004176molecular_functionATP-dependent peptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006508biological_processproteolysis
A0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0009408biological_processresponse to heat
A0010165biological_processresponse to X-ray
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0030163biological_processprotein catabolic process
A0034605biological_processcellular response to heat
A0043565molecular_functionsequence-specific DNA binding
B0000166molecular_functionnucleotide binding
B0003677molecular_functionDNA binding
B0004176molecular_functionATP-dependent peptidase activity
B0004252molecular_functionserine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006508biological_processproteolysis
B0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
B0008233molecular_functionpeptidase activity
B0008236molecular_functionserine-type peptidase activity
B0009408biological_processresponse to heat
B0010165biological_processresponse to X-ray
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0030163biological_processprotein catabolic process
B0034605biological_processcellular response to heat
B0043565molecular_functionsequence-specific DNA binding
C0000166molecular_functionnucleotide binding
C0003677molecular_functionDNA binding
C0004176molecular_functionATP-dependent peptidase activity
C0004252molecular_functionserine-type endopeptidase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006508biological_processproteolysis
C0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
C0008233molecular_functionpeptidase activity
C0008236molecular_functionserine-type peptidase activity
C0009408biological_processresponse to heat
C0010165biological_processresponse to X-ray
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0030163biological_processprotein catabolic process
C0034605biological_processcellular response to heat
C0043565molecular_functionsequence-specific DNA binding
D0000166molecular_functionnucleotide binding
D0003677molecular_functionDNA binding
D0004176molecular_functionATP-dependent peptidase activity
D0004252molecular_functionserine-type endopeptidase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006508biological_processproteolysis
D0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
D0008233molecular_functionpeptidase activity
D0008236molecular_functionserine-type peptidase activity
D0009408biological_processresponse to heat
D0010165biological_processresponse to X-ray
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0030163biological_processprotein catabolic process
D0034605biological_processcellular response to heat
D0043565molecular_functionsequence-specific DNA binding
E0000166molecular_functionnucleotide binding
E0003677molecular_functionDNA binding
E0004176molecular_functionATP-dependent peptidase activity
E0004252molecular_functionserine-type endopeptidase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006508biological_processproteolysis
E0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
E0008233molecular_functionpeptidase activity
E0008236molecular_functionserine-type peptidase activity
E0009408biological_processresponse to heat
E0010165biological_processresponse to X-ray
E0016787molecular_functionhydrolase activity
E0016887molecular_functionATP hydrolysis activity
E0030163biological_processprotein catabolic process
E0034605biological_processcellular response to heat
E0043565molecular_functionsequence-specific DNA binding
F0000166molecular_functionnucleotide binding
F0003677molecular_functionDNA binding
F0004176molecular_functionATP-dependent peptidase activity
F0004252molecular_functionserine-type endopeptidase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006508biological_processproteolysis
F0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
F0008233molecular_functionpeptidase activity
F0008236molecular_functionserine-type peptidase activity
F0009408biological_processresponse to heat
F0010165biological_processresponse to X-ray
F0016787molecular_functionhydrolase activity
F0016887molecular_functionATP hydrolysis activity
F0030163biological_processprotein catabolic process
F0034605biological_processcellular response to heat
F0043565molecular_functionsequence-specific DNA binding
Functional Information from PROSITE/UniProt
site_idPS00178
Number of Residues12
DetailsAA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PgvNDlFTVGTV
ChainResidueDetails
APRO63-VAL74

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1086
DetailsDomain: {"description":"Lon proteolytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU01122","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues6
DetailsActive site: {}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues6
DetailsActive site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01973","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14665623","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues42
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01973","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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