6U5W
Electron cryomicroscopy structure of C. albicans FAS in the KS-stalled state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004312 | molecular_function | fatty acid synthase activity |
| A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| A | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| A | 0004321 | molecular_function | fatty-acyl-CoA synthase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005835 | cellular_component | fatty acid synthase complex |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0008897 | molecular_function | holo-[acyl-carrier-protein] synthase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0042759 | biological_process | long-chain fatty acid biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0101026 | biological_process | mitotic nuclear membrane biogenesis |
| A | 1900535 | biological_process | palmitic acid biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004312 | molecular_function | fatty acid synthase activity |
| B | 0004313 | molecular_function | [acyl-carrier-protein] S-acetyltransferase activity |
| B | 0004314 | molecular_function | [acyl-carrier-protein] S-malonyltransferase activity |
| B | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| B | 0004321 | molecular_function | fatty-acyl-CoA synthase activity |
| B | 0005811 | cellular_component | lipid droplet |
| B | 0005829 | cellular_component | cytosol |
| B | 0005835 | cellular_component | fatty acid synthase complex |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016297 | molecular_function | fatty acyl-[ACP] hydrolase activity |
| B | 0016409 | molecular_function | palmitoyltransferase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| B | 0042759 | biological_process | long-chain fatty acid biosynthetic process |
| B | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue NAP A 1901 |
| Chain | Residue |
| A | GLY684 |
| A | PHE773 |
| A | ALA774 |
| A | ALA775 |
| A | ILE796 |
| A | PRO824 |
| A | TYR838 |
| A | LYS842 |
| A | GLY869 |
| A | THR871 |
| A | GLY875 |
| A | GLY686 |
| A | LEU876 |
| A | MET877 |
| A | SER689 |
| A | ILE690 |
| A | THR709 |
| A | SER710 |
| A | ARG711 |
| A | ASN740 |
| A | GLN741 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue FMN B 2101 |
| Chain | Residue |
| B | ALA582 |
| B | GLY583 |
| B | MET584 |
| B | THR585 |
| B | ASN637 |
| B | LYS693 |
| B | THR720 |
| B | ARG723 |
| B | GLY724 |
| B | GLY725 |
| B | GLY755 |
| B | SER756 |
| B | GLY757 |
| B | PHE758 |
| B | GLY789 |
| B | SER790 |
| B | MET793 |
| B | LEU1042 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue NAP B 2102 |
| Chain | Residue |
| B | PHE612 |
| B | PHE644 |
| B | GLY726 |
| B | HIS727 |
| B | HIS728 |
| B | GLY999 |
| B | GLN1000 |
| B | LYS1001 |
| B | PRO1002 |
| B | LYS1019 |
| B | ASP1020 |
| B | LEU1022 |
| B | LEU1042 |
Functional Information from PROSITE/UniProt
| site_id | PS00606 |
| Number of Residues | 17 |
| Details | KS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATAveSV |
| Chain | Residue | Details |
| A | GLY1294-VAL1310 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 540 |
| Details | Domain: {"description":"Ketosynthase family 3 (KS3)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 128 |
| Details | Domain: {"description":"MaoC-like"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 333 |
| Details | Region: {"description":"Enoyl reductase","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 480 |
| Details | Region: {"description":"Dehydratase","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 220 |
| Details | Region: {"description":"Malonyl/palmitoyl transferase","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For acetyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For malonyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
