6U5W

Electron cryomicroscopy structure of C. albicans FAS in the KS-stalled state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004312	molecular_function	fatty acid synthase activity
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A	0004321	molecular_function	fatty-acyl-CoA synthase activity
A	0005835	cellular_component	fatty acid synthase complex
A	0006633	biological_process	fatty acid biosynthetic process
A	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0101026	biological_process	mitotic nuclear membrane biogenesis
A	1900535	biological_process	palmitic acid biosynthetic process
B	0004312	molecular_function	fatty acid synthase activity
B	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
B	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
B	0004317	molecular_function	(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
B	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B	0004319	molecular_function	obsolete enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
B	0004321	molecular_function	fatty-acyl-CoA synthase activity
B	0005811	cellular_component	lipid droplet
B	0005829	cellular_component	cytosol
B	0005835	cellular_component	fatty acid synthase complex
B	0006633	biological_process	fatty acid biosynthetic process
B	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
B	0016409	molecular_function	palmitoyltransferase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0016787	molecular_function	hydrolase activity
B	0016829	molecular_function	lyase activity
B	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
B	0042759	biological_process	long-chain fatty acid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue NAP A 1901

Chain	Residue
A	GLY684
A	PHE773
A	ALA774
A	ALA775
A	ILE796
A	PRO824
A	TYR838
A	LYS842
A	GLY869
A	THR871
A	GLY875
A	GLY686
A	LEU876
A	MET877
A	SER689
A	ILE690
A	THR709
A	SER710
A	ARG711
A	ASN740
A	GLN741

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site_id	AC2
Number of Residues	18
Details	binding site for residue FMN B 2101

Chain	Residue
B	ALA582
B	GLY583
B	MET584
B	THR585
B	ASN637
B	LYS693
B	THR720
B	ARG723
B	GLY724
B	GLY725
B	GLY755
B	SER756
B	GLY757
B	PHE758
B	GLY789
B	SER790
B	MET793
B	LEU1042

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site_id	AC3
Number of Residues	13
Details	binding site for residue NAP B 2102

Chain	Residue
B	PHE612
B	PHE644
B	GLY726
B	HIS727
B	HIS728
B	GLY999
B	GLN1000
B	LYS1001
B	PRO1002
B	LYS1019
B	ASP1020
B	LEU1022
B	LEU1042

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Functional Information from PROSITE/UniProt

site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATAveSV

Chain	Residue	Details
A	GLY1294-VAL1310

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: For acetyltransferase activity => ECO:0000250

Chain	Residue	Details
B	SER261
A	PRO1708
A	VAL1749

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: For malonyltransferase activity => ECO:0000250

Chain	Residue	Details
B	SER1796

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: O-(pantetheine 4'-phosphoryl)serine => ECO:0000255|PROSITE-ProRule:PRU00258

Chain	Residue	Details
A	LEU344

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