6U5V

Electron cryomicroscopy Structure of C. albicans FAS in the Apo state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004312	molecular_function	fatty acid synthase activity
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A	0004321	molecular_function	fatty-acyl-CoA synthase activity
A	0005835	cellular_component	fatty acid synthase complex
A	0006633	biological_process	fatty acid biosynthetic process
A	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0101026	biological_process	mitotic nuclear membrane biogenesis
A	1900535	biological_process	palmitic acid biosynthetic process
B	0004312	molecular_function	fatty acid synthase activity
B	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
B	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
B	0004317	molecular_function	(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
B	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B	0004319	molecular_function	obsolete enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
B	0004321	molecular_function	fatty-acyl-CoA synthase activity
B	0005811	cellular_component	lipid droplet
B	0005829	cellular_component	cytosol
B	0005835	cellular_component	fatty acid synthase complex
B	0006633	biological_process	fatty acid biosynthetic process
B	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
B	0016409	molecular_function	palmitoyltransferase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0016787	molecular_function	hydrolase activity
B	0016829	molecular_function	lyase activity
B	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
B	0042759	biological_process	long-chain fatty acid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue PNS A 1901

Chain	Residue
A	SER181
B	ALA670
B	HIS727

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site_id	AC2
Number of Residues	20
Details	binding site for residue FMN B 2101

Chain	Residue
B	GLY669
B	LYS693
B	THR720
B	ARG723
B	GLY724
B	GLY725
B	SER756
B	GLY757
B	PHE758
B	GLY789
B	SER790
B	MET793
B	LEU1042
B	ALA1047
B	ALA582
B	GLY583
B	MET584
B	THR585
B	PRO586
B	THR587

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Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. LVNGKSTVQNEILGDL

Chain	Residue	Details
A	LEU176-LEU191

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site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATAveSV

Chain	Residue	Details
A	GLY1295-VAL1311

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: For acetyltransferase activity => ECO:0000250

Chain	Residue	Details
B	SER261
A	HIS1546
A	HIS1587

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: For malonyltransferase activity => ECO:0000250

Chain	Residue	Details
B	SER1796
A	HIS1872
A	VAL1772
A	GLU1773
A	TYR1797
A	SER1807
A	GLU1816
A	ARG1840
A	ILE1870
A	SER1871

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: O-(pantetheine 4'-phosphoryl)serine => ECO:0000255|PROSITE-ProRule:PRU00258

Chain	Residue	Details
A	SER181

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