6U5V
Electron cryomicroscopy Structure of C. albicans FAS in the Apo state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004312 | molecular_function | fatty acid synthase activity |
| A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| A | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| A | 0004321 | molecular_function | fatty-acyl-CoA synthase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005835 | cellular_component | fatty acid synthase complex |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0008897 | molecular_function | holo-[acyl-carrier-protein] synthase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0042759 | biological_process | long-chain fatty acid biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0101026 | biological_process | mitotic nuclear membrane biogenesis |
| A | 1900535 | biological_process | palmitic acid biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004312 | molecular_function | fatty acid synthase activity |
| B | 0004313 | molecular_function | [acyl-carrier-protein] S-acetyltransferase activity |
| B | 0004314 | molecular_function | [acyl-carrier-protein] S-malonyltransferase activity |
| B | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| B | 0004321 | molecular_function | fatty-acyl-CoA synthase activity |
| B | 0005811 | cellular_component | lipid droplet |
| B | 0005829 | cellular_component | cytosol |
| B | 0005835 | cellular_component | fatty acid synthase complex |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016297 | molecular_function | fatty acyl-[ACP] hydrolase activity |
| B | 0016409 | molecular_function | palmitoyltransferase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| B | 0042759 | biological_process | long-chain fatty acid biosynthetic process |
| B | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue PNS A 1901 |
| Chain | Residue |
| A | SER181 |
| B | ALA670 |
| B | HIS727 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | binding site for residue FMN B 2101 |
| Chain | Residue |
| B | GLY669 |
| B | LYS693 |
| B | THR720 |
| B | ARG723 |
| B | GLY724 |
| B | GLY725 |
| B | SER756 |
| B | GLY757 |
| B | PHE758 |
| B | GLY789 |
| B | SER790 |
| B | MET793 |
| B | LEU1042 |
| B | ALA1047 |
| B | ALA582 |
| B | GLY583 |
| B | MET584 |
| B | THR585 |
| B | PRO586 |
| B | THR587 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 75 |
| Details | Domain: {"description":"Carrier","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 540 |
| Details | Domain: {"description":"Ketosynthase family 3 (KS3)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Active site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 128 |
| Details | Domain: {"description":"MaoC-like"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 333 |
| Details | Region: {"description":"Enoyl reductase","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 480 |
| Details | Region: {"description":"Dehydratase","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 220 |
| Details | Region: {"description":"Malonyl/palmitoyl transferase","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For acetyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For malonyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
