6U4X

Crystal structure of Equine Serum Albumin complex with ibuprofen

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0005504	molecular_function	fatty acid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0008289	molecular_function	lipid binding
A	0009267	biological_process	cellular response to starvation
A	0015643	molecular_function	toxic substance binding
A	0019825	molecular_function	oxygen binding
A	0030170	molecular_function	pyridoxal phosphate binding
A	0031667	biological_process	response to nutrient levels
A	0032991	cellular_component	protein-containing complex
A	0046872	molecular_function	metal ion binding
A	0051902	biological_process	negative regulation of mitochondrial depolarization
A	0072732	biological_process	cellular response to calcium ion starvation
A	1903981	molecular_function	enterobactin binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue IBP A 611

Chain	Residue
A	ARG409
A	TYR410
A	LYS413
A	LEU452
A	LEU459
A	PHE487
A	HOH780

---

site_id	AC2
Number of Residues	6
Details	binding site for residue IBP A 612

Chain	Residue
A	GLY21
A	LEU24
A	ASP131
A	LEU154
A	LYS17
A	LYS20

---

site_id	AC3
Number of Residues	7
Details	binding site for residue SO4 A 613

Chain	Residue
A	SER341
A	SER343
A	ARG347
A	PRO383
A	GLU449
A	ARG484
A	HOH770

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 614

Chain	Residue
A	ALA303
A	LEU304
A	ALA305
A	ARG336

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 A 615

Chain	Residue
A	LYS412
A	THR539
A	LYS540
A	HOH704
A	HOH722

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 A 616

Chain	Residue
A	HIS9
A	ASN12
A	ASP13
A	GLU57

---

site_id	AC7
Number of Residues	5
Details	binding site for residue SO4 A 617

Chain	Residue
A	LYS224
A	PRO298
A	SER299
A	GLU569
A	GLU570

---

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 A 618

Chain	Residue
A	SER65
A	HIS67
A	HOH701

---

site_id	AC9
Number of Residues	3
Details	binding site for residue SO4 A 619

Chain	Residue
A	LYS180
A	ALA183
A	ARG187

---

site_id	AD1
Number of Residues	2
Details	binding site for residue SO4 A 620

Chain	Residue
A	PRO516
A	GLU517

---

site_id	AD2
Number of Residues	4
Details	binding site for residue SO4 A 621

Chain	Residue
A	GLY206
A	GLU207
A	HOH710
A	HOH739

---

site_id	AD3
Number of Residues	4
Details	binding site for residue SO4 A 622

Chain	Residue
A	ASN111
A	GLU265
A	HIS266
A	SER269

---

Functional Information from PROSITE/UniProt

site_id	PS00212
Number of Residues	25
Details	ALBUMIN_1 Albumin domain signature. YkadfteCCpaDdklaCLipkldaL

Chain	Residue	Details
A	TYR160-LEU184
A	TYR352-PHE376
A	PHE550-LEU574

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	192
Details	Domain: {"description":"Albumin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00769","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	197
Details	Domain: {"description":"Albumin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00769","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P02769","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28567254","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IIH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P02768","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P02768","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P02768","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P02770","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P07724","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---