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6U2P

PCSK9 in complex with compound 5

Functional Information from GO Data
ChainGOidnamespacecontents
A0001822biological_processkidney development
A0001889biological_processliver development
A0001920biological_processnegative regulation of receptor recycling
A0002091biological_processnegative regulation of receptor internalization
A0002092biological_processpositive regulation of receptor internalization
A0003723molecular_functionRNA binding
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005783cellular_componentendoplasmic reticulum
A0005788cellular_componentendoplasmic reticulum lumen
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0006641biological_processtriglyceride metabolic process
A0006644biological_processphospholipid metabolic process
A0006915biological_processapoptotic process
A0007041biological_processlysosomal transport
A0008203biological_processcholesterol metabolic process
A0008236molecular_functionserine-type peptidase activity
A0009267biological_processcellular response to starvation
A0009986cellular_componentcell surface
A0010469biological_processregulation of signaling receptor activity
A0010989biological_processnegative regulation of low-density lipoprotein particle clearance
A0016485biological_processprotein processing
A0016540biological_processprotein autoprocessing
A0019871molecular_functionsodium channel inhibitor activity
A0022008biological_processneurogenesis
A0030134cellular_componentCOPII-coated ER to Golgi transport vesicle
A0030169molecular_functionlow-density lipoprotein particle binding
A0030182biological_processneuron differentiation
A0030547molecular_functionsignaling receptor inhibitor activity
A0031232cellular_componentextrinsic component of external side of plasma membrane
A0032799biological_processlow-density lipoprotein receptor particle metabolic process
A0032802biological_processlow-density lipoprotein particle receptor catabolic process
A0032803biological_processregulation of low-density lipoprotein particle receptor catabolic process
A0032805biological_processpositive regulation of low-density lipoprotein particle receptor catabolic process
A0032869biological_processcellular response to insulin stimulus
A0034185molecular_functionapolipoprotein binding
A0034189molecular_functionvery-low-density lipoprotein particle binding
A0034190molecular_functionapolipoprotein receptor binding
A0036020cellular_componentendolysosome membrane
A0042157biological_processlipoprotein metabolic process
A0042632biological_processcholesterol homeostasis
A0043523biological_processregulation of neuron apoptotic process
A0043525biological_processpositive regulation of neuron apoptotic process
A0048471cellular_componentperinuclear region of cytoplasm
A0050750molecular_functionlow-density lipoprotein particle receptor binding
A0070326molecular_functionvery-low-density lipoprotein particle receptor binding
A1905596biological_processnegative regulation of low-density lipoprotein particle receptor binding
A1905598biological_processnegative regulation of low-density lipoprotein receptor activity
A1905601biological_processnegative regulation of receptor-mediated endocytosis involved in cholesterol transport
A1990666cellular_componentPCSK9-LDLR complex
A1990667cellular_componentPCSK9-AnxA2 complex
A2000650biological_processnegative regulation of sodium ion transmembrane transporter activity
B0001822biological_processkidney development
B0001889biological_processliver development
B0001920biological_processnegative regulation of receptor recycling
B0002091biological_processnegative regulation of receptor internalization
B0002092biological_processpositive regulation of receptor internalization
B0003723molecular_functionRNA binding
B0004252molecular_functionserine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0005770cellular_componentlate endosome
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0006641biological_processtriglyceride metabolic process
B0006644biological_processphospholipid metabolic process
B0006915biological_processapoptotic process
B0007041biological_processlysosomal transport
B0008203biological_processcholesterol metabolic process
B0008236molecular_functionserine-type peptidase activity
B0009267biological_processcellular response to starvation
B0009986cellular_componentcell surface
B0010469biological_processregulation of signaling receptor activity
B0010989biological_processnegative regulation of low-density lipoprotein particle clearance
B0016485biological_processprotein processing
B0016540biological_processprotein autoprocessing
B0019871molecular_functionsodium channel inhibitor activity
B0022008biological_processneurogenesis
B0030134cellular_componentCOPII-coated ER to Golgi transport vesicle
B0030169molecular_functionlow-density lipoprotein particle binding
B0030182biological_processneuron differentiation
B0030547molecular_functionsignaling receptor inhibitor activity
B0031232cellular_componentextrinsic component of external side of plasma membrane
B0032799biological_processlow-density lipoprotein receptor particle metabolic process
B0032802biological_processlow-density lipoprotein particle receptor catabolic process
B0032803biological_processregulation of low-density lipoprotein particle receptor catabolic process
B0032805biological_processpositive regulation of low-density lipoprotein particle receptor catabolic process
B0032869biological_processcellular response to insulin stimulus
B0034185molecular_functionapolipoprotein binding
B0034189molecular_functionvery-low-density lipoprotein particle binding
B0034190molecular_functionapolipoprotein receptor binding
B0036020cellular_componentendolysosome membrane
B0042157biological_processlipoprotein metabolic process
B0042632biological_processcholesterol homeostasis
B0043523biological_processregulation of neuron apoptotic process
B0043525biological_processpositive regulation of neuron apoptotic process
B0048471cellular_componentperinuclear region of cytoplasm
B0050750molecular_functionlow-density lipoprotein particle receptor binding
B0070326molecular_functionvery-low-density lipoprotein particle receptor binding
B1905596biological_processnegative regulation of low-density lipoprotein particle receptor binding
B1905598biological_processnegative regulation of low-density lipoprotein receptor activity
B1905601biological_processnegative regulation of receptor-mediated endocytosis involved in cholesterol transport
B1990666cellular_componentPCSK9-LDLR complex
B1990667cellular_componentPCSK9-AnxA2 complex
B2000650biological_processnegative regulation of sodium ion transmembrane transporter activity
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue EDO A 801
ChainResidue
AARG66
BHOH990
ACYS67
AALA68
AASP70
AARG73
AHOH914
BGLN275
BALA307
BGLY308

site_idAC2
Number of Residues5
Detailsbinding site for residue EDO A 802
ChainResidue
AHIS116
AGLY117
ALEU119
APRO120
AHOH926

site_idAC3
Number of Residues6
Detailsbinding site for residue EDO B 801
ChainResidue
ATHR63
APHE64
BLEU179
BVAL280
BHOH921
BHOH930

site_idAC4
Number of Residues6
Detailsbinding site for residue EDO B 802
ChainResidue
BGLU159
BTYR166
BLYS609
BCYS626
BGLU627
BTRP630

site_idAC5
Number of Residues6
Detailsbinding site for residue EDO B 803
ChainResidue
BSER485
BSER487
BILE523
BCYS635
BTYR648
BALA649

site_idAC6
Number of Residues19
Detailsbinding site for residue PUV B 804
ChainResidue
BALA328
BSER329
BALA330
BPRO331
BVAL333
BTHR335
BARG357
BCYS358
BASP360
BARG412
BARG458
BVAL460
BTRP461
BILE474
BALA475
BARG476
BALA478
BHOH929
BHOH984

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240
ChainResidueDetails
AASP186
AHIS226
ASER386
BASP186
BHIS226
BSER386

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Cleavage; by autolysis => ECO:0000269|PubMed:14622975
ChainResidueDetails
AGLN152
BGLN152

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Cleavage; by furin and PCSK5 => ECO:0000269|PubMed:16912035
ChainResidueDetails
AARG218
BARG218

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Sulfotyrosine => ECO:0000269|PubMed:16912035
ChainResidueDetails
ATYR38
BTYR38

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:18498363, ECO:0000269|PubMed:26091039
ChainResidueDetails
ASER47
BSER47

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:18498363, ECO:0000269|PubMed:26091039, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER688
BSER688

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16912035
ChainResidueDetails
AASN533
BASN533

221051

PDB entries from 2024-06-12

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