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6U26

PCSK9 in complex with compound 16

Functional Information from GO Data
ChainGOidnamespacecontents
A0001822biological_processkidney development
A0001889biological_processliver development
A0001920biological_processnegative regulation of receptor recycling
A0002091biological_processnegative regulation of receptor internalization
A0002092biological_processpositive regulation of receptor internalization
A0003723molecular_functionRNA binding
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005783cellular_componentendoplasmic reticulum
A0005788cellular_componentendoplasmic reticulum lumen
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0006641biological_processtriglyceride metabolic process
A0006644biological_processphospholipid metabolic process
A0006915biological_processapoptotic process
A0007041biological_processlysosomal transport
A0008203biological_processcholesterol metabolic process
A0008236molecular_functionserine-type peptidase activity
A0009267biological_processcellular response to starvation
A0009986cellular_componentcell surface
A0010469biological_processregulation of signaling receptor activity
A0010989biological_processnegative regulation of low-density lipoprotein particle clearance
A0016485biological_processprotein processing
A0016540biological_processprotein autoprocessing
A0019871molecular_functionsodium channel inhibitor activity
A0022008biological_processneurogenesis
A0030134cellular_componentCOPII-coated ER to Golgi transport vesicle
A0030169molecular_functionlow-density lipoprotein particle binding
A0030182biological_processneuron differentiation
A0030547molecular_functionsignaling receptor inhibitor activity
A0031232cellular_componentextrinsic component of external side of plasma membrane
A0032799biological_processlow-density lipoprotein receptor particle metabolic process
A0032802biological_processlow-density lipoprotein particle receptor catabolic process
A0032803biological_processregulation of low-density lipoprotein particle receptor catabolic process
A0032805biological_processpositive regulation of low-density lipoprotein particle receptor catabolic process
A0032869biological_processcellular response to insulin stimulus
A0034185molecular_functionapolipoprotein binding
A0034189molecular_functionvery-low-density lipoprotein particle binding
A0034190molecular_functionapolipoprotein receptor binding
A0036020cellular_componentendolysosome membrane
A0042157biological_processlipoprotein metabolic process
A0042632biological_processcholesterol homeostasis
A0043523biological_processregulation of neuron apoptotic process
A0043525biological_processpositive regulation of neuron apoptotic process
A0048471cellular_componentperinuclear region of cytoplasm
A0050750molecular_functionlow-density lipoprotein particle receptor binding
A0070326molecular_functionvery-low-density lipoprotein particle receptor binding
A1905596biological_processnegative regulation of low-density lipoprotein particle receptor binding
A1905598biological_processnegative regulation of low-density lipoprotein receptor activity
A1905601biological_processnegative regulation of receptor-mediated endocytosis involved in cholesterol transport
A1990666cellular_componentPCSK9-LDLR complex
A1990667cellular_componentPCSK9-AnxA2 complex
A2000650biological_processnegative regulation of sodium ion transmembrane transporter activity
B0001822biological_processkidney development
B0001889biological_processliver development
B0001920biological_processnegative regulation of receptor recycling
B0002091biological_processnegative regulation of receptor internalization
B0002092biological_processpositive regulation of receptor internalization
B0003723molecular_functionRNA binding
B0004252molecular_functionserine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0005770cellular_componentlate endosome
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0006641biological_processtriglyceride metabolic process
B0006644biological_processphospholipid metabolic process
B0006915biological_processapoptotic process
B0007041biological_processlysosomal transport
B0008203biological_processcholesterol metabolic process
B0008236molecular_functionserine-type peptidase activity
B0009267biological_processcellular response to starvation
B0009986cellular_componentcell surface
B0010469biological_processregulation of signaling receptor activity
B0010989biological_processnegative regulation of low-density lipoprotein particle clearance
B0016485biological_processprotein processing
B0016540biological_processprotein autoprocessing
B0019871molecular_functionsodium channel inhibitor activity
B0022008biological_processneurogenesis
B0030134cellular_componentCOPII-coated ER to Golgi transport vesicle
B0030169molecular_functionlow-density lipoprotein particle binding
B0030182biological_processneuron differentiation
B0030547molecular_functionsignaling receptor inhibitor activity
B0031232cellular_componentextrinsic component of external side of plasma membrane
B0032799biological_processlow-density lipoprotein receptor particle metabolic process
B0032802biological_processlow-density lipoprotein particle receptor catabolic process
B0032803biological_processregulation of low-density lipoprotein particle receptor catabolic process
B0032805biological_processpositive regulation of low-density lipoprotein particle receptor catabolic process
B0032869biological_processcellular response to insulin stimulus
B0034185molecular_functionapolipoprotein binding
B0034189molecular_functionvery-low-density lipoprotein particle binding
B0034190molecular_functionapolipoprotein receptor binding
B0036020cellular_componentendolysosome membrane
B0042157biological_processlipoprotein metabolic process
B0042632biological_processcholesterol homeostasis
B0043523biological_processregulation of neuron apoptotic process
B0043525biological_processpositive regulation of neuron apoptotic process
B0048471cellular_componentperinuclear region of cytoplasm
B0050750molecular_functionlow-density lipoprotein particle receptor binding
B0070326molecular_functionvery-low-density lipoprotein particle receptor binding
B1905596biological_processnegative regulation of low-density lipoprotein particle receptor binding
B1905598biological_processnegative regulation of low-density lipoprotein receptor activity
B1905601biological_processnegative regulation of receptor-mediated endocytosis involved in cholesterol transport
B1990666cellular_componentPCSK9-LDLR complex
B1990667cellular_componentPCSK9-AnxA2 complex
B2000650biological_processnegative regulation of sodium ion transmembrane transporter activity
Functional Information from PDB Data
site_idAC1
Number of Residues28
Detailsbinding site for residue 063 B 801
ChainResidue
BARG248
BPRO331
BVAL333
BTHR335
BARG357
BCYS358
BASP360
BARG412
BARG458
BVAL460
BTRP461
BSER274
BALA463
BILE474
BALA475
BARG476
BCYS477
BALA478
BLYS506
BHOH982
BHOH1028
BVAL277
BGLN278
BTYR293
BCYS323
BALA328
BSER329
BALA330

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240
ChainResidueDetails
AASP186
AHIS226
ASER386
BASP186
BHIS226
BSER386

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Cleavage; by autolysis => ECO:0000269|PubMed:14622975
ChainResidueDetails
AGLN152
BGLN152

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Cleavage; by furin and PCSK5 => ECO:0000269|PubMed:16912035
ChainResidueDetails
AARG218
BARG218

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Sulfotyrosine => ECO:0000269|PubMed:16912035
ChainResidueDetails
ATYR38
BTYR38

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:18498363, ECO:0000269|PubMed:26091039
ChainResidueDetails
ASER47
BSER47

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:18498363, ECO:0000269|PubMed:26091039, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER688
BSER688

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16912035
ChainResidueDetails
AASN533
BASN533

222624

PDB entries from 2024-07-17

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