6U25

CRYSTAL STRUCTURE OF RAR-RELATED ORPHAN RECEPTOR C (NHIS- RORGT(244-487)-L6-SRC1(678-692)) IN COMPLEX WITH A TRICYCLIC INVERSE AGONIST

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue O5B A 601

Chain	Residue
A	GLN286
A	PHE388
A	LEU391
A	LEU396
A	ILE397
A	ILE400
A	PHE401
A	HIS479
A	TYR502
A	GOL602
A	HOH703
A	LEU287
A	CYS320
A	LEU324
A	ARG364
A	MET365
A	ARG367
A	PHE377
A	PHE378

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site_id	AC2
Number of Residues	5
Details	binding site for residue GOL A 602

Chain	Residue
A	HIS323
A	PHE377
A	PHE378
A	GLU379
A	O5B601

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