6U1X
Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor (3.0 A resolution)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001172 | biological_process | RNA-templated transcription |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| A | 0006397 | biological_process | mRNA processing |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019083 | biological_process | viral transcription |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0032259 | biological_process | methylation |
| A | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| A | 0039689 | biological_process | negative stranded viral RNA replication |
| A | 0044423 | cellular_component | virion component |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0106005 | biological_process | RNA 5'-cap (guanine-N7)-methylation |
| P | 0001172 | biological_process | RNA-templated transcription |
| P | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| P | 0005515 | molecular_function | protein binding |
| P | 0016310 | biological_process | phosphorylation |
| P | 0019079 | biological_process | viral genome replication |
| P | 0019083 | biological_process | viral transcription |
| P | 0030430 | cellular_component | host cell cytoplasm |
| P | 0034337 | biological_process | RNA folding |
| P | 0044423 | cellular_component | virion component |
| P | 0140691 | molecular_function | RNA folding chaperone |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 3000 |
| Chain | Residue |
| A | CYS1081 |
| A | GLU1108 |
| A | CYS1299 |
| A | CYS1302 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 3001 |
| Chain | Residue |
| A | CYS1120 |
| A | CYS1123 |
| A | HIS1294 |
| A | HIS1296 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Involved in oligomerization => ECO:0000250|UniProtKB:P04880 |
| Chain | Residue | Details |
| P | TRP138 | |
| P | THR141 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by host => ECO:0000269|PubMed:24257610 |
| Chain | Residue | Details |
| P | TYR14 | |
| A | ASP1762 | |
| A | LYS1795 | |
| A | GLU1833 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by host CK2 => ECO:0000269|PubMed:8525614 |
| Chain | Residue | Details |
| P | SER60 | |
| P | SER64 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by host CK2 => ECO:0000269|PubMed:8525614 |
| Chain | Residue | Details |
| P | THR62 | |
| A | GLU1108 | |
| A | CYS1299 | |
| A | CYS1302 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P04880 |
| Chain | Residue | Details |
| P | SER226 | |
| P | SER227 | |
| A | HIS1294 | |
| A | HIS1296 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P04880 |
| Chain | Residue | Details |
| P | SER233 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 9 |
| Details | SITE: Interaction with the phosphoprotein => ECO:0000269|PubMed:31914397 |
| Chain | Residue | Details |
| A | ASN704 | |
| A | ARG1419 | |
| A | ARG1427 | |
| A | GLU1496 | |
| A | GLY1911 | |
| A | ASP1981 | |
| A | LYS2022 | |
| A | LEU2097 | |
| A | LYS2098 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | SITE: Important for escaping from the 3'-terminal leader promotter followed by the formation of a stable leaderRNA elongation complex => ECO:0000269|PubMed:35108335 |
| Chain | Residue | Details |
| A | ARG1183 |
