Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6U0M

Structure of the S. cerevisiae replicative helicase CMG in complex with a forked DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0003677	molecular_function	DNA binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0006260	biological_process	DNA replication
2	0006270	biological_process	DNA replication initiation
2	0042555	cellular_component	MCM complex
3	0003677	molecular_function	DNA binding
3	0005524	molecular_function	ATP binding
3	0006260	biological_process	DNA replication
3	0006270	biological_process	DNA replication initiation
3	0042555	cellular_component	MCM complex
4	0003677	molecular_function	DNA binding
4	0003678	molecular_function	DNA helicase activity
4	0005524	molecular_function	ATP binding
4	0006260	biological_process	DNA replication
4	0006270	biological_process	DNA replication initiation
4	0042555	cellular_component	MCM complex
5	0003677	molecular_function	DNA binding
5	0003688	molecular_function	DNA replication origin binding
5	0005524	molecular_function	ATP binding
5	0005634	cellular_component	nucleus
5	0006260	biological_process	DNA replication
5	0006270	biological_process	DNA replication initiation
5	0042555	cellular_component	MCM complex
6	0003677	molecular_function	DNA binding
6	0003678	molecular_function	DNA helicase activity
6	0005524	molecular_function	ATP binding
6	0005634	cellular_component	nucleus
6	0006260	biological_process	DNA replication
6	0006270	biological_process	DNA replication initiation
6	0042555	cellular_component	MCM complex
7	0003677	molecular_function	DNA binding
7	0003678	molecular_function	DNA helicase activity
7	0005524	molecular_function	ATP binding
7	0006260	biological_process	DNA replication
7	0006270	biological_process	DNA replication initiation
7	0042555	cellular_component	MCM complex
A	0000727	biological_process	double-strand break repair via break-induced replication
A	0000811	cellular_component	GINS complex
A	0003674	molecular_function	molecular_function
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0031261	cellular_component	DNA replication preinitiation complex
A	0043596	cellular_component	nuclear replication fork
A	0071162	cellular_component	CMG complex
A	1902983	biological_process	DNA strand elongation involved in mitotic DNA replication
B	0000228	cellular_component	nuclear chromosome
B	0000727	biological_process	double-strand break repair via break-induced replication
B	0000811	cellular_component	GINS complex
B	0003674	molecular_function	molecular_function
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0031261	cellular_component	DNA replication preinitiation complex
B	0043596	cellular_component	nuclear replication fork
B	0071162	cellular_component	CMG complex
C	0000727	biological_process	double-strand break repair via break-induced replication
C	0000811	cellular_component	GINS complex
C	0003674	molecular_function	molecular_function
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0006260	biological_process	DNA replication
C	0006261	biological_process	DNA-templated DNA replication
C	0006270	biological_process	DNA replication initiation
C	0031261	cellular_component	DNA replication preinitiation complex
C	0043596	cellular_component	nuclear replication fork
C	0071162	cellular_component	CMG complex
D	0000727	biological_process	double-strand break repair via break-induced replication
D	0000811	cellular_component	GINS complex
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0031261	cellular_component	DNA replication preinitiation complex
D	0043596	cellular_component	nuclear replication fork
D	0071162	cellular_component	CMG complex
E	0000727	biological_process	double-strand break repair via break-induced replication
E	0003682	molecular_function	chromatin binding
E	0003688	molecular_function	DNA replication origin binding
E	0003697	molecular_function	single-stranded DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0006260	biological_process	DNA replication
E	0006270	biological_process	DNA replication initiation
E	0031261	cellular_component	DNA replication preinitiation complex
E	0043596	cellular_component	nuclear replication fork
E	0071162	cellular_component	CMG complex
E	1902977	biological_process	mitotic DNA replication preinitiation complex assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue ATP 2 901

Chain	Residue
2	ILE505
2	VAL699
6	LEU565
6	GLU657
6	ARG708
6	GLU801
2	TYR506
2	PRO545
2	GLY546
2	THR547
2	ALA548
2	LYS549
2	SER550
2	LEU695

site_id	AC2
Number of Residues	14
Details	binding site for residue ATP 3 1001

Chain	Residue
3	ILE371
3	PRO411
3	SER412
3	THR413
3	ALA414
3	LYS415
3	SER416
3	GLN417
3	ASN517
5	LEU406
5	GLU498
5	ARG549
5	ILE650
5	ARG651

site_id	AC3
Number of Residues	17
Details	binding site for residue ATP 5 801

Chain	Residue
2	HIS531
2	GLU625
2	ARG676
2	VAL807
2	ARG808
2	GLU811
5	SER377
5	ILE378
5	PHE379
5	ASP417
5	PRO418
5	GLY419
5	THR420
5	ALA421
5	LYS422
5	SER423
5	GLN424

Functional Information from PROSITE/UniProt

site_id	PS00847
Number of Residues	9
Details	MCM_1 MCM family signature. GICCIDEFD

Chain	Residue	Details
7	GLY519-ASP527
2	GLY602-ASP610
3	GLY468-ASP476
4	GLY627-ASP635
5	GLY475-ASP483
6	GLY634-ASP642

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1035
Details	Domain: {"description":"MCM"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	26
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	15
Details	Motif: {"description":"Arginine finger"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	35
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P33993","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)