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6TWZ

14-3-3 sigma complexed with a phosphorylated 16E6 peptide

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001836biological_processrelease of cytochrome c from mitochondria
A0003334biological_processkeratinocyte development
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006469biological_processnegative regulation of protein kinase activity
A0006611biological_processprotein export from nucleus
A0007165biological_processsignal transduction
A0008426molecular_functionprotein kinase C inhibitor activity
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0010482biological_processregulation of epidermal cell division
A0010737biological_processprotein kinase A signaling
A0010839biological_processnegative regulation of keratinocyte proliferation
A0019901molecular_functionprotein kinase binding
A0030216biological_processkeratinocyte differentiation
A0030307biological_processpositive regulation of cell growth
A0031424biological_processkeratinization
A0042802molecular_functionidentical protein binding
A0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A0043588biological_processskin development
A0043616biological_processkeratinocyte proliferation
A0045296molecular_functioncadherin binding
A0045606biological_processpositive regulation of epidermal cell differentiation
A0045824biological_processnegative regulation of innate immune response
A0046827biological_processpositive regulation of protein export from nucleus
A0050815molecular_functionphosphoserine residue binding
A0051219molecular_functionphosphoprotein binding
A0051726biological_processregulation of cell cycle
A0061436biological_processestablishment of skin barrier
A0070062cellular_componentextracellular exosome
A0072089biological_processstem cell proliferation
A0140311molecular_functionprotein sequestering activity
A2000647biological_processnegative regulation of stem cell proliferation
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001836biological_processrelease of cytochrome c from mitochondria
B0003334biological_processkeratinocyte development
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006469biological_processnegative regulation of protein kinase activity
B0006611biological_processprotein export from nucleus
B0007165biological_processsignal transduction
B0008426molecular_functionprotein kinase C inhibitor activity
B0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
B0010482biological_processregulation of epidermal cell division
B0010737biological_processprotein kinase A signaling
B0010839biological_processnegative regulation of keratinocyte proliferation
B0019901molecular_functionprotein kinase binding
B0030216biological_processkeratinocyte differentiation
B0030307biological_processpositive regulation of cell growth
B0031424biological_processkeratinization
B0042802molecular_functionidentical protein binding
B0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
B0043588biological_processskin development
B0043616biological_processkeratinocyte proliferation
B0045296molecular_functioncadherin binding
B0045606biological_processpositive regulation of epidermal cell differentiation
B0045824biological_processnegative regulation of innate immune response
B0046827biological_processpositive regulation of protein export from nucleus
B0050815molecular_functionphosphoserine residue binding
B0051219molecular_functionphosphoprotein binding
B0051726biological_processregulation of cell cycle
B0061436biological_processestablishment of skin barrier
B0070062cellular_componentextracellular exosome
B0072089biological_processstem cell proliferation
B0140311molecular_functionprotein sequestering activity
B2000647biological_processnegative regulation of stem cell proliferation
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001836biological_processrelease of cytochrome c from mitochondria
C0003334biological_processkeratinocyte development
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006469biological_processnegative regulation of protein kinase activity
C0006611biological_processprotein export from nucleus
C0007165biological_processsignal transduction
C0008426molecular_functionprotein kinase C inhibitor activity
C0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
C0010482biological_processregulation of epidermal cell division
C0010737biological_processprotein kinase A signaling
C0010839biological_processnegative regulation of keratinocyte proliferation
C0019901molecular_functionprotein kinase binding
C0030216biological_processkeratinocyte differentiation
C0030307biological_processpositive regulation of cell growth
C0031424biological_processkeratinization
C0042802molecular_functionidentical protein binding
C0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
C0043588biological_processskin development
C0043616biological_processkeratinocyte proliferation
C0045296molecular_functioncadherin binding
C0045606biological_processpositive regulation of epidermal cell differentiation
C0045824biological_processnegative regulation of innate immune response
C0046827biological_processpositive regulation of protein export from nucleus
C0050815molecular_functionphosphoserine residue binding
C0051219molecular_functionphosphoprotein binding
C0051726biological_processregulation of cell cycle
C0061436biological_processestablishment of skin barrier
C0070062cellular_componentextracellular exosome
C0072089biological_processstem cell proliferation
C0140311molecular_functionprotein sequestering activity
C2000647biological_processnegative regulation of stem cell proliferation
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0001836biological_processrelease of cytochrome c from mitochondria
D0003334biological_processkeratinocyte development
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006469biological_processnegative regulation of protein kinase activity
D0006611biological_processprotein export from nucleus
D0007165biological_processsignal transduction
D0008426molecular_functionprotein kinase C inhibitor activity
D0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
D0010482biological_processregulation of epidermal cell division
D0010737biological_processprotein kinase A signaling
D0010839biological_processnegative regulation of keratinocyte proliferation
D0019901molecular_functionprotein kinase binding
D0030216biological_processkeratinocyte differentiation
D0030307biological_processpositive regulation of cell growth
D0031424biological_processkeratinization
D0042802molecular_functionidentical protein binding
D0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
D0043588biological_processskin development
D0043616biological_processkeratinocyte proliferation
D0045296molecular_functioncadherin binding
D0045606biological_processpositive regulation of epidermal cell differentiation
D0045824biological_processnegative regulation of innate immune response
D0046827biological_processpositive regulation of protein export from nucleus
D0050815molecular_functionphosphoserine residue binding
D0051219molecular_functionphosphoprotein binding
D0051726biological_processregulation of cell cycle
D0061436biological_processestablishment of skin barrier
D0070062cellular_componentextracellular exosome
D0072089biological_processstem cell proliferation
D0140311molecular_functionprotein sequestering activity
D2000647biological_processnegative regulation of stem cell proliferation
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue TAR A 301
ChainResidue
AGLN93
AASP97
ALEU131
AASP139

site_idAC2
Number of Residues4
Detailsbinding site for residue TAR B 301
ChainResidue
BASP97
BLEU131
BASP139
BILE143

site_idAC3
Number of Residues4
Detailsbinding site for residue TAR C 301
ChainResidue
CASP97
CLEU131
CASP139
CGLN93

site_idAC4
Number of Residues2
Detailsbinding site for residue TAR D 301
ChainResidue
DASP97
DLEU131

site_idAC5
Number of Residues6
Detailsbinding site for residue B3P D 302
ChainResidue
DTYR213
DTYR213
DMET220
DMET220
DGLN221
DGLN221

site_idAC6
Number of Residues7
Detailsbinding site for Di-peptide GLU D0 155 and TPO D0 156
ChainResidue
AARG56
AARG129
ATYR130
AASN175
AVAL178
ALEU222
AASN226

site_idAC7
Number of Residues6
Detailsbinding site for Di-peptide TPO D0 156 and GLN D0 157
ChainResidue
AARG56
ALYS122
AARG129
ATYR130
AASN175
ALEU218

site_idAC8
Number of Residues10
Detailsbinding site for Di-peptide GLU E 155 and TPO E 156
ChainResidue
BLYS49
BARG56
BARG129
BTYR130
BASN175
BVAL178
BLEU222
BASN226
EARG154
EGLN157

site_idAC9
Number of Residues10
Detailsbinding site for Di-peptide TPO E 156 and GLN E 157
ChainResidue
BLYS49
BARG56
BLYS122
BARG129
BTYR130
BASN175
BLEU222
EARG154
EGLU155
ELEU158

site_idAD1
Number of Residues9
Detailsbinding site for Di-peptide GLU F 155 and TPO F 156
ChainResidue
CARG56
CARG129
CTYR130
CASN175
CVAL178
CLEU222
CASN226
FARG154
FGLN157

site_idAD2
Number of Residues10
Detailsbinding site for Di-peptide TPO F 156 and GLN F 157
ChainResidue
CARG56
CLYS122
CARG129
CTYR130
CASN175
CVAL178
CLEU218
FARG154
FGLU155
FLEU158

site_idAD3
Number of Residues12
Detailsbinding site for Di-peptide GLU G 155 and TPO G 156
ChainResidue
DLYS49
DARG56
DARG129
DTYR130
DLEU174
DASN175
DVAL178
DLEU222
DASN226
GARG151
GARG154
GGLN157

site_idAD4
Number of Residues11
Detailsbinding site for Di-peptide TPO G 156 and GLN G 157
ChainResidue
DLYS49
DARG56
DLYS122
DARG129
DTYR130
DLEU174
DASN175
DLEU222
GARG154
GGLU155
GLEU158

Functional Information from PROSITE/UniProt
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
AARG41-VAL51

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsSITE: Interaction with phosphoserine on interacting protein
ChainResidueDetails
AARG56
AARG129
BARG56
BARG129
CARG56
CARG129
DARG56
DARG129

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER5
BSER5
CSER5
DSER5

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER74
BSER74
CSER74
DSER74

218853

PDB entries from 2024-04-24

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