6TVN
Crystal Structure of 5-bromoindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue NYQ A 201 |
| Chain | Residue |
| A | LYS12 |
| A | SER14 |
| A | GLN15 |
| A | LEU37 |
| A | TYR39 |
| A | ILE56 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 202 |
| Chain | Residue |
| A | CYS165 |
| A | HIS143 |
| A | CYS154 |
| A | CYS155 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 203 |
| Chain | Residue |
| A | GLU96 |
| B | HOH301 |
| B | HOH302 |
| B | HOH303 |
| B | HOH312 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 202 |
| Chain | Residue |
| B | HIS143 |
| B | CYS154 |
| B | CYS155 |
| B | CYS165 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue NYQ C 201 |
| Chain | Residue |
| C | LYS12 |
| C | SER14 |
| C | GLN15 |
| C | LEU37 |
| C | TYR39 |
| C | ILE56 |
| C | LEU111 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 202 |
| Chain | Residue |
| C | HIS143 |
| C | CYS154 |
| C | CYS155 |
| C | CYS165 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 202 |
| Chain | Residue |
| D | HIS143 |
| D | CYS154 |
| D | CYS155 |
| D | CYS165 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue MG D 203 |
| Chain | Residue |
| C | HOH304 |
| C | HOH305 |
| D | GLU96 |
| D | HOH301 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide NYQ B 201 and LYS B 12 |
| Chain | Residue |
| B | LEU11 |
| B | ARG13 |
| B | SER14 |
| B | GLN15 |
| B | PHE25 |
| B | LYS26 |
| B | LEU37 |
| B | TYR39 |
| B | ILE56 |
| B | LEU111 |
| B | TYR112 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide NYQ D 201 and LYS D 12 |
| Chain | Residue |
| D | LEU11 |
| D | ARG13 |
| D | SER14 |
| D | GLN15 |
| D | PHE25 |
| D | LYS26 |
| D | TYR39 |
| D | LEU111 |
| D | TYR112 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Region: {"description":"Inositol-(1,3,4,5)-tetrakisphosphate 1-binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10196129","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00432","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10196129","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9218782","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2007","submissionDatabase":"PDB data bank","title":"Crystal structure of PH domain of Bruton's tyrosine kinase.","authors":["Murayama K.","Kato-Murayama M.","Mishima C.","Shirouzu M.","Yokoyama S."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Claeys D."]}},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16644721","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P35991","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
