Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6TTZ

Structure of the ClpP:ADEP4-complex from Staphylococcus aureus (open state)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0009368	cellular_component	endopeptidase Clp complex
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0051117	molecular_function	ATPase binding
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0009368	cellular_component	endopeptidase Clp complex
B	0016787	molecular_function	hydrolase activity
B	0042802	molecular_function	identical protein binding
B	0051117	molecular_function	ATPase binding
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0009368	cellular_component	endopeptidase Clp complex
C	0016787	molecular_function	hydrolase activity
C	0042802	molecular_function	identical protein binding
C	0051117	molecular_function	ATPase binding
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0009368	cellular_component	endopeptidase Clp complex
D	0016787	molecular_function	hydrolase activity
D	0042802	molecular_function	identical protein binding
D	0051117	molecular_function	ATPase binding
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0009368	cellular_component	endopeptidase Clp complex
E	0016787	molecular_function	hydrolase activity
E	0042802	molecular_function	identical protein binding
E	0051117	molecular_function	ATPase binding
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0006508	biological_process	proteolysis
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0008233	molecular_function	peptidase activity
F	0008236	molecular_function	serine-type peptidase activity
F	0009368	cellular_component	endopeptidase Clp complex
F	0016787	molecular_function	hydrolase activity
F	0042802	molecular_function	identical protein binding
F	0051117	molecular_function	ATPase binding
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0006508	biological_process	proteolysis
G	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
G	0008233	molecular_function	peptidase activity
G	0008236	molecular_function	serine-type peptidase activity
G	0009368	cellular_component	endopeptidase Clp complex
G	0016787	molecular_function	hydrolase activity
G	0042802	molecular_function	identical protein binding
G	0051117	molecular_function	ATPase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue NWT A 901

Chain	Residue
A	ARG23
A	MET190
G	VAL45
G	LEU49
G	THR80
G	HIS83
A	LEU24
A	ILE29
A	TYR61
A	TYR63
A	GLN89
A	ILE91
A	ILE93
A	LEU115

site_id	AC2
Number of Residues	15
Details	binding site for residue NWT B 901

Chain	Residue
A	VAL45
A	LEU49
A	THR80
A	HIS83
B	ARG23
B	LEU24
B	ASP27
B	ILE29
B	TYR61
B	TYR63
B	GLN89
B	ILE93
B	LEU115
E	ASN12
E	ARG13

site_id	AC3
Number of Residues	13
Details	binding site for residue NWT C 901

Chain	Residue
B	LEU49
B	THR80
B	HIS83
C	ARG23
C	LEU24
C	ASP27
C	ILE29
C	TYR61
C	TYR63
C	GLN89
C	ILE91
C	ILE93
C	LEU115

site_id	AC4
Number of Residues	14
Details	binding site for residue NWT D 901

Chain	Residue
C	VAL45
C	LEU49
C	ALA53
C	THR80
C	HIS83
D	LEU24
D	ASP27
D	ILE29
D	TYR61
D	TYR63
D	GLN89
D	ILE91
D	ILE93
D	HOH1016

site_id	AC5
Number of Residues	15
Details	binding site for residue NWT E 901

Chain	Residue
D	LEU49
D	ALA53
D	THR80
D	HIS83
D	HOH1013
E	ARG23
E	LEU24
E	ASP27
E	ILE29
E	TYR61
E	TYR63
E	GLN89
E	ILE93
E	LEU115
E	GLU193

site_id	AC6
Number of Residues	17
Details	binding site for residue NWT F 901

Chain	Residue
E	VAL45
E	LEU49
E	ALA53
E	THR80
E	HIS83
E	HOH1019
F	ARG23
F	LEU24
F	ASP27
F	ILE29
F	TYR61
F	TYR63
F	GLN89
F	ILE93
F	LEU115
F	MET190
F	GLU193

site_id	AC7
Number of Residues	13
Details	binding site for residue NWT G 901

Chain	Residue
G	LEU115
G	MET190
F	VAL45
F	LEU49
F	THR80
F	HIS83
G	ARG23
G	ASP27
G	ILE29
G	TYR61
G	TYR63
G	GLN89
G	ILE93

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TicIGmAASMGS

Chain	Residue	Details
A	THR90-SER101

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RfalPnaeVMIHQP

Chain	Residue	Details
A	ARG112-PRO125

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	7
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)