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6TTX

Crystal structure of the human METTL3-METTL14 complex bound to Compound 5 (ASI_M3M_051)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000398biological_processmRNA splicing, via spliceosome
A0001510biological_processRNA methylation
A0001734molecular_functionmRNA m(6)A methyltransferase activity
A0003723molecular_functionRNA binding
A0003729molecular_functionmRNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006397biological_processmRNA processing
A0006974biological_processDNA damage response
A0007283biological_processspermatogenesis
A0007623biological_processcircadian rhythm
A0008168molecular_functionmethyltransferase activity
A0008173molecular_functionRNA methyltransferase activity
A0008757molecular_functionS-adenosylmethionine-dependent methyltransferase activity
A0009048biological_processdosage compensation by inactivation of X chromosome
A0016422molecular_functionmRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
A0016556biological_processmRNA modification
A0016604cellular_componentnuclear body
A0016607cellular_componentnuclear speck
A0019827biological_processstem cell population maintenance
A0021861biological_processforebrain radial glial cell differentiation
A0030154biological_processcell differentiation
A0031053biological_processprimary miRNA processing
A0032259biological_processmethylation
A0034644biological_processcellular response to UV
A0036396cellular_componentRNA N6-methyladenosine methyltransferase complex
A0042063biological_processgliogenesis
A0045087biological_processinnate immune response
A0045580biological_processregulation of T cell differentiation
A0045727biological_processpositive regulation of translation
A0045746biological_processnegative regulation of Notch signaling pathway
A0046982molecular_functionprotein heterodimerization activity
A0048477biological_processoogenesis
A0048511biological_processrhythmic process
A0051445biological_processregulation of meiotic cell cycle
A0060255biological_processregulation of macromolecule metabolic process
A0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
A0061157biological_processmRNA destabilization
A0098508biological_processendothelial to hematopoietic transition
A0140640molecular_functioncatalytic activity, acting on a nucleic acid
A1902036biological_processregulation of hematopoietic stem cell differentiation
A1903679biological_processpositive regulation of cap-independent translational initiation
A1904047molecular_functionS-adenosyl-L-methionine binding
B0000398biological_processmRNA splicing, via spliceosome
B0001510biological_processRNA methylation
B0001734molecular_functionmRNA m(6)A methyltransferase activity
B0003723molecular_functionRNA binding
B0003729molecular_functionmRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0006397biological_processmRNA processing
B0006402biological_processmRNA catabolic process
B0007283biological_processspermatogenesis
B0008757molecular_functionS-adenosylmethionine-dependent methyltransferase activity
B0016556biological_processmRNA modification
B0019827biological_processstem cell population maintenance
B0021861biological_processforebrain radial glial cell differentiation
B0030154biological_processcell differentiation
B0036396cellular_componentRNA N6-methyladenosine methyltransferase complex
B0042063biological_processgliogenesis
B0045664biological_processregulation of neuron differentiation
B0045727biological_processpositive regulation of translation
B0048255biological_processmRNA stabilization
B0060255biological_processregulation of macromolecule metabolic process
B0061157biological_processmRNA destabilization
B0080009biological_processobsolete mRNA methylation
B1901533biological_processnegative regulation of hematopoietic progenitor cell differentiation
B1904047molecular_functionS-adenosyl-L-methionine binding
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue NX8 A 601
ChainResidue
ACYS376
AGLY548
AASN549
AGLN550
AHOH719
AHOH747
AHOH775
AASP377
AILE378
AASP395
APRO397
ALEU409
ASER511
APHE534
AARG536

site_idAC2
Number of Residues5
Detailsbinding site for residue ACT B 501
ChainResidue
AGLU438
BARG249
BARG254
BARG255
BHOH616

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsSITE: Interaction with METTL3 => ECO:0000269|PubMed:27281194, ECO:0007744|PDB:5IL0, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2
ChainResidueDetails
BTYR146
BASP242
BARG245
BARG298
BSER399

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:29348140, ECO:0007744|PDB:5IL0, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2, ECO:0007744|PubMed:24275569
ChainResidueDetails
BSER399
ALYS513

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Interaction with METTL14 => ECO:0000269|PubMed:27281194, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2
ChainResidueDetails
AARG441
AGLU438

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine; alternate => ECO:0000269|PubMed:29348140
ChainResidueDetails
ASER2

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:29348140, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER43

site_idSWS_FT_FI6
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:29348140
ChainResidueDetails
ASER50
ASER350
ASER48

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:29348140, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER219

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:29348140, ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER243

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:29348140, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR348

site_idSWS_FT_FI10
Number of Residues5
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000269|PubMed:29506078
ChainResidueDetails
ALYS177
ALYS211
ALYS212
ALYS215

221051

PDB entries from 2024-06-12

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