6TTB

Crystal structure of NAD-dependent formate dehydrogenase from Staphylococcus aureus in complex with NAD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0008720	molecular_function	D-lactate dehydrogenase activity
A	0008863	molecular_function	formate dehydrogenase (NAD+) activity
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0051287	molecular_function	NAD binding
B	0000166	molecular_function	nucleotide binding
B	0008720	molecular_function	D-lactate dehydrogenase activity
B	0008863	molecular_function	formate dehydrogenase (NAD+) activity
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	binding site for residue NAD A 401

Chain	Residue
A	PHE95
A	PRO219
A	HIS246
A	ALA247
A	PRO248
A	GLU252
A	THR253
A	THR274
A	ARG276
A	ASP300
A	HIS324
A	ASN143
A	SER326
A	GLY327
A	HOH502
A	HOH504
A	VAL147
A	PHE194
A	GLY197
A	ARG198
A	ILE199
A	TYR217
A	ASP218

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Functional Information from PROSITE/UniProt

site_id	PS00065
Number of Residues	28
Details	D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. IGIFGfGRIGqlvaerlapfnvt.LQhYD

Chain	Residue	Details
A	ILE191-ASP218

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site_id	PS00670
Number of Residues	23
Details	D_2_HYDROXYACID_DH_2 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. LVssSDAItIHaPltpeTdnLfD

Chain	Residue	Details
A	LEU236-ASP258

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