6TS5
Coagulation factor XI protease domain in complex with active site inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue NW2 A 301 |
| Chain | Residue |
| A | HIS57 |
| A | TRP215 |
| A | GLY216 |
| A | GLY218 |
| A | CYS219 |
| A | HOH478 |
| A | HOH489 |
| A | HOH621 |
| A | LEU146 |
| A | ASP189 |
| A | ALA190 |
| A | CYS191 |
| A | LYS192 |
| A | GLY193 |
| A | SER195 |
| A | THR213 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | HIS178 |
| A | HOH423 |
| A | HOH483 |
| A | HOH557 |
| A | HOH584 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | GLN93 |
| A | TYR101 |
| A | ASP135 |
| A | TRP137 |
| A | LYS179 |
| A | LYS202 |
| A | HOH402 |
| A | HOH404 |
| A | HOH440 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 304 |
| Chain | Residue |
| A | LYS127 |
| A | GLY128 |
| A | ASP129 |
| A | ARG130 |
| A | HOH413 |
| A | HOH434 |
| A | HOH459 |
| A | HOH506 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 305 |
| Chain | Residue |
| A | PRO161 |
| A | TYR184 |
| A | ARG185 |
| A | HOH465 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue DMS A 306 |
| Chain | Residue |
| A | TYR172 |
| A | ARG173 |
| A | GLY173 |
| A | HIS174 |
| A | HOH410 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 235 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25092234","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1998667","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25092234","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
