6TS4
Coagulation factor XI protease domain in complex with active site inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 301 |
| Chain | Residue |
| A | THR177 |
| A | HOH626 |
| A | HIS178 |
| A | DMS308 |
| A | HOH455 |
| A | HOH460 |
| A | HOH474 |
| A | HOH478 |
| A | HOH516 |
| A | HOH547 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | LYS127 |
| A | GLY128 |
| A | ASP129 |
| A | ARG130 |
| A | HOH414 |
| A | HOH441 |
| A | HOH505 |
| A | HOH523 |
| A | HOH554 |
| A | HOH571 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | GLN93 |
| A | TYR101 |
| A | ASP135 |
| A | TRP137 |
| A | LYS179 |
| A | LYS202 |
| A | HOH407 |
| A | HOH448 |
| A | HOH620 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 304 |
| Chain | Residue |
| A | THR164 |
| A | ASN165 |
| A | GLU166 |
| A | HIS178 |
| A | HOH546 |
| A | HOH660 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 305 |
| Chain | Residue |
| A | TYR133 |
| A | LEU162 |
| A | ILE181 |
| A | ASN230 |
| A | HOH479 |
| A | HOH541 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 306 |
| Chain | Residue |
| A | PHE82 |
| A | PHE83 |
| A | THR110 |
| A | HOH495 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue DMS A 307 |
| Chain | Residue |
| A | HIS202 |
| A | ASN202 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 308 |
| Chain | Residue |
| A | GLY25 |
| A | GLU26 |
| A | SO4301 |
| A | HOH455 |
| A | HOH513 |
| A | HOH619 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue NA A 309 |
| Chain | Residue |
| A | GLU233 |
| A | TYR234 |
| A | ASP236 |
| A | TRP237 |
| A | HOH488 |
| A | HOH615 |
| A | HOH659 |
| site_id | AD1 |
| Number of Residues | 12 |
| Details | binding site for residue J7B A 310 |
| Chain | Residue |
| A | HIS57 |
| A | ASP189 |
| A | ALA190 |
| A | CYS191 |
| A | LYS192 |
| A | GLY193 |
| A | ASP194 |
| A | ALA195 |
| A | TRP215 |
| A | GLY216 |
| A | GLY218 |
| A | HOH602 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| A | LEU53-CYS58 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 235 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25092234","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1998667","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25092234","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
