6TQR
The crystal structure of the MSP domain of human VAP-A in complex with the Phospho-FFAT motif of STARD3.
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 301 |
| Chain | Residue |
| A | SER43 |
| A | ASP44 |
| A | ARG45 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 302 |
| Chain | Residue |
| A | PRO20 |
| A | THR21 |
| A | ASP22 |
| A | HOH477 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 303 |
| Chain | Residue |
| B | ASN64 |
| A | ARG62 |
| B | VAL61 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue CL C 301 |
| Chain | Residue |
| C | SER43 |
| C | ASP44 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 302 |
| Chain | Residue |
| C | ARG62 |
| D | VAL61 |
| D | ASN64 |
| D | HOH414 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue CL D 301 |
| Chain | Residue |
| B | LYS94 |
| B | LYS125 |
| D | GLU12 |
| D | GLN13 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue CL D 302 |
| Chain | Residue |
| B | GLU12 |
| B | GLN13 |
| D | LYS94 |
| D | LYS125 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 468 |
| Details | Domain: {"description":"MSP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00132","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Region: {"description":"phosphorylated FFAT motif binding","evidences":[{"source":"PubMed","id":"33124732","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TQR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Involved in binding the phosphorylated serine of the phospho-FFAT motif","evidences":[{"source":"PubMed","id":"33124732","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
