Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6TQO

rrn anti-termination complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001000	molecular_function	bacterial-type RNA polymerase core enzyme binding
A	0003676	molecular_function	nucleic acid binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006353	biological_process	DNA-templated transcription termination
A	0008023	cellular_component	transcription elongation factor complex
A	0019904	molecular_function	protein domain specific binding
A	0031554	biological_process	regulation of termination of DNA-templated transcription
A	0031564	biological_process	transcription antitermination
A	0032784	biological_process	regulation of DNA-templated transcription elongation
A	0042254	biological_process	ribosome biogenesis
A	0051259	biological_process	protein complex oligomerization
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006353	biological_process	DNA-templated transcription termination
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008023	cellular_component	transcription elongation factor complex
B	0031564	biological_process	transcription antitermination
B	0032784	biological_process	regulation of DNA-templated transcription elongation
B	0042254	biological_process	ribosome biogenesis
C	0000028	biological_process	ribosomal small subunit assembly
C	0000900	molecular_function	mRNA regulatory element binding translation repressor activity
C	0002181	biological_process	cytoplasmic translation
C	0003723	molecular_function	RNA binding
C	0003735	molecular_function	structural constituent of ribosome
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005840	cellular_component	ribosome
C	0006353	biological_process	DNA-templated transcription termination
C	0006412	biological_process	translation
C	0006417	biological_process	regulation of translation
C	0015935	cellular_component	small ribosomal subunit
C	0019843	molecular_function	rRNA binding
C	0022627	cellular_component	cytosolic small ribosomal subunit
C	0031564	biological_process	transcription antitermination
C	0042254	biological_process	ribosome biogenesis
C	0042274	biological_process	ribosomal small subunit biogenesis
C	0045947	biological_process	negative regulation of translational initiation
C	0046677	biological_process	response to antibiotic
C	0048027	molecular_function	mRNA 5'-UTR binding
C	1990145	biological_process	maintenance of translational fidelity
C	1990904	cellular_component	ribonucleoprotein complex
E	0000049	molecular_function	tRNA binding
E	0001072	molecular_function	transcription antitermination factor activity, RNA binding
E	0002181	biological_process	cytoplasmic translation
E	0003723	molecular_function	RNA binding
E	0003735	molecular_function	structural constituent of ribosome
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005840	cellular_component	ribosome
E	0006412	biological_process	translation
E	0008023	cellular_component	transcription elongation factor complex
E	0015935	cellular_component	small ribosomal subunit
E	0022627	cellular_component	cytosolic small ribosomal subunit
E	0031564	biological_process	transcription antitermination
E	0032784	biological_process	regulation of DNA-templated transcription elongation
E	0042254	biological_process	ribosome biogenesis
E	1990904	cellular_component	ribonucleoprotein complex
G	0005515	molecular_function	protein binding
G	0005829	cellular_component	cytosol
G	0006353	biological_process	DNA-templated transcription termination
G	0006354	biological_process	DNA-templated transcription elongation
G	0008023	cellular_component	transcription elongation factor complex
G	0031564	biological_process	transcription antitermination
G	0032784	biological_process	regulation of DNA-templated transcription elongation
G	0042254	biological_process	ribosome biogenesis
S	0000287	molecular_function	magnesium ion binding
S	0001072	molecular_function	transcription antitermination factor activity, RNA binding
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0006020	biological_process	inositol metabolic process
S	0007165	biological_process	signal transduction
S	0008934	molecular_function	inositol monophosphate 1-phosphatase activity
S	0016787	molecular_function	hydrolase activity
S	0016791	molecular_function	phosphatase activity
S	0031403	molecular_function	lithium ion binding
S	0031564	biological_process	transcription antitermination
S	0042134	molecular_function	rRNA primary transcript binding
S	0042254	biological_process	ribosome biogenesis
S	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
S	0046872	molecular_function	metal ion binding
S	0047954	molecular_function	glycerol-2-phosphatase activity
S	0052832	molecular_function	inositol monophosphate 3-phosphatase activity
S	0052834	molecular_function	inositol monophosphate phosphatase activity
T	0000287	molecular_function	magnesium ion binding
T	0001072	molecular_function	transcription antitermination factor activity, RNA binding
T	0003723	molecular_function	RNA binding
T	0005515	molecular_function	protein binding
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0006020	biological_process	inositol metabolic process
T	0007165	biological_process	signal transduction
T	0008934	molecular_function	inositol monophosphate 1-phosphatase activity
T	0016787	molecular_function	hydrolase activity
T	0016791	molecular_function	phosphatase activity
T	0031403	molecular_function	lithium ion binding
T	0031564	biological_process	transcription antitermination
T	0042134	molecular_function	rRNA primary transcript binding
T	0042254	biological_process	ribosome biogenesis
T	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
T	0046872	molecular_function	metal ion binding
T	0047954	molecular_function	glycerol-2-phosphatase activity
T	0052832	molecular_function	inositol monophosphate 3-phosphatase activity
T	0052834	molecular_function	inositol monophosphate phosphatase activity
U	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
U	0000428	cellular_component	DNA-directed RNA polymerase complex
U	0003677	molecular_function	DNA binding
U	0003899	molecular_function	DNA-directed RNA polymerase activity
U	0005515	molecular_function	protein binding
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0006351	biological_process	DNA-templated transcription
U	0006352	biological_process	DNA-templated transcription initiation
U	0006879	biological_process	intracellular iron ion homeostasis
U	0008023	cellular_component	transcription elongation factor complex
U	0009408	biological_process	response to heat
U	0016020	cellular_component	membrane
U	0016740	molecular_function	transferase activity
U	0016779	molecular_function	nucleotidyltransferase activity
U	0031564	biological_process	transcription antitermination
U	0032784	biological_process	regulation of DNA-templated transcription elongation
U	0034062	molecular_function	5'-3' RNA polymerase activity
U	0036460	biological_process	cellular response to cell envelope stress
U	0042128	biological_process	nitrate assimilation
U	0044780	biological_process	bacterial-type flagellum assembly
U	0046983	molecular_function	protein dimerization activity
U	0048870	biological_process	cell motility
U	0071973	biological_process	bacterial-type flagellum-dependent cell motility
U	0090605	biological_process	submerged biofilm formation
U	2000142	biological_process	regulation of DNA-templated transcription initiation
V	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
V	0000428	cellular_component	DNA-directed RNA polymerase complex
V	0003677	molecular_function	DNA binding
V	0003899	molecular_function	DNA-directed RNA polymerase activity
V	0005515	molecular_function	protein binding
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0006351	biological_process	DNA-templated transcription
V	0006352	biological_process	DNA-templated transcription initiation
V	0006879	biological_process	intracellular iron ion homeostasis
V	0008023	cellular_component	transcription elongation factor complex
V	0009408	biological_process	response to heat
V	0016020	cellular_component	membrane
V	0016740	molecular_function	transferase activity
V	0016779	molecular_function	nucleotidyltransferase activity
V	0031564	biological_process	transcription antitermination
V	0032784	biological_process	regulation of DNA-templated transcription elongation
V	0034062	molecular_function	5'-3' RNA polymerase activity
V	0036460	biological_process	cellular response to cell envelope stress
V	0042128	biological_process	nitrate assimilation
V	0044780	biological_process	bacterial-type flagellum assembly
V	0046983	molecular_function	protein dimerization activity
V	0048870	biological_process	cell motility
V	0071973	biological_process	bacterial-type flagellum-dependent cell motility
V	0090605	biological_process	submerged biofilm formation
V	2000142	biological_process	regulation of DNA-templated transcription initiation
W	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
W	0000428	cellular_component	DNA-directed RNA polymerase complex
W	0001000	molecular_function	bacterial-type RNA polymerase core enzyme binding
W	0003677	molecular_function	DNA binding
W	0003899	molecular_function	DNA-directed RNA polymerase activity
W	0005829	cellular_component	cytosol
W	0006351	biological_process	DNA-templated transcription
W	0006352	biological_process	DNA-templated transcription initiation
W	0006879	biological_process	intracellular iron ion homeostasis
W	0008023	cellular_component	transcription elongation factor complex
W	0009408	biological_process	response to heat
W	0016740	molecular_function	transferase activity
W	0016779	molecular_function	nucleotidyltransferase activity
W	0030880	cellular_component	RNA polymerase complex
W	0031564	biological_process	transcription antitermination
W	0032784	biological_process	regulation of DNA-templated transcription elongation
W	0034062	molecular_function	5'-3' RNA polymerase activity
W	0036460	biological_process	cellular response to cell envelope stress
W	0042128	biological_process	nitrate assimilation
W	0044780	biological_process	bacterial-type flagellum assembly
W	0048870	biological_process	cell motility
W	0065003	biological_process	protein-containing complex assembly
W	0071973	biological_process	bacterial-type flagellum-dependent cell motility
W	0090605	biological_process	submerged biofilm formation
W	2000142	biological_process	regulation of DNA-templated transcription initiation
X	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
X	0000428	cellular_component	DNA-directed RNA polymerase complex
X	0003677	molecular_function	DNA binding
X	0003899	molecular_function	DNA-directed RNA polymerase activity
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0006351	biological_process	DNA-templated transcription
X	0006352	biological_process	DNA-templated transcription initiation
X	0006879	biological_process	intracellular iron ion homeostasis
X	0008023	cellular_component	transcription elongation factor complex
X	0009408	biological_process	response to heat
X	0016020	cellular_component	membrane
X	0016740	molecular_function	transferase activity
X	0016779	molecular_function	nucleotidyltransferase activity
X	0031564	biological_process	transcription antitermination
X	0032549	molecular_function	ribonucleoside binding
X	0032784	biological_process	regulation of DNA-templated transcription elongation
X	0034062	molecular_function	5'-3' RNA polymerase activity
X	0036460	biological_process	cellular response to cell envelope stress
X	0042128	biological_process	nitrate assimilation
X	0044780	biological_process	bacterial-type flagellum assembly
X	0046677	biological_process	response to antibiotic
X	0048870	biological_process	cell motility
X	0071973	biological_process	bacterial-type flagellum-dependent cell motility
X	0090605	biological_process	submerged biofilm formation
X	2000142	biological_process	regulation of DNA-templated transcription initiation
Y	0000287	molecular_function	magnesium ion binding
Y	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
Y	0000428	cellular_component	DNA-directed RNA polymerase complex
Y	0003677	molecular_function	DNA binding
Y	0003899	molecular_function	DNA-directed RNA polymerase activity
Y	0005515	molecular_function	protein binding
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0006351	biological_process	DNA-templated transcription
Y	0006352	biological_process	DNA-templated transcription initiation
Y	0006879	biological_process	intracellular iron ion homeostasis
Y	0008023	cellular_component	transcription elongation factor complex
Y	0008270	molecular_function	zinc ion binding
Y	0009408	biological_process	response to heat
Y	0016020	cellular_component	membrane
Y	0016740	molecular_function	transferase activity
Y	0016779	molecular_function	nucleotidyltransferase activity
Y	0031564	biological_process	transcription antitermination
Y	0032784	biological_process	regulation of DNA-templated transcription elongation
Y	0034062	molecular_function	5'-3' RNA polymerase activity
Y	0036460	biological_process	cellular response to cell envelope stress
Y	0042128	biological_process	nitrate assimilation
Y	0044780	biological_process	bacterial-type flagellum assembly
Y	0046677	biological_process	response to antibiotic
Y	0046872	molecular_function	metal ion binding
Y	0048870	biological_process	cell motility
Y	0071973	biological_process	bacterial-type flagellum-dependent cell motility
Y	0090605	biological_process	submerged biofilm formation
Y	2000142	biological_process	regulation of DNA-templated transcription initiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue MG T 301

Chain	Residue
T	GLU67
T	ASP84
T	LEU86

site_id	AC2
Number of Residues	3
Details	binding site for residue MG S 301

Chain	Residue
S	GLU67
S	ASP84
S	LEU86

site_id	AC3
Number of Residues	6
Details	binding site for residue ZN Y 1501

Chain	Residue
Y	ASP889
Y	CYS895
Y	CYS898
Y	CYS814
Y	ARG883
Y	CYS888

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN Y 1502

Chain	Residue
Y	CYS70
Y	CYS72
Y	CYS85
Y	CYS88

site_id	AC5
Number of Residues	4
Details	binding site for residue MG Y 1503

Chain	Residue
R	C85
Y	ASP460
Y	ASP462
Y	ASP464

Functional Information from PROSITE/UniProt

site_id	PS00361
Number of Residues	16
Details	RIBOSOMAL_S10 Ribosomal protein S10 signature. AkrtGAqvrGPIpLPT

Chain	Residue	Details
E	ALA29-THR44

site_id	PS00629
Number of Residues	14
Details	IMP_1 Inositol monophosphatase family signature 1. WvIDPLDGTtnFiK

Chain	Residue	Details
T	TRP81-LYS94
S	TRP81-LYS94

site_id	PS00630
Number of Residues	15
Details	IMP_2 Inositol monophosphatase family signature 2. WDfAAGeLLVreaGG

Chain	Residue	Details
T	TRP211-GLY225
S	TRP211-GLY225

site_id	PS00632
Number of Residues	25
Details	RIBOSOMAL_S4 Ribosomal protein S4 signature. LEgRLdnvVYRmafGaTraeARqLV

Chain	Residue	Details
C	LEU94-VAL118

site_id	PS01014
Number of Residues	10
Details	NUSG Transcription termination factor nusG signature. IFGRaTPVeL

Chain	Residue	Details
G	ILE164-LEU173

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKMAGrHGNKGV

Chain	Residue	Details
X	GLY1063-VAL1075

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31020314","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32871103","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	65
Details	Domain: {"description":"S1 motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00945","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	63
Details	Domain: {"description":"KH 1","evidences":[{"source":"HAMAP-Rule","id":"MF_00945","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	66
Details	Domain: {"description":"KH 2","evidences":[{"source":"HAMAP-Rule","id":"MF_00945","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	50
Details	Repeat: {"description":"1"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	50
Details	Repeat: {"description":"2"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	136
Details	Region: {"description":"N-terminal domain (NTD) interacts with RNAP","evidences":[{"source":"PubMed","id":"21922055","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	81
Details	Region: {"description":"Acidic repeat 1 (AR1)","evidences":[{"source":"PubMed","id":"21922055","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	125
Details	Region: {"description":"2 X 51 AA approximate repeats"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	68
Details	Region: {"description":"Acidic repeat 2 (AR2), required for interaction with SuhB, interacts with RNAP subunit alpha (rpoA), NusG","evidences":[{"source":"PubMed","id":"31020314","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31127279","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21922055","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	31
Details	Domain: {"description":"KOW","evidences":[{"source":"HAMAP-Rule","id":"MF_00948","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	3
Details	Region: {"description":"Required for interaction with Crp at class II promoters"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"ADP-ribosylarginine","evidences":[{"source":"PubMed","id":"4371081","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"21696463","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; by PatZ","evidences":[{"source":"PubMed","id":"21696463","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"HAMAP-Rule","id":"MF_01321","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32871103","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MEY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	60
Details	Domain: {"description":"S4 RNA-binding"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)