6TQH
Escherichia coli AdhE structure in its extended conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006066 | biological_process | alcohol metabolic process |
| A | 0006115 | biological_process | ethanol biosynthetic process |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0008198 | molecular_function | ferrous iron binding |
| A | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
| A | 0015976 | biological_process | carbon utilization |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019664 | biological_process | mixed acid fermentation |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051260 | biological_process | protein homooligomerization |
| A | 0120542 | molecular_function | ethanol dehydrogenase (NAD+) activity |
| B | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006066 | biological_process | alcohol metabolic process |
| B | 0006115 | biological_process | ethanol biosynthetic process |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0008198 | molecular_function | ferrous iron binding |
| B | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
| B | 0015976 | biological_process | carbon utilization |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019664 | biological_process | mixed acid fermentation |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051260 | biological_process | protein homooligomerization |
| B | 0120542 | molecular_function | ethanol dehydrogenase (NAD+) activity |
| C | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0006066 | biological_process | alcohol metabolic process |
| C | 0006115 | biological_process | ethanol biosynthetic process |
| C | 0006979 | biological_process | response to oxidative stress |
| C | 0008198 | molecular_function | ferrous iron binding |
| C | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
| C | 0015976 | biological_process | carbon utilization |
| C | 0016020 | cellular_component | membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0019664 | biological_process | mixed acid fermentation |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051260 | biological_process | protein homooligomerization |
| C | 0120542 | molecular_function | ethanol dehydrogenase (NAD+) activity |
| F | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005829 | cellular_component | cytosol |
| F | 0006066 | biological_process | alcohol metabolic process |
| F | 0006115 | biological_process | ethanol biosynthetic process |
| F | 0006979 | biological_process | response to oxidative stress |
| F | 0008198 | molecular_function | ferrous iron binding |
| F | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
| F | 0015976 | biological_process | carbon utilization |
| F | 0016020 | cellular_component | membrane |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0019664 | biological_process | mixed acid fermentation |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0051260 | biological_process | protein homooligomerization |
| F | 0120542 | molecular_function | ethanol dehydrogenase (NAD+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue NAD A 901 |
| Chain | Residue |
| A | ASP487 |
| A | SER603 |
| A | THR606 |
| A | PHE608 |
| A | VAL610 |
| A | LYS619 |
| A | LEU638 |
| A | MET642 |
| A | LEU646 |
| A | HIS657 |
| A | PHE714 |
| A | PHE489 |
| A | HIS723 |
| A | HIS737 |
| A | FE903 |
| A | GLY545 |
| A | GLY546 |
| A | SER547 |
| A | ASP550 |
| A | THR597 |
| A | THR598 |
| A | THR601 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | binding site for residue NAD A 902 |
| Chain | Residue |
| A | ILE110 |
| A | VAL111 |
| A | THR113 |
| A | THR114 |
| A | ASN115 |
| A | HIS139 |
| A | SER178 |
| A | MET182 |
| A | GLY194 |
| A | GLY195 |
| A | MET198 |
| A | ALA201 |
| A | VAL212 |
| A | GLY213 |
| A | ALA214 |
| A | CYS246 |
| A | GLU335 |
| A | HIS367 |
| A | THR418 |
| A | LEU419 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue FE A 903 |
| Chain | Residue |
| A | ASP653 |
| A | HIS657 |
| A | HIS723 |
| A | HIS737 |
| A | ASN741 |
| A | NAD901 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | binding site for residue NAD B 901 |
| Chain | Residue |
| B | VAL111 |
| B | PRO112 |
| B | THR113 |
| B | HIS139 |
| B | MET182 |
| B | THR193 |
| B | GLY194 |
| B | MET198 |
| B | ALA201 |
| B | VAL212 |
| B | GLY213 |
| B | ALA214 |
| B | CYS246 |
| B | GLU335 |
| B | HIS367 |
| B | THR418 |
| B | LEU419 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | binding site for residue NAD B 902 |
| Chain | Residue |
| B | ASP487 |
| B | PHE489 |
| B | ASP519 |
| B | GLY545 |
| B | GLY546 |
| B | SER547 |
| B | ASP550 |
| B | THR597 |
| B | THR598 |
| B | THR601 |
| B | SER603 |
| B | THR606 |
| B | PHE608 |
| B | VAL610 |
| B | LYS619 |
| B | LEU638 |
| B | MET642 |
| B | LEU646 |
| B | PHE714 |
| B | HIS737 |
| B | FE903 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue FE B 903 |
| Chain | Residue |
| B | ASP653 |
| B | HIS657 |
| B | HIS723 |
| B | HIS737 |
| B | ASN741 |
| B | NAD902 |
Functional Information from PROSITE/UniProt
| site_id | PS00060 |
| Number of Residues | 21 |
| Details | ADH_IRON_2 Iron-containing alcohol dehydrogenases signature 2. GvCHsmAHkLGSqfhIpHGlA |
| Chain | Residue | Details |
| A | GLY720-ALA740 |
| site_id | PS00913 |
| Number of Residues | 29 |
| Details | ADH_IRON_1 Iron-containing alcohol dehydrogenases signature 1. AIvDanlvmdmPkslcAfGglDAVthamE |
| Chain | Residue | Details |
| A | ALA632-GLU660 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 876 |
| Details | Region: {"description":"Aldehyde dehydrogenase","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Region: {"description":"Linker","evidences":[{"source":"PubMed","id":"31586059","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"Q9HTJ1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 50 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32523125","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7BVP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32188856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32523125","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6TQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TQM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
