6TPN

Crystal structure of the Orexin-2 receptor in complex with HTL6641 at 2.61 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007631	biological_process	feeding behavior
A	0016020	cellular_component	membrane
A	0016499	molecular_function	orexin receptor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue NU8 A 1201

Chain	Residue
A	THR111
A	TYR317
A	ILE320
A	ASN324
A	HIS350
A	TYR354
A	PRO131
A	GLN134
A	THR135
A	VAL138
A	GLN187
A	CYS210
A	HIS224
A	PHE227

---

site_id	AC2
Number of Residues	2
Details	binding site for residue NO3 A 1203

Chain	Residue
A	ASP1180
A	LEU1181

---

site_id	AC3
Number of Residues	5
Details	binding site for residue PG4 A 1204

Chain	Residue
A	ASP211
A	LYS327
A	ARG328
A	PHE333
A	PHE346

---

site_id	AC4
Number of Residues	6
Details	binding site for residue PG4 A 1205

Chain	Residue
A	TRP44
A	PRO159
A	ARG1147
A	ILE1156
A	LEU1157
A	LYS1172

---

site_id	AC5
Number of Residues	2
Details	binding site for residue OLA A 1206

Chain	Residue
A	VAL56
A	LEU57

---

site_id	AC6
Number of Residues	2
Details	binding site for residue OLA A 1207

Chain	Residue
A	SER125
A	ILE189

---

site_id	AC7
Number of Residues	3
Details	binding site for residue OLA A 1208

Chain	Residue
A	CYS147
A	SER172
A	VAL230

---

site_id	AC8
Number of Residues	5
Details	binding site for residue OLA A 1209

Chain	Residue
A	GLU46
A	TRP153
A	TYR154
A	HIS158
A	GLN245

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VSAlTLSCIALDRWYaI

Chain	Residue	Details
A	VAL140-ILE156

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	53
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:25533960, ECO:0000305|PubMed:26950369

Chain	Residue	Details
A	MET1-ALA54

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	TRP55-VAL75

---

site_id	SWS_FT_FI3
Number of Residues	31
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	CYS76-VAL88
A	ASP151-LEU170

---

site_id	SWS_FT_FI4
Number of Residues	21
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	THR89-ALA110

---

site_id	SWS_FT_FI5
Number of Residues	61
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	GLU192-MET222
A	LYS327-VAL342
A	THR111-CYS127

---

site_id	SWS_FT_FI6
Number of Residues	22
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	LYS128-LEU150

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	ASN171-MET191

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	TYR223-TYR243

---

site_id	SWS_FT_FI9
Number of Residues	21
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	MET305-LEU326

---

site_id	SWS_FT_FI10
Number of Residues	23
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	TYR343-PHE366

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:25533960, ECO:0007744|PDB:4S0V

Chain	Residue	Details
A	ASN324

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	SITE: Important for responses to orexin => ECO:0000269|PubMed:26950369

Chain	Residue	Details
A	TRP44

---

site_id	SWS_FT_FI13
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASP14
A	ASP22
A	ASP202

---