Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007631 | biological_process | feeding behavior |
| A | 0016020 | cellular_component | membrane |
| A | 0016499 | molecular_function | orexin receptor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue NU8 A 1201 |
| Chain | Residue |
| A | THR111 |
| A | TYR317 |
| A | ILE320 |
| A | ASN324 |
| A | HIS350 |
| A | TYR354 |
| A | PRO131 |
| A | GLN134 |
| A | THR135 |
| A | VAL138 |
| A | GLN187 |
| A | CYS210 |
| A | HIS224 |
| A | PHE227 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue NO3 A 1203 |
| Chain | Residue |
| A | ASP1180 |
| A | LEU1181 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue PG4 A 1204 |
| Chain | Residue |
| A | ASP211 |
| A | LYS327 |
| A | ARG328 |
| A | PHE333 |
| A | PHE346 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue PG4 A 1205 |
| Chain | Residue |
| A | TRP44 |
| A | PRO159 |
| A | ARG1147 |
| A | ILE1156 |
| A | LEU1157 |
| A | LYS1172 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue OLA A 1206 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue OLA A 1207 |
| Chain | Residue |
| A | SER125 |
| A | ILE189 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue OLA A 1208 |
| Chain | Residue |
| A | CYS147 |
| A | SER172 |
| A | VAL230 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue OLA A 1209 |
| Chain | Residue |
| A | GLU46 |
| A | TRP153 |
| A | TYR154 |
| A | HIS158 |
| A | GLN245 |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VSAlTLSCIALDRWYaI |
| Chain | Residue | Details |
| A | VAL140-ILE156 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 31 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 31 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI9 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI10 |
| Number of Residues | 16 |
| Details | Region: {"description":"Required for response to orexin-A","evidences":[{"source":"PubMed","id":"26950369","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4S0V","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for responses to orexin","evidences":[{"source":"PubMed","id":"26950369","evidenceCode":"ECO:0000269"}]} |
