6TPJ

Crystal structure of the Orexin-2 receptor in complex with suvorexant at 2.76 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007631	biological_process	feeding behavior
A	0016020	cellular_component	membrane
A	0016499	molecular_function	orexin receptor activity
B	0004930	molecular_function	G protein-coupled receptor activity
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007631	biological_process	feeding behavior
B	0016020	cellular_component	membrane
B	0016499	molecular_function	orexin receptor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue SUV A 1202

Chain	Residue
A	ALA110
A	GLU212
A	ILE320
A	ASN324
A	HIS350
A	HOH1324
A	HOH1340
A	THR111
A	VAL114
A	TRP120
A	ILE130
A	PRO131
A	GLN134
A	THR135
A	GLN187

---

site_id	AC2
Number of Residues	3
Details	binding site for residue OLA A 1204

Chain	Residue
A	TYR1120
A	ALA1142
A	VAL1143

---

site_id	AC3
Number of Residues	3
Details	binding site for residue OLA A 1205

Chain	Residue
A	ILE1038
A	NH41206
A	OLA1207

---

site_id	AC4
Number of Residues	1
Details	binding site for residue NH4 A 1206

Chain	Residue
A	OLA1205

---

site_id	AC5
Number of Residues	5
Details	binding site for residue OLA A 1207

Chain	Residue
A	ARG1040
A	LYS1074
A	GLU1098
A	MET1099
A	OLA1205

---

site_id	AC6
Number of Residues	4
Details	binding site for residue OLA A 1208

Chain	Residue
A	GLU52
A	THR341
A	ALA344
B	OLA2108

---

site_id	AC7
Number of Residues	1
Details	binding site for residue OLA A 1209

Chain	Residue
A	LEU74

---

site_id	AC8
Number of Residues	2
Details	binding site for residue OLA A 1210

Chain	Residue
A	TRP381
B	LYS1062

---

site_id	AC9
Number of Residues	2
Details	binding site for residue OLA A 1211

Chain	Residue
A	ILE182
A	ILE185

---

site_id	AD1
Number of Residues	1
Details	binding site for residue OLA A 1212

Chain	Residue
A	ASN171

---

site_id	AD2
Number of Residues	5
Details	binding site for residue OLA A 1213

Chain	Residue
A	LEU236
A	VAL240
A	TYR243
A	PHE247
A	MET307

---

site_id	AD3
Number of Residues	4
Details	binding site for residue OLA A 1214

Chain	Residue
A	GLY71
A	ASN365
A	PHE366
B	OLA2121

---

site_id	AD4
Number of Residues	4
Details	binding site for residue OLA A 1215

Chain	Residue
A	LYS221
A	VAL329
A	ARG1178
A	SER1179

---

site_id	AD5
Number of Residues	1
Details	binding site for residue OLA A 1216

Chain	Residue
A	LEU238

---

site_id	AD6
Number of Residues	3
Details	binding site for residue PG4 A 1217

Chain	Residue
A	CYS210
A	LYS327
A	PHE333

---

site_id	AD7
Number of Residues	14
Details	binding site for residue SUV B 2101

Chain	Residue
B	ALA110
B	THR111
B	VAL114
B	TRP120
B	ILE130
B	PRO131
B	GLN134
B	THR135
B	GLN187
B	GLU212
B	PHE227
B	ILE320
B	ASN324
B	HIS350

---

site_id	AD8
Number of Residues	1
Details	binding site for residue NH4 B 2102

Chain	Residue
B	LEU1126

---

site_id	AD9
Number of Residues	2
Details	binding site for residue OLA B 2105

Chain	Residue
B	GLU1018
B	SER1022

---

site_id	AE1
Number of Residues	3
Details	binding site for residue OLA B 2106

Chain	Residue
B	CYS157
B	ARG253
B	PRO1123

---

site_id	AE2
Number of Residues	2
Details	binding site for residue OLA B 2108

Chain	Residue
A	OLA1208
B	ASN171

---

site_id	AE3
Number of Residues	3
Details	binding site for residue OLA B 2109

Chain	Residue
B	SER125
B	LYS128
B	GLN1065

---

site_id	AE4
Number of Residues	4
Details	binding site for residue OLA B 2111

Chain	Residue
B	VAL312
B	CYS316
B	ALA359
B	ILE362

---

site_id	AE5
Number of Residues	1
Details	binding site for residue OLA B 2112

Chain	Residue
B	LEU352

---

site_id	AE6
Number of Residues	2
Details	binding site for residue OLA B 2113

Chain	Residue
B	SER1060
B	LYS1089

---

site_id	AE7
Number of Residues	3
Details	binding site for residue OLA B 2115

Chain	Residue
B	PHE1121
B	PRO1123
B	GLY1144

---

site_id	AE8
Number of Residues	1
Details	binding site for residue OLA B 2116

Chain	Residue
B	LYS376

---

site_id	AE9
Number of Residues	2
Details	binding site for residue OLA B 2117

Chain	Residue
B	THR106
B	PHE122

---

site_id	AF1
Number of Residues	3
Details	binding site for residue OLA B 2118

Chain	Residue
B	PRO109
B	LEU112
B	THR117

---

site_id	AF2
Number of Residues	5
Details	binding site for residue OLA B 2119

Chain	Residue
B	LEU1100
B	ILE1038
B	ARG1040
B	ILE1072
B	LYS1074

---

site_id	AF3
Number of Residues	3
Details	binding site for residue OLA B 2121

Chain	Residue
A	OLA1214
B	ILE189
B	HOH2212

---

site_id	AF4
Number of Residues	2
Details	binding site for residue OLA B 2122

Chain	Residue
B	LEU69
B	ILE70

---

site_id	AF5
Number of Residues	1
Details	binding site for residue OLA B 2123

Chain	Residue
B	VAL67

---

site_id	AF6
Number of Residues	2
Details	binding site for residue OLA B 2124

Chain	Residue
B	PHE247
B	ARG304

---

site_id	AF7
Number of Residues	3
Details	binding site for residue OLA B 2125

Chain	Residue
B	PHE121
B	LYS1021
B	GLU1031

---

site_id	AF8
Number of Residues	5
Details	binding site for residue PG4 B 2126

Chain	Residue
B	LYS327
B	PHE333
B	PHE346
B	HOH2213
B	HOH2220

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VSAlTLSCIALDRWYaI

Chain	Residue	Details
A	VAL140-ILE156

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	62
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	122
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4S0V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---