6TOT

Crystal structure of the Orexin-1 receptor in complex with lemborexant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007631	biological_process	feeding behavior
A	0016020	cellular_component	membrane
A	0016499	molecular_function	orexin receptor activity
B	0004930	molecular_function	G protein-coupled receptor activity
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007631	biological_process	feeding behavior
B	0016020	cellular_component	membrane
B	0016499	molecular_function	orexin receptor activity

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VAVlTLSFIALDRWYaI

Chain	Residue	Details
A	VAL132-ILE148

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:26950369

Chain	Residue	Details
A	TRP47-VAL67
B	TRP47-VAL67

---

site_id	SWS_FT_FI2
Number of Residues	190
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26950369

Chain	Residue	Details
A	CYS68-ASN82
A	ALA141-ARG160
A	PHE236-ALA330
B	CYS68-ASN82
B	ALA141-ARG160
B	PHE236-ALA330

---

site_id	SWS_FT_FI3
Number of Residues	44
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:26950369

Chain	Residue	Details
A	TYR83-LEU105
B	TYR83-LEU105

---

site_id	SWS_FT_FI4
Number of Residues	114
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:26950369

Chain	Residue	Details
A	VAL106-CYS119
A	MET183-LYS213
A	ASN354-GLN368
B	VAL106-CYS119
B	MET183-LYS213
B	ASN354-GLN368

---

site_id	SWS_FT_FI5
Number of Residues	40
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:26950369

Chain	Residue	Details
A	LYS120-ILE140
B	LYS120-ILE140

---

site_id	SWS_FT_FI6
Number of Residues	42
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:26950369

Chain	Residue	Details
A	ALA161-VAL182
B	ALA161-VAL182

---

site_id	SWS_FT_FI7
Number of Residues	42
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:26950369

Chain	Residue	Details
A	ILE214-TYR235
B	ILE214-TYR235

---

site_id	SWS_FT_FI8
Number of Residues	44
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:26950369

Chain	Residue	Details
A	SER331-ALA353
B	SER331-ALA353

---

site_id	SWS_FT_FI9
Number of Residues	46
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:26950369

Chain	Residue	Details
A	PHE369-HIS392
B	PHE369-HIS392

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:26950369, ECO:0007744|PDB:4ZJ8

Chain	Residue	Details
A	ASN350
B	ASN350

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site_id	SWS_FT_FI11
Number of Residues	2
Details	SITE: Important for responses to orexin => ECO:0000269|PubMed:26950369

Chain	Residue	Details
A	TRP36
B	TRP36

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ALA194
B	ALA194

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