6TNQ

Crystal structure of the human Arc N-lobe bound to repeat 4 from GKAP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003729	molecular_function	mRNA binding
A	0050804	biological_process	modulation of chemical synaptic transmission
A	2000969	biological_process	positive regulation of AMPA receptor activity
C	0003729	molecular_function	mRNA binding
C	0050804	biological_process	modulation of chemical synaptic transmission
C	2000969	biological_process	positive regulation of AMPA receptor activity
E	0003729	molecular_function	mRNA binding
E	0050804	biological_process	modulation of chemical synaptic transmission
E	2000969	biological_process	positive regulation of AMPA receptor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for Di-peptide ACE D 301 and THR D 225

Chain	Residue
A	ARG218
A	GLU276
C	ASP210
C	GLN212
C	TYR227
D	SER226
D	HOH402
D	HOH403

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9D415

Chain	Residue	Details
D	SER226
F	SER226
B	SER226

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site_id	SWS_FT_FI2
Number of Residues	9
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:24945773

Chain	Residue	Details
A	LYS268
A	LYS269
C	LYS268
C	LYS269
E	LYS268
E	LYS269

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