6TNQ

Crystal structure of the human Arc N-lobe bound to repeat 4 from GKAP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003729	molecular_function	mRNA binding
A	0050804	biological_process	modulation of chemical synaptic transmission
A	2000969	biological_process	positive regulation of AMPA receptor activity
C	0003729	molecular_function	mRNA binding
C	0050804	biological_process	modulation of chemical synaptic transmission
C	2000969	biological_process	positive regulation of AMPA receptor activity
E	0003729	molecular_function	mRNA binding
E	0050804	biological_process	modulation of chemical synaptic transmission
E	2000969	biological_process	positive regulation of AMPA receptor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for Di-peptide ACE D 301 and THR D 225

Chain	Residue
A	ARG218
A	GLU276
C	ASP210
C	GLN212
C	TYR227
D	SER226
D	HOH402
D	HOH403

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9WV31","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	9
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"24945773","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9D415","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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