6TNM

E. coli aerobic trifunctional enzyme subunit-alpha

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
A	0004165	molecular_function	delta(3)-delta(2)-enoyl-CoA isomerase activity
A	0004300	molecular_function	enoyl-CoA hydratase activity
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006635	biological_process	fatty acid beta-oxidation
A	0008692	molecular_function	3-hydroxybutyryl-CoA epimerase activity
A	0009062	biological_process	fatty acid catabolic process
A	0016042	biological_process	lipid catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016509	molecular_function	long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0016829	molecular_function	lyase activity
A	0016853	molecular_function	isomerase activity
A	0018812	molecular_function	3-hydroxyacyl-CoA dehydratase activity
A	0036125	cellular_component	fatty acid beta-oxidation multienzyme complex
A	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL A 801

Chain	Residue
A	PHE73
A	GLU119
A	GLU139
A	ILE144
A	GLY147
A	PHE148
A	PHE277

---

site_id	AC2
Number of Residues	6
Details	binding site for residue ATP A 802

Chain	Residue
A	VAL400
A	VAL401
A	VAL406
A	LYS584
A	ASP343
A	ILE344

---

site_id	AC3
Number of Residues	3
Details	binding site for residue NO3 A 803

Chain	Residue
A	VAL66
A	ILE70
A	GLN297

---

site_id	AC4
Number of Residues	4
Details	binding site for residue NO3 A 804

Chain	Residue
A	GLY115
A	PRO138
A	GLU139
A	LEU142

---

site_id	AC5
Number of Residues	2
Details	binding site for residue NO3 A 805

Chain	Residue
A	PHE531
A	TRP674

---

site_id	AC6
Number of Residues	2
Details	binding site for residue NO3 A 807

Chain	Residue
A	PRO454
A	NO3809

---

site_id	AC7
Number of Residues	2
Details	binding site for residue NO3 A 808

Chain	Residue
A	ARG134
A	GLN177

---

site_id	AC8
Number of Residues	2
Details	binding site for residue NO3 A 809

Chain	Residue
A	ARG457
A	NO3807

---

Functional Information from PROSITE/UniProt

site_id	PS00067
Number of Residues	25
Details	3HCDH 3-hydroxyacyl-CoA dehydrogenase signature. DcpGFFvNRvlfPYFagfsq.LLrdG

Chain	Residue	Details
A	ASP493-GLY517

---

site_id	PS00166
Number of Residues	21
Details	ENOYL_COA_HYDRATASE Enoyl-CoA hydratase/isomerase signature. IAaVNGyalGGGcecvLaTDY

Chain	Residue	Details
A	ILE106-TYR126

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	188
Details	Region: {"description":"Enoyl-CoA hydratase/isomerase","evidences":[{"source":"HAMAP-Rule","id":"MF_01621","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"For 3-hydroxyacyl-CoA dehydrogenase activity","evidences":[{"source":"HAMAP-Rule","id":"MF_01621","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8454629","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8755745","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01621","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01621","evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Important for catalytic activity","evidences":[{"source":"HAMAP-Rule","id":"MF_01621","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---