6TMP

Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000166	molecular_function	nucleotide binding
AAA	0004672	molecular_function	protein kinase activity
AAA	0004740	molecular_function	pyruvate dehydrogenase (acetyl-transferring) kinase activity
AAA	0005515	molecular_function	protein binding
AAA	0005524	molecular_function	ATP binding
AAA	0005654	cellular_component	nucleoplasm
AAA	0005739	cellular_component	mitochondrion
AAA	0005759	cellular_component	mitochondrial matrix
AAA	0005829	cellular_component	cytosol
AAA	0006006	biological_process	glucose metabolic process
AAA	0006111	biological_process	regulation of gluconeogenesis
AAA	0006885	biological_process	regulation of pH
AAA	0008286	biological_process	insulin receptor signaling pathway
AAA	0010510	biological_process	regulation of pyruvate decarboxylation to acetyl-CoA
AAA	0010565	biological_process	regulation of ketone metabolic process
AAA	0010906	biological_process	regulation of glucose metabolic process
AAA	0016301	molecular_function	kinase activity
AAA	0016740	molecular_function	transferase activity
AAA	0031670	biological_process	cellular response to nutrient
AAA	0033554	biological_process	cellular response to stress
AAA	0034614	biological_process	cellular response to reactive oxygen species
AAA	0042593	biological_process	glucose homeostasis
AAA	0042803	molecular_function	protein homodimerization activity
AAA	0045254	cellular_component	pyruvate dehydrogenase complex
AAA	0050848	biological_process	regulation of calcium-mediated signaling
AAA	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	13
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16401071","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q15118","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8BFP9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

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