6TLU

HUMAN CK2 KINASE ALPHA SUBUNIT IN COMPLEX WITH THE ATP-COMPETITIVE INHIBITOR 4,5-DIBROMOBENZOTRIAZOLE

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000077	biological_process	DNA damage checkpoint signaling
AAA	0000166	molecular_function	nucleotide binding
AAA	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
AAA	0000724	biological_process	double-strand break repair via homologous recombination
AAA	0004672	molecular_function	protein kinase activity
AAA	0004674	molecular_function	protein serine/threonine kinase activity
AAA	0005515	molecular_function	protein binding
AAA	0005524	molecular_function	ATP binding
AAA	0005634	cellular_component	nucleus
AAA	0005654	cellular_component	nucleoplasm
AAA	0005829	cellular_component	cytosol
AAA	0005886	cellular_component	plasma membrane
AAA	0005956	cellular_component	protein kinase CK2 complex
AAA	0006302	biological_process	double-strand break repair
AAA	0006357	biological_process	regulation of transcription by RNA polymerase II
AAA	0006457	biological_process	protein folding
AAA	0006468	biological_process	protein phosphorylation
AAA	0006915	biological_process	apoptotic process
AAA	0006974	biological_process	DNA damage response
AAA	0007165	biological_process	signal transduction
AAA	0008284	biological_process	positive regulation of cell population proliferation
AAA	0016055	biological_process	Wnt signaling pathway
AAA	0016301	molecular_function	kinase activity
AAA	0016605	cellular_component	PML body
AAA	0016740	molecular_function	transferase activity
AAA	0017148	biological_process	negative regulation of translation
AAA	0030163	biological_process	protein catabolic process
AAA	0030177	biological_process	positive regulation of Wnt signaling pathway
AAA	0030307	biological_process	positive regulation of cell growth
AAA	0031519	cellular_component	PcG protein complex
AAA	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
AAA	0035973	biological_process	aggrephagy
AAA	0042176	biological_process	regulation of protein catabolic process
AAA	0042802	molecular_function	identical protein binding
AAA	0045732	biological_process	positive regulation of protein catabolic process
AAA	0045947	biological_process	negative regulation of translational initiation
AAA	0048511	biological_process	rhythmic process
AAA	0050821	biological_process	protein stabilization
AAA	0051726	biological_process	regulation of cell cycle
AAA	0051879	molecular_function	Hsp90 protein binding
AAA	0070822	cellular_component	Sin3-type complex
AAA	0071211	biological_process	protein targeting to vacuole involved in autophagy
AAA	0075342	biological_process	symbiont-mediated disruption of host cell PML body
AAA	0097194	biological_process	execution phase of apoptosis
AAA	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
AAA	0106310	molecular_function	protein serine kinase activity
AAA	0140694	biological_process	membraneless organelle assembly
AAA	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
AAA	1905337	biological_process	positive regulation of aggrephagy
AAA	1905818	biological_process	regulation of chromosome separation
AAA	1990166	biological_process	protein localization to site of double-strand break
AAA	2000042	biological_process	negative regulation of double-strand break repair via homologous recombination
AAA	2001234	biological_process	negative regulation of apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK

Chain	Residue	Details
AAA	LEU45-LYS68

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI

Chain	Residue	Details
AAA	ILE152-ILE164

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
AAA	ASP156

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
AAA	LEU45
AAA	LYS68

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by CDK1 => ECO:0000269|PubMed:7592773

Chain	Residue	Details
AAA	THR344
AAA	THR360

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:7592773

Chain	Residue	Details
AAA	SER362

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:7592773, ECO:0007744|PubMed:18691976

Chain	Residue	Details
AAA	SER370

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