6TJV

Structure of the NDH-1MS complex from Thermosynechococcus elongatus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003954	molecular_function	NADH dehydrogenase activity
A	0009060	biological_process	aerobic respiration
A	0016020	cellular_component	membrane
A	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
A	0019684	biological_process	photosynthesis, light reaction
A	0031676	cellular_component	plasma membrane-derived thylakoid membrane
A	0042651	cellular_component	thylakoid membrane
A	0048038	molecular_function	quinone binding
B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
B	0019684	biological_process	photosynthesis, light reaction
B	0031676	cellular_component	plasma membrane-derived thylakoid membrane
B	0042651	cellular_component	thylakoid membrane
B	0042773	biological_process	ATP synthesis coupled electron transport
B	0048038	molecular_function	quinone binding
B	1902600	biological_process	proton transmembrane transport
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
C	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
C	0019684	biological_process	photosynthesis, light reaction
C	0030964	cellular_component	NADH dehydrogenase complex
C	0031676	cellular_component	plasma membrane-derived thylakoid membrane
C	0042651	cellular_component	thylakoid membrane
C	0048038	molecular_function	quinone binding
C	1902600	biological_process	proton transmembrane transport
D	0003954	molecular_function	NADH dehydrogenase activity
D	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D	0009060	biological_process	aerobic respiration
D	0012505	cellular_component	endomembrane system
D	0015990	biological_process	electron transport coupled proton transport
D	0016020	cellular_component	membrane
D	0042773	biological_process	ATP synthesis coupled electron transport
D	0048039	molecular_function	ubiquinone binding
E	0016020	cellular_component	membrane
E	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
E	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
E	0019684	biological_process	photosynthesis, light reaction
E	0030964	cellular_component	NADH dehydrogenase complex
E	0031676	cellular_component	plasma membrane-derived thylakoid membrane
E	0042651	cellular_component	thylakoid membrane
E	0042773	biological_process	ATP synthesis coupled electron transport
E	0048038	molecular_function	quinone binding
F	0003954	molecular_function	NADH dehydrogenase activity
F	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
F	0012505	cellular_component	endomembrane system
F	0015990	biological_process	electron transport coupled proton transport
F	0016020	cellular_component	membrane
F	0042773	biological_process	ATP synthesis coupled electron transport
G	0005886	cellular_component	plasma membrane
G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
G	0048038	molecular_function	quinone binding
G	1902495	cellular_component	transmembrane transporter complex
G	1902600	biological_process	proton transmembrane transport
H	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
H	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
H	0019684	biological_process	photosynthesis, light reaction
H	0031676	cellular_component	plasma membrane-derived thylakoid membrane
H	0042651	cellular_component	thylakoid membrane
H	0048038	molecular_function	quinone binding
H	0051287	molecular_function	NAD binding
I	0005506	molecular_function	iron ion binding
I	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
I	0016020	cellular_component	membrane
I	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
I	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
I	0019684	biological_process	photosynthesis, light reaction
I	0031676	cellular_component	plasma membrane-derived thylakoid membrane
I	0042651	cellular_component	thylakoid membrane
I	0046872	molecular_function	metal ion binding
I	0048038	molecular_function	quinone binding
I	0051536	molecular_function	iron-sulfur cluster binding
I	0051539	molecular_function	4 iron, 4 sulfur cluster binding
I	1902600	biological_process	proton transmembrane transport
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
J	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
J	0019684	biological_process	photosynthesis, light reaction
J	0031676	cellular_component	plasma membrane-derived thylakoid membrane
J	0042651	cellular_component	thylakoid membrane
J	0048038	molecular_function	quinone binding
J	1902600	biological_process	proton transmembrane transport
K	0005506	molecular_function	iron ion binding
K	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
K	0009060	biological_process	aerobic respiration
K	0015990	biological_process	electron transport coupled proton transport
K	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
K	0019684	biological_process	photosynthesis, light reaction
K	0031676	cellular_component	plasma membrane-derived thylakoid membrane
K	0042651	cellular_component	thylakoid membrane
K	0045271	cellular_component	respiratory chain complex I
K	0046872	molecular_function	metal ion binding
K	0048038	molecular_function	quinone binding
K	0051536	molecular_function	iron-sulfur cluster binding
K	0051539	molecular_function	4 iron, 4 sulfur cluster binding
L	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
L	0031676	cellular_component	plasma membrane-derived thylakoid membrane
L	0042651	cellular_component	thylakoid membrane
L	0048038	molecular_function	quinone binding
M	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
M	0031676	cellular_component	plasma membrane-derived thylakoid membrane
M	0042651	cellular_component	thylakoid membrane
M	0048038	molecular_function	quinone binding
N	0016020	cellular_component	membrane
N	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
N	0031676	cellular_component	plasma membrane-derived thylakoid membrane
N	0042651	cellular_component	thylakoid membrane
N	0048038	molecular_function	quinone binding
O	0005886	cellular_component	plasma membrane
O	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
O	0031676	cellular_component	plasma membrane-derived thylakoid membrane
O	0042651	cellular_component	thylakoid membrane
O	0048038	molecular_function	quinone binding
Q	0005615	cellular_component	extracellular space
S	0009767	biological_process	photosynthetic electron transport chain

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue DGD A 501

Chain	Residue
A	ASP6
A	VAL40
A	VAL43
A	ASN122
A	LEU123
A	LEU124
A	SER126
A	VAL266
C	TYR21
L	TYR20
L	THR52
A	LEU7
L	DGD401
A	GLN8
A	TRP29
A	LEU32
A	PRO33
A	LEU35
A	MET36
A	MET37

---

site_id	AC2
Number of Residues	11
Details	binding site for residue PGT C 201

Chain	Residue
A	LEU27
A	LEU138
C	SER17
C	GLY18
C	TYR19
C	GLU20
C	LEU26
G	LEU3
G	THR7
G	GLY48
G	LEU52

---

site_id	AC3
Number of Residues	13
Details	binding site for residue SQD D 601

Chain	Residue
D	PRO367
D	LEU371
D	PRO372
D	THR373
D	THR374
D	VAL448
D	LYS453
F	SER27
F	GLY29
F	ARG32
F	LEU125
F	LEU128
P	ARG357

---

site_id	AC4
Number of Residues	11
Details	binding site for residue PGT D 602

Chain	Residue
B	LEU416
B	TYR423
B	LYS430
D	GLN160
D	VAL163
D	ILE167
D	TYR168
D	PRO226
F	THR564
F	GLY565
F	LEU573

---

site_id	AC5
Number of Residues	19
Details	binding site for residue SQD F 701

Chain	Residue
D	ILE293
D	ASN359
D	VAL417
D	VAL424
D	ILE428
D	ASN431
D	ARG432
F	ARG174
F	ASP175
F	THR179
F	VAL182
F	LEU185
F	LEU240
F	LEU537
F	TYR538
F	ARG539
F	THR541
F	VAL542
F	VAL543

---

site_id	AC6
Number of Residues	10
Details	binding site for residue BCR F 702

Chain	Residue
F	GLU451
F	ILE457
F	THR461
F	VAL462
F	LEU466
F	HIS469
F	LEU473
F	PHE477
F	CLA704
P	MET184

---

site_id	AC7
Number of Residues	14
Details	binding site for residue SQD F 703

Chain	Residue
F	ILE303
F	ALA304
F	THR424
F	PHE425
F	PHE428
F	ARG432
F	LEU499
F	TRP506
F	TYR508
F	LYS515
F	PRO516
F	VAL517
F	GLN525
F	LEU528

---

site_id	AC8
Number of Residues	3
Details	binding site for residue CLA F 704

Chain	Residue
F	ILE472
F	BCR702
F	HIS469

---

site_id	AC9
Number of Residues	8
Details	binding site for residue SF4 I 201

Chain	Residue
I	CYS73
I	CYS103
I	ILE104
I	PHE105
I	CYS106
I	ALA107
I	ASN108
I	CYS109

---

site_id	AD1
Number of Residues	9
Details	binding site for residue SF4 I 202

Chain	Residue
I	CYS63
I	ILE64
I	ALA65
I	CYS66
I	GLU67
I	CYS69
I	CYS113
I	PRO114
I	CYS117

---

site_id	AD2
Number of Residues	11
Details	binding site for residue SF4 K 501

Chain	Residue
H	ARG69
K	ALA51
K	CYS52
K	CYS53
K	THR89
K	GLY115
K	ALA116
K	CYS117
K	MET123
K	CYS148
K	PRO149

---

site_id	AD3
Number of Residues	7
Details	binding site for residue SQD K 502

Chain	Residue
C	LEU43
C	LYS46
K	LEU31
K	ILE171
K	ASN172
K	ARG174
L	SQD402

---

site_id	AD4
Number of Residues	13
Details	binding site for residue SQD L 402

Chain	Residue
A	LEU74
K	ILE27
K	VAL34
K	TRP37
K	SQD502
L	PRO63
L	ILE65
L	ASN66
L	ARG68
N	LEU3
N	PHE29
N	ARG32
N	VAL138

---

site_id	AD5
Number of Residues	1
Details	binding site for residue ZN P 501

Chain	Residue
P	HIS130

---

site_id	AD6
Number of Residues	44
Details	binding site for Poly-Saccharide residues VAL A 43 through DGD L 401

Chain	Residue
A	ASP6
A	LEU7
A	ILE39
A	VAL40
A	ALA41
A	THR42
A	GLY44
A	VAL45
A	LEU46
A	VAL47
A	GLU52
A	LYS54
A	ILE55
A	ALA57
A	ALA58
A	GLN60
A	GLN121
A	ASN122
A	TRP280
A	GLN303
A	PHE306
A	ALA307
A	VAL308
A	TRP330
A	DGD501
L	ALA17
L	LEU19
L	TYR20
L	TYR31
L	ARG35
L	ALA39
L	SER40
L	SER41
L	PHE42
L	ARG44
L	ALA45
L	PHE46
L	MET47
L	PHE53
L	PHE54
L	PHE55
L	GLY57
L	LEU58
L	LEU60

---

site_id	AD7
Number of Residues	20
Details	binding site for Di-Saccharide DGD L 401 and PRO L 56

Chain	Residue
A	ASP6
A	LEU7
A	VAL43
A	GLN121
A	ASN122
A	TRP280
A	GLN303
A	PHE306
A	ALA307
A	VAL308
A	DGD501
L	ALA17
L	LEU19
L	TYR20
L	PHE53
L	PHE54
L	PHE55
L	GLY57
L	LEU58
L	LEU60

---

Functional Information from PROSITE/UniProt

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACEvCVrVCP

Chain	Residue	Details
I	CYS63-PRO74
I	CYS103-PRO114

---

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGmEKIaEnR

Chain	Residue	Details
H	LEU47-ARG58

---

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREsyDMFgivyegHpnlKrIL

Chain	Residue	Details
J	GLU121-LEU142

---

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GILApLaDGLKLIfKE

Chain	Residue	Details
A	GLY72-GLU87

---

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLPEAEeeLVa.G

Chain	Residue	Details
A	PRO231-GLY244

---

site_id	PS01036
Number of Residues	15
Details	HSP70_3 Heat shock hsp70 proteins family signature 3. YgLsGGhTQLPaIaQ

Chain	Residue	Details
B	TYR185-GLN199

---

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GvDKLIPVDVYlPgCPP

Chain	Residue	Details
K	GLY134-PRO150

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	160
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"HAMAP-Rule","id":"MF_01350","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	278
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"HAMAP-Rule","id":"MF_00445","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	100
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	29
Details	Domain: {"description":"4Fe-4S ferredoxin-type 1","evidences":[{"source":"HAMAP-Rule","id":"MF_01351","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	29
Details	Domain: {"description":"4Fe-4S ferredoxin-type 2","evidences":[{"source":"HAMAP-Rule","id":"MF_01351","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01351","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01356","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---