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6TJQ

Crystal Structure of Recombinant GBA in Complex with 2-Deoxy-2-fluoro-beta-D-glucopyranoside

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
BBB0004336molecular_functiongalactosylceramidase activity
BBB0004348molecular_functionglucosylceramidase activity
BBB0005102molecular_functionsignaling receptor binding
BBB0005124molecular_functionscavenger receptor binding
BBB0005515molecular_functionprotein binding
BBB0005615cellular_componentextracellular space
BBB0005764cellular_componentlysosome
BBB0005765cellular_componentlysosomal membrane
BBB0005783cellular_componentendoplasmic reticulum
BBB0005794cellular_componentGolgi apparatus
BBB0005802cellular_componenttrans-Golgi network
BBB0006665biological_processsphingolipid metabolic process
BBB0006678biological_processglucosylceramide metabolic process
BBB0006680biological_processglucosylceramide catabolic process
BBB0006914biological_processautophagy
BBB0007005biological_processmitochondrion organization
BBB0007040biological_processlysosome organization
BBB0007417biological_processcentral nervous system development
BBB0008203biological_processcholesterol metabolic process
BBB0008340biological_processdetermination of adult lifespan
BBB0008422molecular_functionbeta-glucosidase activity
BBB0009267biological_processcellular response to starvation
BBB0009268biological_processresponse to pH
BBB0014004biological_processmicroglia differentiation
BBB0016020cellular_componentmembrane
BBB0016241biological_processregulation of macroautophagy
BBB0016757molecular_functionglycosyltransferase activity
BBB0016787molecular_functionhydrolase activity
BBB0016798molecular_functionhydrolase activity, acting on glycosyl bonds
BBB0019882biological_processantigen processing and presentation
BBB0019915biological_processlipid storage
BBB0021694biological_processcerebellar Purkinje cell layer formation
BBB0021859biological_processpyramidal neuron differentiation
BBB0022904biological_processrespiratory electron transport chain
BBB0023021biological_processtermination of signal transduction
BBB0030259biological_processlipid glycosylation
BBB0031175biological_processneuron projection development
BBB0031333biological_processnegative regulation of protein-containing complex assembly
BBB0032006biological_processregulation of TOR signaling
BBB0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
BBB0032715biological_processnegative regulation of interleukin-6 production
BBB0033077biological_processT cell differentiation in thymus
BBB0033574biological_processresponse to testosterone
BBB0035307biological_processpositive regulation of protein dephosphorylation
BBB0042391biological_processregulation of membrane potential
BBB0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
BBB0043202cellular_componentlysosomal lumen
BBB0043243biological_processpositive regulation of protein-containing complex disassembly
BBB0043407biological_processnegative regulation of MAP kinase activity
BBB0043524biological_processnegative regulation of neuron apoptotic process
BBB0043627biological_processresponse to estrogen
BBB0046512biological_processsphingosine biosynthetic process
BBB0046513biological_processceramide biosynthetic process
BBB0046527molecular_functionglucosyltransferase activity
BBB0048469biological_processcell maturation
BBB0048854biological_processbrain morphogenesis
BBB0048872biological_processhomeostasis of number of cells
BBB0050295molecular_functionsteryl-beta-glucosidase activity
BBB0050728biological_processnegative regulation of inflammatory response
BBB0050877biological_processnervous system process
BBB0050905biological_processneuromuscular process
BBB0051246biological_processregulation of protein metabolic process
BBB0051248biological_processnegative regulation of protein metabolic process
BBB0051402biological_processneuron apoptotic process
BBB0061436biological_processestablishment of skin barrier
BBB0061518biological_processmicroglial cell proliferation
BBB0061744biological_processmotor behavior
BBB0070062cellular_componentextracellular exosome
BBB0071356biological_processcellular response to tumor necrosis factor
BBB0071425biological_processhematopoietic stem cell proliferation
BBB0071548biological_processresponse to dexamethasone
BBB0072676biological_processlymphocyte migration
BBB0097066biological_processresponse to thyroid hormone
BBB0098773biological_processskin epidermis development
BBB1901805biological_processbeta-glucoside catabolic process
BBB1903052biological_processpositive regulation of proteolysis involved in protein catabolic process
BBB1903061biological_processpositive regulation of protein lipidation
BBB1904457biological_processpositive regulation of neuronal action potential
BBB1904925biological_processpositive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
BBB1905037biological_processautophagosome organization
BBB1905165biological_processregulation of lysosomal protein catabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor => ECO:0000269|PubMed:15817452
ChainResidueDetails
BBBHIS255

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:15817452
ChainResidueDetails
BBBGLY360

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12792654, ECO:0000269|PubMed:17139081
ChainResidueDetails
BBBARG39

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:17139081, ECO:0000269|PubMed:19159218
ChainResidueDetails
BBBLYS79

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:17139081
ChainResidueDetails
BBBGLN166

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218
ChainResidueDetails
BBBHIS290

site_idSWS_FT_FI7
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BBBTHR482

Catalytic Information from CSA
site_idMCSA1
Number of Residues4
DetailsM-CSA 764
ChainResidueDetails
BBBHIS255activator, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor
BBBGLY360covalently attached, nucleofuge, nucleophile
BBBGLN362electrostatic stabiliser
BBBGLY390

221051

PDB entries from 2024-06-12

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