6TI3
Apo-SHMT from Streptococcus thermophilus Tyr55Ser variant in complex with D-Threonine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006544 | biological_process | glycine metabolic process |
| A | 0006545 | biological_process | glycine biosynthetic process |
| A | 0006563 | biological_process | L-serine metabolic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| A | 0046653 | biological_process | tetrahydrofolate metabolic process |
| B | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006544 | biological_process | glycine metabolic process |
| B | 0006545 | biological_process | glycine biosynthetic process |
| B | 0006563 | biological_process | L-serine metabolic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0046653 | biological_process | tetrahydrofolate metabolic process |
| C | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006544 | biological_process | glycine metabolic process |
| C | 0006545 | biological_process | glycine biosynthetic process |
| C | 0006563 | biological_process | L-serine metabolic process |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0035999 | biological_process | tetrahydrofolate interconversion |
| C | 0046653 | biological_process | tetrahydrofolate metabolic process |
| D | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006544 | biological_process | glycine metabolic process |
| D | 0006545 | biological_process | glycine biosynthetic process |
| D | 0006563 | biological_process | L-serine metabolic process |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0035999 | biological_process | tetrahydrofolate interconversion |
| D | 0046653 | biological_process | tetrahydrofolate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | TYR156 |
| A | ASP183 |
| A | HOH625 |
| A | HOH626 |
| A | HOH708 |
| A | HOH708 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue DTH A 502 |
| Chain | Residue |
| A | THR227 |
| A | HIS229 |
| A | LYS230 |
| A | HOH690 |
| A | HOH699 |
| C | GLU57 |
| C | GLY261 |
| C | GLY262 |
| C | HOH675 |
| C | HOH706 |
| A | SER97 |
| A | GLY98 |
| A | SER99 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 501 |
| Chain | Residue |
| B | LEU153 |
| B | ARG180 |
| B | HOH687 |
| B | HOH719 |
| C | ASP183 |
| C | HOH624 |
| C | HOH652 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue DTH C 502 |
| Chain | Residue |
| A | GLU57 |
| A | GLY261 |
| A | GLY262 |
| A | HOH737 |
| C | SER97 |
| C | GLY98 |
| C | SER99 |
| C | THR227 |
| C | HIS229 |
| C | LYS230 |
| C | HOH608 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 501 |
| Chain | Residue |
| B | TYR156 |
| B | ASP183 |
| B | HOH610 |
| B | HOH613 |
| B | HOH666 |
| B | HOH687 |
| B | HOH719 |
| B | HOH750 |
| C | ARG180 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue DTH B 502 |
| Chain | Residue |
| B | SER97 |
| B | GLY98 |
| B | SER99 |
| B | THR227 |
| B | HIS229 |
| B | LYS230 |
| B | HOH679 |
| B | HOH722 |
| D | GLU57 |
| D | GLY262 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue NA D 501 |
| Chain | Residue |
| D | ALA203 |
| D | ALA206 |
| D | HIS229 |
| D | LYS230 |
| D | THR231 |
| D | LEU232 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue DTH D 502 |
| Chain | Residue |
| B | GLU57 |
| B | GLY261 |
| B | GLY262 |
| B | HOH710 |
| D | SER97 |
| D | GLY98 |
| D | SER99 |
| D | HIS229 |
| D | LYS230 |
| D | HOH646 |
Functional Information from PROSITE/UniProt
| site_id | PS00096 |
| Number of Residues | 17 |
| Details | SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. HVtTTTTHKTLrGPRGG |
| Chain | Residue | Details |
| A | HIS222-GLY238 |
