6THQ
Crystal structure of branched-chain aminotransferase from thermophilic archaea Thermoproteus uzoniensis with norvaline
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004084 | molecular_function | branched-chain-amino-acid:2-oxoglutarate transaminase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009081 | biological_process | branched-chain amino acid metabolic process |
| A | 0009098 | biological_process | L-leucine biosynthetic process |
| A | 0009099 | biological_process | L-valine biosynthetic process |
| A | 0046394 | biological_process | carboxylic acid biosynthetic process |
| A | 0052654 | molecular_function | L-leucine:2-oxoglutarate transaminase activity |
| A | 0052655 | molecular_function | L-valine:2-oxoglutarate transaminase activity |
| A | 0052656 | molecular_function | L-isoleucine:2-oxoglutarate transaminase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004084 | molecular_function | branched-chain-amino-acid:2-oxoglutarate transaminase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009081 | biological_process | branched-chain amino acid metabolic process |
| B | 0009098 | biological_process | L-leucine biosynthetic process |
| B | 0009099 | biological_process | L-valine biosynthetic process |
| B | 0046394 | biological_process | carboxylic acid biosynthetic process |
| B | 0052654 | molecular_function | L-leucine:2-oxoglutarate transaminase activity |
| B | 0052655 | molecular_function | L-valine:2-oxoglutarate transaminase activity |
| B | 0052656 | molecular_function | L-isoleucine:2-oxoglutarate transaminase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004084 | molecular_function | branched-chain-amino-acid:2-oxoglutarate transaminase activity |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009081 | biological_process | branched-chain amino acid metabolic process |
| C | 0009098 | biological_process | L-leucine biosynthetic process |
| C | 0009099 | biological_process | L-valine biosynthetic process |
| C | 0046394 | biological_process | carboxylic acid biosynthetic process |
| C | 0052654 | molecular_function | L-leucine:2-oxoglutarate transaminase activity |
| C | 0052655 | molecular_function | L-valine:2-oxoglutarate transaminase activity |
| C | 0052656 | molecular_function | L-isoleucine:2-oxoglutarate transaminase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue PLP A 301 |
| Chain | Residue |
| A | HIS51 |
| A | ILE211 |
| A | THR212 |
| A | THR248 |
| A | PY5302 |
| A | HOH401 |
| A | HOH430 |
| A | ARG54 |
| A | ARG139 |
| A | LYS150 |
| A | TYR155 |
| A | GLU184 |
| A | SER186 |
| A | LEU208 |
| A | GLY210 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue PY5 A 302 |
| Chain | Residue |
| A | GLY33 |
| A | ARG54 |
| A | TYR91 |
| A | ARG139 |
| A | LYS150 |
| A | TYR155 |
| A | GLU184 |
| A | SER186 |
| A | GLY187 |
| A | GLU188 |
| A | ASN189 |
| A | GLY210 |
| A | ILE211 |
| A | THR212 |
| A | GLY247 |
| A | THR248 |
| A | ALA249 |
| A | PLP301 |
| A | HOH401 |
| A | HOH430 |
| A | HOH442 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue PLP B 301 |
| Chain | Residue |
| B | HIS51 |
| B | ARG54 |
| B | ARG139 |
| B | LYS150 |
| B | TYR155 |
| B | GLU184 |
| B | ASN189 |
| B | LEU208 |
| B | GLY210 |
| B | ILE211 |
| B | THR212 |
| B | GLY247 |
| B | THR248 |
| B | PY5302 |
| B | HOH407 |
| B | HOH429 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | binding site for residue PY5 B 302 |
| Chain | Residue |
| B | GLY33 |
| B | ARG54 |
| B | TYR91 |
| B | LYS150 |
| B | TYR155 |
| B | GLU184 |
| B | SER186 |
| B | GLY187 |
| B | GLU188 |
| B | GLY210 |
| B | ILE211 |
| B | THR212 |
| B | GLY247 |
| B | THR248 |
| B | ALA249 |
| B | PLP301 |
| B | HOH402 |
| B | HOH407 |
| B | HOH429 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | binding site for residue PY5 C 302 |
| Chain | Residue |
| B | ILE103 |
| C | ARG54 |
| C | TYR91 |
| C | ARG139 |
| C | LYS150 |
| C | TYR155 |
| C | GLU184 |
| C | SER186 |
| C | GLY187 |
| C | GLU188 |
| C | ASN189 |
| C | GLY210 |
| C | ILE211 |
| C | THR212 |
| C | GLY247 |
| C | THR248 |
| C | ALA249 |
| C | PLP301 |
| C | HOH408 |
| C | HOH413 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide PLP C 301 and LYS C 150 |
| Chain | Residue |
| C | TYR155 |
| C | GLU184 |
| C | GLU188 |
| C | ASN189 |
| C | LEU208 |
| C | GLY210 |
| C | ILE211 |
| C | THR212 |
| C | THR248 |
| C | PY5302 |
| C | HOH408 |
| C | HOH413 |
| C | VAL30 |
| C | PHE31 |
| C | HIS51 |
| C | ARG54 |
| C | SER58 |
| C | ARG139 |
| C | ALA149 |
| C | ALA151 |
Functional Information from PROSITE/UniProt
| site_id | PS00445 |
| Number of Residues | 21 |
| Details | FGGY_KINASES_2 FGGY family of carbohydrate kinases signature 2. AkIIGLdvpytae.ELSKAVVE |
| Chain | Residue | Details |
| A | ALA59-GLU79 |
| site_id | PS00770 |
| Number of Residues | 30 |
| Details | AA_TRANSFER_CLASS_4 Aminotransferases class-IV signature. EgSgeNIFivrrgv......LmTppledgi.LeGItR |
| Chain | Residue | Details |
| A | GLU184-ARG213 |
