Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6TD5

Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and bortezomib

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000502	cellular_component	proteasome complex
a	0005634	cellular_component	nucleus
a	0005737	cellular_component	cytoplasm
a	0005839	cellular_component	proteasome core complex
a	0006511	biological_process	ubiquitin-dependent protein catabolic process
a	0019773	cellular_component	proteasome core complex, alpha-subunit complex
a	0051603	biological_process	proteolysis involved in protein catabolic process
A	0000502	cellular_component	proteasome complex
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0051603	biological_process	proteolysis involved in protein catabolic process
b	0000502	cellular_component	proteasome complex
b	0005634	cellular_component	nucleus
b	0005737	cellular_component	cytoplasm
b	0005839	cellular_component	proteasome core complex
b	0006511	biological_process	ubiquitin-dependent protein catabolic process
b	0016787	molecular_function	hydrolase activity
b	0019773	cellular_component	proteasome core complex, alpha-subunit complex
b	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0016787	molecular_function	hydrolase activity
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0051603	biological_process	proteolysis involved in protein catabolic process
c	0000502	cellular_component	proteasome complex
c	0005634	cellular_component	nucleus
c	0005737	cellular_component	cytoplasm
c	0005839	cellular_component	proteasome core complex
c	0006511	biological_process	ubiquitin-dependent protein catabolic process
c	0019773	cellular_component	proteasome core complex, alpha-subunit complex
c	0051603	biological_process	proteolysis involved in protein catabolic process
C	0000502	cellular_component	proteasome complex
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0051603	biological_process	proteolysis involved in protein catabolic process
d	0005839	cellular_component	proteasome core complex
d	0006511	biological_process	ubiquitin-dependent protein catabolic process
d	0019773	cellular_component	proteasome core complex, alpha-subunit complex
d	0051603	biological_process	proteolysis involved in protein catabolic process
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0051603	biological_process	proteolysis involved in protein catabolic process
e	0000502	cellular_component	proteasome complex
e	0005634	cellular_component	nucleus
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0005839	cellular_component	proteasome core complex
e	0006511	biological_process	ubiquitin-dependent protein catabolic process
e	0016787	molecular_function	hydrolase activity
e	0019773	cellular_component	proteasome core complex, alpha-subunit complex
e	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
e	0051603	biological_process	proteolysis involved in protein catabolic process
E	0000502	cellular_component	proteasome complex
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0016787	molecular_function	hydrolase activity
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
f	0000502	cellular_component	proteasome complex
f	0005634	cellular_component	nucleus
f	0005737	cellular_component	cytoplasm
f	0005839	cellular_component	proteasome core complex
f	0006511	biological_process	ubiquitin-dependent protein catabolic process
f	0019773	cellular_component	proteasome core complex, alpha-subunit complex
f	0051603	biological_process	proteolysis involved in protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0051603	biological_process	proteolysis involved in protein catabolic process
g	0000502	cellular_component	proteasome complex
g	0005634	cellular_component	nucleus
g	0005737	cellular_component	cytoplasm
g	0005839	cellular_component	proteasome core complex
g	0006511	biological_process	ubiquitin-dependent protein catabolic process
g	0016787	molecular_function	hydrolase activity
g	0019773	cellular_component	proteasome core complex, alpha-subunit complex
g	0051603	biological_process	proteolysis involved in protein catabolic process
G	0000502	cellular_component	proteasome complex
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0016787	molecular_function	hydrolase activity
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0051603	biological_process	proteolysis involved in protein catabolic process
h	0004298	molecular_function	threonine-type endopeptidase activity
h	0005839	cellular_component	proteasome core complex
h	0051603	biological_process	proteolysis involved in protein catabolic process
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005839	cellular_component	proteasome core complex
H	0051603	biological_process	proteolysis involved in protein catabolic process
i	0004298	molecular_function	threonine-type endopeptidase activity
i	0005839	cellular_component	proteasome core complex
i	0051603	biological_process	proteolysis involved in protein catabolic process
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005839	cellular_component	proteasome core complex
I	0051603	biological_process	proteolysis involved in protein catabolic process
j	0000502	cellular_component	proteasome complex
j	0005634	cellular_component	nucleus
j	0005737	cellular_component	cytoplasm
j	0005839	cellular_component	proteasome core complex
j	0016787	molecular_function	hydrolase activity
j	0019774	cellular_component	proteasome core complex, beta-subunit complex
j	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
j	0051603	biological_process	proteolysis involved in protein catabolic process
J	0000502	cellular_component	proteasome complex
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005839	cellular_component	proteasome core complex
J	0016787	molecular_function	hydrolase activity
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
k	0005839	cellular_component	proteasome core complex
k	0010498	biological_process	proteasomal protein catabolic process
k	0051603	biological_process	proteolysis involved in protein catabolic process
K	0005839	cellular_component	proteasome core complex
K	0010498	biological_process	proteasomal protein catabolic process
K	0051603	biological_process	proteolysis involved in protein catabolic process
l	0004298	molecular_function	threonine-type endopeptidase activity
l	0005839	cellular_component	proteasome core complex
l	0051603	biological_process	proteolysis involved in protein catabolic process
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005839	cellular_component	proteasome core complex
L	0051603	biological_process	proteolysis involved in protein catabolic process
m	0000502	cellular_component	proteasome complex
m	0005634	cellular_component	nucleus
m	0005737	cellular_component	cytoplasm
m	0005839	cellular_component	proteasome core complex
m	0051603	biological_process	proteolysis involved in protein catabolic process
M	0000502	cellular_component	proteasome complex
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005839	cellular_component	proteasome core complex
M	0051603	biological_process	proteolysis involved in protein catabolic process
n	0000502	cellular_component	proteasome complex
n	0005634	cellular_component	nucleus
n	0005737	cellular_component	cytoplasm
n	0005839	cellular_component	proteasome core complex
n	0019774	cellular_component	proteasome core complex, beta-subunit complex
n	0051603	biological_process	proteolysis involved in protein catabolic process
N	0000502	cellular_component	proteasome complex
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005839	cellular_component	proteasome core complex
N	0019774	cellular_component	proteasome core complex, beta-subunit complex
N	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue BO2 H 301

Chain	Residue
H	THR55
H	THR74
H	SER75
H	SER76
H	ARG99
H	GLY101
H	ALA103
H	THR106
I	SER147

site_id	AC2
Number of Residues	10
Details	binding site for residue BO2 I 301

Chain	Residue
I	THR30
I	ASP46
I	ARG48
I	ALA49
I	THR50
I	GLU51
I	LYS62
I	GLY76
I	SER78
I	TYR197

site_id	AC3
Number of Residues	10
Details	binding site for residue BO2 L 401

Chain	Residue
L	THR100
L	ARG118
L	ALA119
L	SER120
L	THR121
L	LEU144
L	GLY146
L	ALA148
L	ALA268
L	N2E402

site_id	AC4
Number of Residues	14
Details	binding site for residue N2E L 402

Chain	Residue
K	PHE24
K	ILE29
L	SER120
L	GLY146
L	SER195
L	TYR212
L	PHE225
L	SER226
L	VAL227
L	GLY228
L	SER229
L	SER231
L	TYR235
L	BO2401

site_id	AC5
Number of Residues	12
Details	binding site for residue N2E l 402

Chain	Residue
k	PHE24
l	SER120
l	GLY146
l	SER195
l	TYR212
l	SER226
l	VAL227
l	GLY228
l	SER229
l	SER231
l	TYR235
l	BO2401

site_id	AC6
Number of Residues	16
Details	binding site for Di-peptide BO2 h 301 and THR h 55

Chain	Residue
h	THR56
h	ASP71
h	ARG73
h	THR74
h	SER75
h	SER76
h	LYS87
h	ARG99
h	GLY101
h	ALA103
h	THR106
h	GLY183
h	SER184
h	GLY185
h	SER224
i	SER147

site_id	AC7
Number of Residues	15
Details	binding site for Di-peptide BO2 i 301 and THR i 30

Chain	Residue
i	THR31
i	ASP46
i	ARG48
i	ALA49
i	THR50
i	GLU51
i	LYS62
i	GLY76
i	SER78
i	MET156
i	GLY157
i	SER158
i	GLY159
i	TYR197
i	SER198

site_id	AC8
Number of Residues	13
Details	binding site for Di-peptide BO2 l 401 and LEU l 144

Chain	Residue
l	THR100
l	ALA119
l	SER120
l	THR121
l	MET131
l	LYS132
l	THR143
l	ALA145
l	GLY146
l	ALA148
l	CYS151
l	N2E402
m	ASP251

site_id	AC9
Number of Residues	18
Details	binding site for Di-peptide BO2 l 401 and THR l 100

Chain	Residue
l	THR101
l	THR102
l	ASP116
l	ARG118
l	ALA119
l	SER120
l	THR121
l	LYS132
l	LEU144
l	GLY146
l	ALA148
l	GLY228
l	SER229
l	GLY230
l	ALA268
l	SER269
l	N2E402
m	ASP251

Functional Information from PROSITE/UniProt

site_id	PS00300
Number of Residues	14
Details	SRP54 SRP54-type proteins GTP-binding domain signature. PImFTSKSEyDrgV

Chain	Residue	Details
E	PRO99-VAL112

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdraiTvFSPdGHlfQVEYAqeA

Chain	Residue	Details
D	TYR3-ALA25
B	ALA4-ALA26
C	TYR5-ALA27
A	PHE6-ALA28
E	TYR108-ALA130
F	TYR170-ALA192

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. IAIkYkgGVLMAADtllsygslakwpnip.RirllgshsavcatGsyAD

Chain	Residue	Details
n	ILE8-ASP55
L	LEU103-ASP150
I	VAL33-ASP80
m	ALA137-ASP185
J	MET12-ASP59
H	LEU58-ASP105

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)