6TCN

Crystal structure of the omalizumab Fab - crystal form II

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 L 301

Chain	Residue
L	LYS43
L	LYS46
L	LYS49
L	EDO302
L	HOH449

---

site_id	AC2
Number of Residues	7
Details	binding site for residue EDO L 302

Chain	Residue
L	GLU85
L	ASP86
L	SO4301
L	GLN41
L	LYS43
L	LYS49
L	ARG65

---

site_id	AC3
Number of Residues	2
Details	binding site for residue EDO L 303

Chain	Residue
L	PRO8
L	SER9

---

site_id	AC4
Number of Residues	3
Details	binding site for residue EDO L 304

Chain	Residue
L	PRO63
L	ARG65
L	GLU85

---

site_id	AC5
Number of Residues	1
Details	binding site for residue EDO L 305

Chain	Residue
L	SER64

---

site_id	AC6
Number of Residues	5
Details	binding site for residue SO4 H 301

Chain	Residue
H	ARG98
H	SER100
H	HIS101
H	TYR102
H	HOH407

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO H 302

Chain	Residue
H	LEU149
H	VAL177
H	SER185
H	SER187
H	HOH410
L	THR182
L	HOH401

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO H 303

Chain	Residue
H	SER7
H	GLY8
H	GLY9
H	THR115
H	PEG305

---

site_id	AC9
Number of Residues	2
Details	binding site for residue EDO H 304

Chain	Residue
H	ARG87
H	ALA88

---

site_id	AD1
Number of Residues	5
Details	binding site for residue PEG H 305

Chain	Residue
H	GLY114
H	THR115
H	LEU116
H	PRO157
H	EDO303

---

site_id	AD2
Number of Residues	2
Details	binding site for residue EDO A 301

Chain	Residue
A	SER80
L	THR5

---

site_id	AD3
Number of Residues	2
Details	binding site for residue TRS A 302

Chain	Residue
A	LYS194
A	ARG215

---

site_id	AD4
Number of Residues	4
Details	binding site for residue SO4 B 301

Chain	Residue
B	ARG98
B	SER100
B	HIS101
B	TYR102

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR196-HIS202
H	TYR202-HIS208

---