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6TA1

Fatty acid synthase of S. cerevisiae

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0003824molecular_functioncatalytic activity
A0004312molecular_functionfatty acid synthase activity
A0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
A0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A0004321molecular_functionfatty-acyl-CoA synthase activity
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005835cellular_componentfatty acid synthase complex
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0006633biological_processfatty acid biosynthetic process
A0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
A0016491molecular_functionoxidoreductase activity
A0016740molecular_functiontransferase activity
A0016746molecular_functionacyltransferase activity
A0042759biological_processlong-chain fatty acid biosynthetic process
A0046872molecular_functionmetal ion binding
B0000287molecular_functionmagnesium ion binding
B0003824molecular_functioncatalytic activity
B0004312molecular_functionfatty acid synthase activity
B0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
B0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B0004321molecular_functionfatty-acyl-CoA synthase activity
B0005515molecular_functionprotein binding
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005835cellular_componentfatty acid synthase complex
B0006629biological_processlipid metabolic process
B0006631biological_processfatty acid metabolic process
B0006633biological_processfatty acid biosynthetic process
B0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
B0016491molecular_functionoxidoreductase activity
B0016740molecular_functiontransferase activity
B0016746molecular_functionacyltransferase activity
B0042759biological_processlong-chain fatty acid biosynthetic process
B0046872molecular_functionmetal ion binding
C0003824molecular_functioncatalytic activity
C0004312molecular_functionfatty acid synthase activity
C0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
C0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
C0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
C0004321molecular_functionfatty-acyl-CoA synthase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005811cellular_componentlipid droplet
C0005829cellular_componentcytosol
C0005835cellular_componentfatty acid synthase complex
C0006629biological_processlipid metabolic process
C0006631biological_processfatty acid metabolic process
C0006633biological_processfatty acid biosynthetic process
C0016297molecular_functionfatty acyl-[ACP] hydrolase activity
C0016409molecular_functionpalmitoyltransferase activity
C0016491molecular_functionoxidoreductase activity
C0016740molecular_functiontransferase activity
C0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
C0016787molecular_functionhydrolase activity
C0016829molecular_functionlyase activity
C0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
C0042759biological_processlong-chain fatty acid biosynthetic process
C0141148molecular_functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
D0000287molecular_functionmagnesium ion binding
D0003824molecular_functioncatalytic activity
D0004312molecular_functionfatty acid synthase activity
D0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
D0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
D0004321molecular_functionfatty-acyl-CoA synthase activity
D0005515molecular_functionprotein binding
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0005835cellular_componentfatty acid synthase complex
D0006629biological_processlipid metabolic process
D0006631biological_processfatty acid metabolic process
D0006633biological_processfatty acid biosynthetic process
D0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
D0016491molecular_functionoxidoreductase activity
D0016740molecular_functiontransferase activity
D0016746molecular_functionacyltransferase activity
D0042759biological_processlong-chain fatty acid biosynthetic process
D0046872molecular_functionmetal ion binding
E0003824molecular_functioncatalytic activity
E0004312molecular_functionfatty acid synthase activity
E0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
E0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
E0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
E0004321molecular_functionfatty-acyl-CoA synthase activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005811cellular_componentlipid droplet
E0005829cellular_componentcytosol
E0005835cellular_componentfatty acid synthase complex
E0006629biological_processlipid metabolic process
E0006631biological_processfatty acid metabolic process
E0006633biological_processfatty acid biosynthetic process
E0016297molecular_functionfatty acyl-[ACP] hydrolase activity
E0016409molecular_functionpalmitoyltransferase activity
E0016491molecular_functionoxidoreductase activity
E0016740molecular_functiontransferase activity
E0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
E0016787molecular_functionhydrolase activity
E0016829molecular_functionlyase activity
E0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
E0042759biological_processlong-chain fatty acid biosynthetic process
E0141148molecular_functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
F0000287molecular_functionmagnesium ion binding
F0003824molecular_functioncatalytic activity
F0004312molecular_functionfatty acid synthase activity
F0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
F0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
F0004321molecular_functionfatty-acyl-CoA synthase activity
F0005515molecular_functionprotein binding
F0005739cellular_componentmitochondrion
F0005829cellular_componentcytosol
F0005835cellular_componentfatty acid synthase complex
F0006629biological_processlipid metabolic process
F0006631biological_processfatty acid metabolic process
F0006633biological_processfatty acid biosynthetic process
F0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
F0016491molecular_functionoxidoreductase activity
F0016740molecular_functiontransferase activity
F0016746molecular_functionacyltransferase activity
F0042759biological_processlong-chain fatty acid biosynthetic process
F0046872molecular_functionmetal ion binding
G0003824molecular_functioncatalytic activity
G0004312molecular_functionfatty acid synthase activity
G0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
G0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
G0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
G0004321molecular_functionfatty-acyl-CoA synthase activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005811cellular_componentlipid droplet
G0005829cellular_componentcytosol
G0005835cellular_componentfatty acid synthase complex
G0006629biological_processlipid metabolic process
G0006631biological_processfatty acid metabolic process
G0006633biological_processfatty acid biosynthetic process
G0016297molecular_functionfatty acyl-[ACP] hydrolase activity
G0016409molecular_functionpalmitoyltransferase activity
G0016491molecular_functionoxidoreductase activity
G0016740molecular_functiontransferase activity
G0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
G0016787molecular_functionhydrolase activity
G0016829molecular_functionlyase activity
G0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
G0042759biological_processlong-chain fatty acid biosynthetic process
G0141148molecular_functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
H0003824molecular_functioncatalytic activity
H0004312molecular_functionfatty acid synthase activity
H0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
H0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
H0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
H0004321molecular_functionfatty-acyl-CoA synthase activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005811cellular_componentlipid droplet
H0005829cellular_componentcytosol
H0005835cellular_componentfatty acid synthase complex
H0006629biological_processlipid metabolic process
H0006631biological_processfatty acid metabolic process
H0006633biological_processfatty acid biosynthetic process
H0016297molecular_functionfatty acyl-[ACP] hydrolase activity
H0016409molecular_functionpalmitoyltransferase activity
H0016491molecular_functionoxidoreductase activity
H0016740molecular_functiontransferase activity
H0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
H0016787molecular_functionhydrolase activity
H0016829molecular_functionlyase activity
H0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
H0042759biological_processlong-chain fatty acid biosynthetic process
H0141148molecular_functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
I0000287molecular_functionmagnesium ion binding
I0003824molecular_functioncatalytic activity
I0004312molecular_functionfatty acid synthase activity
I0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
I0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
I0004321molecular_functionfatty-acyl-CoA synthase activity
I0005515molecular_functionprotein binding
I0005739cellular_componentmitochondrion
I0005829cellular_componentcytosol
I0005835cellular_componentfatty acid synthase complex
I0006629biological_processlipid metabolic process
I0006631biological_processfatty acid metabolic process
I0006633biological_processfatty acid biosynthetic process
I0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
I0016491molecular_functionoxidoreductase activity
I0016740molecular_functiontransferase activity
I0016746molecular_functionacyltransferase activity
I0042759biological_processlong-chain fatty acid biosynthetic process
I0046872molecular_functionmetal ion binding
J0003824molecular_functioncatalytic activity
J0004312molecular_functionfatty acid synthase activity
J0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
J0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
J0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
J0004321molecular_functionfatty-acyl-CoA synthase activity
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005811cellular_componentlipid droplet
J0005829cellular_componentcytosol
J0005835cellular_componentfatty acid synthase complex
J0006629biological_processlipid metabolic process
J0006631biological_processfatty acid metabolic process
J0006633biological_processfatty acid biosynthetic process
J0016297molecular_functionfatty acyl-[ACP] hydrolase activity
J0016409molecular_functionpalmitoyltransferase activity
J0016491molecular_functionoxidoreductase activity
J0016740molecular_functiontransferase activity
J0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
J0016787molecular_functionhydrolase activity
J0016829molecular_functionlyase activity
J0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
J0042759biological_processlong-chain fatty acid biosynthetic process
J0141148molecular_functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
K0000287molecular_functionmagnesium ion binding
K0003824molecular_functioncatalytic activity
K0004312molecular_functionfatty acid synthase activity
K0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
K0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
K0004321molecular_functionfatty-acyl-CoA synthase activity
K0005515molecular_functionprotein binding
K0005739cellular_componentmitochondrion
K0005829cellular_componentcytosol
K0005835cellular_componentfatty acid synthase complex
K0006629biological_processlipid metabolic process
K0006631biological_processfatty acid metabolic process
K0006633biological_processfatty acid biosynthetic process
K0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
K0016491molecular_functionoxidoreductase activity
K0016740molecular_functiontransferase activity
K0016746molecular_functionacyltransferase activity
K0042759biological_processlong-chain fatty acid biosynthetic process
K0046872molecular_functionmetal ion binding
L0003824molecular_functioncatalytic activity
L0004312molecular_functionfatty acid synthase activity
L0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
L0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
L0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
L0004321molecular_functionfatty-acyl-CoA synthase activity
L0005515molecular_functionprotein binding
L0005737cellular_componentcytoplasm
L0005739cellular_componentmitochondrion
L0005811cellular_componentlipid droplet
L0005829cellular_componentcytosol
L0005835cellular_componentfatty acid synthase complex
L0006629biological_processlipid metabolic process
L0006631biological_processfatty acid metabolic process
L0006633biological_processfatty acid biosynthetic process
L0016297molecular_functionfatty acyl-[ACP] hydrolase activity
L0016409molecular_functionpalmitoyltransferase activity
L0016491molecular_functionoxidoreductase activity
L0016740molecular_functiontransferase activity
L0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
L0016787molecular_functionhydrolase activity
L0016829molecular_functionlyase activity
L0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
L0042759biological_processlong-chain fatty acid biosynthetic process
L0141148molecular_functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
Functional Information from PDB Data
site_idAC1
Number of Residues22
Detailsbinding site for residue NDP A 2001
ChainResidue
AGLY682
AALA773
AILE774
AILE794
APRO825
AMET826
ATYR839
ALYS843
AILE869
AGLY870
ATHR875
ASER687
AGLY876
ALEU877
AMET878
AILE688
ASER708
AARG709
AASN738
AGLN739
APHE771
AALA772

site_idAC2
Number of Residues19
Detailsbinding site for residue FMN G 2101
ChainResidue
GPRO595
GGLY596
GMET597
GTHR598
GCYS600
GASN650
GLYS706
GTHR733
GARG736
GGLY737
GGLY738
GGLY739
GSER769
GGLY770
GPHE771
GGLY802
GSER803
GLEU1054
GALA1059

site_idAC3
Number of Residues22
Detailsbinding site for residue NDP B 2001
ChainResidue
BGLY682
BSER687
BILE688
BSER708
BARG709
BASN738
BGLN739
BPHE771
BALA772
BALA773
BILE774
BILE794
BPRO825
BMET826
BTYR839
BLYS843
BILE869
BGLY870
BTHR875
BGLY876
BLEU877
BMET878

site_idAC4
Number of Residues19
Detailsbinding site for residue FMN C 2101
ChainResidue
CPRO595
CGLY596
CMET597
CTHR598
CCYS600
CASN650
CLYS706
CTHR733
CARG736
CGLY737
CGLY738
CGLY739
CSER769
CGLY770
CPHE771
CGLY802
CSER803
CLEU1054
CALA1059

site_idAC5
Number of Residues22
Detailsbinding site for residue NDP D 2001
ChainResidue
DGLY870
DTHR875
DGLY876
DLEU877
DMET878
DGLY682
DSER687
DILE688
DSER708
DARG709
DASN738
DGLN739
DPHE771
DALA772
DALA773
DILE774
DILE794
DPRO825
DMET826
DTYR839
DLYS843
DILE869

site_idAC6
Number of Residues19
Detailsbinding site for residue FMN E 2101
ChainResidue
EPRO595
EGLY596
EMET597
ETHR598
ECYS600
EASN650
ELYS706
ETHR733
EARG736
EGLY737
EGLY738
EGLY739
ESER769
EGLY770
EPHE771
EGLY802
ESER803
ELEU1054
EALA1059

site_idAC7
Number of Residues22
Detailsbinding site for residue NDP K 2001
ChainResidue
KGLY682
KSER687
KILE688
KSER708
KARG709
KASN738
KGLN739
KPHE771
KALA772
KALA773
KILE774
KILE794
KPRO825
KMET826
KTYR839
KLYS843
KILE869
KGLY870
KTHR875
KGLY876
KLEU877
KMET878

site_idAC8
Number of Residues19
Detailsbinding site for residue FMN L 2101
ChainResidue
LPRO595
LGLY596
LMET597
LTHR598
LCYS600
LASN650
LLYS706
LTHR733
LARG736
LGLY737
LGLY738
LGLY739
LSER769
LGLY770
LPHE771
LGLY802
LSER803
LLEU1054
LALA1059

site_idAC9
Number of Residues22
Detailsbinding site for residue NDP F 2001
ChainResidue
FGLY682
FSER687
FILE688
FSER708
FARG709
FASN738
FGLN739
FPHE771
FALA772
FALA773
FILE774
FILE794
FPRO825
FMET826
FTYR839
FLYS843
FILE869
FGLY870
FTHR875
FGLY876
FLEU877
FMET878

site_idAD1
Number of Residues19
Detailsbinding site for residue FMN H 2101
ChainResidue
HPRO595
HGLY596
HMET597
HTHR598
HCYS600
HASN650
HLYS706
HTHR733
HARG736
HGLY737
HGLY738
HGLY739
HSER769
HGLY770
HPHE771
HGLY802
HSER803
HLEU1054
HALA1059

site_idAD2
Number of Residues22
Detailsbinding site for residue NDP I 2001
ChainResidue
IGLY682
ISER687
IILE688
ISER708
IARG709
IASN738
IGLN739
IPHE771
IALA772
IALA773
IILE774
IILE794
IPRO825
IMET826
ITYR839
ILYS843
IILE869
IGLY870
ITHR875
IGLY876
ILEU877
IMET878

site_idAD3
Number of Residues19
Detailsbinding site for residue FMN J 2101
ChainResidue
JPRO595
JGLY596
JMET597
JTHR598
JCYS600
JASN650
JLYS706
JTHR733
JARG736
JGLY737
JGLY738
JGLY739
JSER769
JGLY770
JPHE771
JGLY802
JSER803
JLEU1054
JALA1059

Functional Information from PROSITE/UniProt
site_idPS00012
Number of Residues16
DetailsPHOSPHOPANTETHEINE Phosphopantetheine attachment site. LVGGKSTVQNEILGDL
ChainResidueDetails
ALEU175-LEU190

site_idPS00606
Number of Residues17
DetailsKS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATSveSV
ChainResidueDetails
AGLY1296-VAL1312

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues450
DetailsDomain: {"description":"Carrier","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1194
DetailsRegion: {"description":"Beta-ketoacyl reductase"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues18
DetailsActive site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues132
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19679086","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15665377","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues6
DetailsModified residue: {"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17431182","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues12
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues24
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues750
DetailsDomain: {"description":"MaoC-like"}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues2328
DetailsRegion: {"description":"Enoyl reductase"}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues2892
DetailsRegion: {"description":"Dehydratase"}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues1308
DetailsRegion: {"description":"Malonyl/palmitoyl transferase"}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues6
DetailsActive site: {"description":"For acetyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues6
DetailsActive site: {"description":"For malonyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues6
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

249697

PDB entries from 2026-02-25

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