6T5X
Crystal structure of Salmonella typhimurium FabG in complex with NADPH at 1.5 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0030497 | biological_process | fatty acid elongation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0030497 | biological_process | fatty acid elongation |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 35 |
| Details | binding site for residue NDP A 301 |
| Chain | Residue |
| A | GLY12 |
| A | ALA87 |
| A | GLY88 |
| A | ILE89 |
| A | ILE136 |
| A | GLY137 |
| A | SER138 |
| A | TYR151 |
| A | LYS155 |
| A | PRO181 |
| A | GLY182 |
| A | SER14 |
| A | ILE184 |
| A | THR186 |
| A | MET188 |
| A | THR189 |
| A | HOH404 |
| A | HOH405 |
| A | HOH409 |
| A | HOH423 |
| A | HOH427 |
| A | HOH429 |
| A | ARG15 |
| A | HOH434 |
| A | HOH450 |
| A | HOH453 |
| A | HOH454 |
| A | HOH463 |
| A | HOH491 |
| A | ILE17 |
| A | THR37 |
| A | LEU58 |
| A | ASN59 |
| A | VAL60 |
| A | ASN86 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 302 |
| Chain | Residue |
| A | GLU233 |
| A | THR234 |
| A | HOH452 |
| B | GLU233 |
| B | THR234 |
| B | HOH532 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | ARG91 |
| A | HOH409 |
| A | HOH423 |
| A | HOH428 |
| A | HOH542 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 304 |
| Chain | Residue |
| A | SER2 |
| A | ASP225 |
| A | GLU226 |
| A | HOH403 |
| A | HOH433 |
| site_id | AC5 |
| Number of Residues | 33 |
| Details | binding site for residue NDP B 301 |
| Chain | Residue |
| B | GLY12 |
| B | SER14 |
| B | ARG15 |
| B | ALA36 |
| B | THR37 |
| B | LEU58 |
| B | ASN59 |
| B | VAL60 |
| B | ASN86 |
| B | ALA87 |
| B | GLY88 |
| B | ILE89 |
| B | ILE136 |
| B | GLY137 |
| B | TYR151 |
| B | LYS155 |
| B | PRO181 |
| B | GLY182 |
| B | ILE184 |
| B | THR186 |
| B | HOH407 |
| B | HOH413 |
| B | HOH429 |
| B | HOH436 |
| B | HOH443 |
| B | HOH444 |
| B | HOH465 |
| B | HOH470 |
| B | HOH492 |
| B | HOH510 |
| B | HOH536 |
| B | HOH543 |
| B | HOH580 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 302 |
| Chain | Residue |
| B | ILE89 |
| B | ARG91 |
| B | ARG123 |
| B | HOH405 |
| B | HOH409 |
| B | HOH444 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvvgtmgnagQanYAAAKAGLiGFSkSLA |
| Chain | Residue | Details |
| A | SER138-ALA166 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10001","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 34 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
