6T5B
KRasG12C ligand complex
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 201 |
| Chain | Residue |
| A | SER17 |
| A | GDP202 |
| A | HOH324 |
| A | HOH344 |
| A | HOH353 |
| A | HOH358 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | binding site for residue GDP A 202 |
| Chain | Residue |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | ASP30 |
| A | GLU31 |
| A | TYR32 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | LEU120 |
| A | SER145 |
| A | ALA146 |
| A | LYS147 |
| A | MG201 |
| A | HOH318 |
| A | HOH324 |
| A | HOH339 |
| A | HOH344 |
| A | HOH353 |
| A | HOH364 |
| A | HOH421 |
| A | GLY13 |
| A | VAL14 |
| A | GLY15 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | binding site for residue O7K A 203 |
| Chain | Residue |
| A | GLY10 |
| A | CYS12 |
| A | LYS16 |
| A | PRO34 |
| A | THR58 |
| A | ALA59 |
| A | GLY60 |
| A | GLN61 |
| A | GLU62 |
| A | GLU63 |
| A | TYR64 |
| A | ARG68 |
| A | ASP69 |
| A | MET72 |
| A | HIS95 |
| A | TYR96 |
| A | GLN99 |
| A | VAL103 |
| A | HOH377 |
| A | HOH387 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 204 |
| Chain | Residue |
| A | ASN85 |
| A | ASN86 |
| A | THR87 |
| A | THR124 |
| A | HOH315 |
| A | HOH317 |
| A | HOH348 |
| A | HOH375 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylmethionine; in GTPase KRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
