6T50

ROR(gamma)t ligand binding domain in complex with 25-hydroxycholesterol and allosteric ligand Glenmark

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue HC3 A 601

Chain	Residue
A	GLN286
A	LEU324
A	MET365
A	LEU396
A	HIS479
A	LEU483
A	GOL603
A	HOH723

---

site_id	AC2
Number of Residues	12
Details	binding site for residue MJE A 602

Chain	Residue
A	LEU324
A	THR325
A	ILE328
A	GLN329
A	LYS354
A	LEU483
A	GLN484
A	ALA496
A	ALA497
A	PHE498
A	LEU505
A	ALA321

---

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL A 603

Chain	Residue
A	HIS323
A	PHE377
A	PHE378
A	GLU379
A	HC3601

---