6T4V
Crystal structure of 2-methylisocitrate lyase (PrpB) from Pseudomonas aeruginosa in apo form.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0019629 | biological_process | obsolete propionate catabolic process, 2-methylcitrate cycle |
| A | 0046421 | molecular_function | methylisocitrate lyase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0019629 | biological_process | obsolete propionate catabolic process, 2-methylcitrate cycle |
| B | 0046421 | molecular_function | methylisocitrate lyase activity |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0019629 | biological_process | obsolete propionate catabolic process, 2-methylcitrate cycle |
| C | 0046421 | molecular_function | methylisocitrate lyase activity |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0019629 | biological_process | obsolete propionate catabolic process, 2-methylcitrate cycle |
| D | 0046421 | molecular_function | methylisocitrate lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue PYR C 301 |
| Chain | Residue |
| C | LEU66 |
| C | PHE92 |
| C | ASN98 |
| C | ARG101 |
| C | THR102 |
| D | ILE63 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue PYR A 301 |
| Chain | Residue |
| A | ARG101 |
| A | THR102 |
| B | ILE63 |
| A | LEU66 |
| A | PHE92 |
| A | ASN98 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue PYR B 301 |
| Chain | Residue |
| A | ILE63 |
| B | PHE92 |
| B | ASN98 |
| B | ARG101 |
| B | THR102 |
| B | HOH486 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue PYR D 301 |
| Chain | Residue |
| C | ILE63 |
| D | PHE92 |
| D | ASN98 |
| D | ARG101 |
| D | THR102 |
| D | HOH455 |
Functional Information from PROSITE/UniProt
| site_id | PS00161 |
| Number of Residues | 6 |
| Details | ISOCITRATE_LYASE Isocitrate lyase signature. KRCGHR |
| Chain | Residue | Details |
| C | LYS123-ARG128 |
