6T3T

Structure of the 4-hydroxy-tetrahydrodipicolinate synthase from the thermoacidophilic methanotroph Methylacidiphilum fumariolicum SolV

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
A	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
A	0009085	biological_process	lysine biosynthetic process
A	0009089	biological_process	lysine biosynthetic process via diaminopimelate
A	0009436	biological_process	glyoxylate catabolic process
A	0016829	molecular_function	lyase activity
A	0019877	biological_process	diaminopimelate biosynthetic process
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
B	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
B	0009085	biological_process	lysine biosynthetic process
B	0009089	biological_process	lysine biosynthetic process via diaminopimelate
B	0009436	biological_process	glyoxylate catabolic process
B	0016829	molecular_function	lyase activity
B	0019877	biological_process	diaminopimelate biosynthetic process
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
C	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
C	0009085	biological_process	lysine biosynthetic process
C	0009089	biological_process	lysine biosynthetic process via diaminopimelate
C	0009436	biological_process	glyoxylate catabolic process
C	0016829	molecular_function	lyase activity
C	0019877	biological_process	diaminopimelate biosynthetic process
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
D	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
D	0009085	biological_process	lysine biosynthetic process
D	0009089	biological_process	lysine biosynthetic process via diaminopimelate
D	0009436	biological_process	glyoxylate catabolic process
D	0016829	molecular_function	lyase activity
D	0019877	biological_process	diaminopimelate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 B 401

Chain	Residue
B	ALA9
B	GLY43
B	THR44
B	THR45
B	LEU101
B	TYR133
B	LYS162

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site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 401

Chain	Residue
A	THR44
A	THR45
A	TYR133
A	LYS162
A	ALA9
A	GLY43

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site_id	AC3
Number of Residues	8
Details	binding site for residue SO4 C 401

Chain	Residue
C	ALA9
C	GLY43
C	THR44
C	THR45
C	TYR133
C	LYS162
C	HOH510
C	HOH609

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site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 D 401

Chain	Residue
D	GLY43
D	THR44
D	THR45
D	TYR133
D	LYS162

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Functional Information from PROSITE/UniProt

site_id	PS00665
Number of Residues	18
Details	DHDPS_1 Dihydrodipicolinate synthase signature 1. GIVpvGTTGESptlsyeE

Chain	Residue	Details
B	GLY38-GLU55

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