6T36

Crystal structure of the PTPN3 PDZ domain bound to the HBV core protein C-terminal peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000165	biological_process	MAPK cascade
A	0001784	molecular_function	phosphotyrosine residue binding
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0006470	biological_process	protein dephosphorylation
A	0008092	molecular_function	cytoskeletal protein binding
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0016020	cellular_component	membrane
A	0016311	biological_process	dephosphorylation
A	0016787	molecular_function	hydrolase activity
A	0017080	molecular_function	sodium channel regulator activity
A	0042059	biological_process	negative regulation of epidermal growth factor receptor signaling pathway
A	0045930	biological_process	negative regulation of mitotic cell cycle
A	0051045	biological_process	negative regulation of membrane protein ectodomain proteolysis
A	0051117	molecular_function	ATPase binding
A	0098902	biological_process	regulation of membrane depolarization during action potential
A	1902305	biological_process	regulation of sodium ion transmembrane transport
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0005198	molecular_function	structural molecule activity
B	0005576	cellular_component	extracellular region
B	0019028	cellular_component	viral capsid
B	0030430	cellular_component	host cell cytoplasm
B	0039619	cellular_component	T=4 icosahedral viral capsid
B	0043657	cellular_component	host cell
B	0044423	cellular_component	virion component
B	0046718	biological_process	symbiont entry into host cell
B	0075521	biological_process	microtubule-dependent intracellular transport of viral material towards nucleus
B	0075606	biological_process	transport of viral material towards nucleus
B	0075732	biological_process	viral penetration into host nucleus

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue BR A 1001

Chain	Residue
A	LYS552

---

Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRTG

Chain	Residue	Details
A	VAL840-GLY850

---

site_id	PS00660
Number of Residues	30
Details	FERM_1 FERM domain signature 1. WLeasKaIrkQ..Lkggfpct.LhfrvrFFipD

Chain	Residue	Details
A	TRP84-ASP113

---

site_id	PS00661
Number of Residues	30
Details	FERM_2 FERM domain signature 2. HeqhsglkqsEAescYIni.ArtLdfYGvEL

Chain	Residue	Details
A	HIS192-LEU221

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Domain: {"description":"PDZ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00143","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---