6T1T
Cytochrome P450 reductase in complex with NADPH from Candida tropicalis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003958 | molecular_function | NADPH-hemoprotein reductase activity |
| A | 0003959 | molecular_function | NADPH dehydrogenase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006694 | biological_process | steroid biosynthetic process |
| A | 0006696 | biological_process | ergosterol biosynthetic process |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0010181 | molecular_function | FMN binding |
| A | 0016126 | biological_process | sterol biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0050661 | molecular_function | NADP binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003958 | molecular_function | NADPH-hemoprotein reductase activity |
| B | 0003959 | molecular_function | NADPH dehydrogenase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005741 | cellular_component | mitochondrial outer membrane |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006694 | biological_process | steroid biosynthetic process |
| B | 0006696 | biological_process | ergosterol biosynthetic process |
| B | 0008202 | biological_process | steroid metabolic process |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0010181 | molecular_function | FMN binding |
| B | 0016126 | biological_process | sterol biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 31 |
| Details | binding site for residue FAD A 700 |
| Chain | Residue |
| A | HIS303 |
| A | SER441 |
| A | THR456 |
| A | ALA457 |
| A | VAL458 |
| A | GLU460 |
| A | VAL470 |
| A | THR471 |
| A | GLY472 |
| A | VAL473 |
| A | VAL474 |
| A | GLY363 |
| A | THR475 |
| A | TRP679 |
| A | FMN701 |
| A | HOH806 |
| A | HOH817 |
| A | HOH825 |
| A | HOH836 |
| A | HOH889 |
| A | HOH900 |
| A | HOH908 |
| A | PRO364 |
| A | HOH930 |
| A | HOH935 |
| A | LYS404 |
| A | PHE405 |
| A | ASN406 |
| A | ARG438 |
| A | TYR439 |
| A | TYR440 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | binding site for residue FMN A 701 |
| Chain | Residue |
| A | SER65 |
| A | GLN66 |
| A | THR67 |
| A | GLY68 |
| A | THR69 |
| A | ALA70 |
| A | ALA116 |
| A | THR117 |
| A | TYR118 |
| A | GLY119 |
| A | GLY121 |
| A | LEU151 |
| A | GLY152 |
| A | ASN153 |
| A | TYR156 |
| A | PHE158 |
| A | PHE159 |
| A | ASN160 |
| A | ASP186 |
| A | LEU191 |
| A | VAL678 |
| A | FAD700 |
| A | HOH857 |
| A | HOH918 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue NDP A 702 |
| Chain | Residue |
| A | ARG282 |
| A | GLY535 |
| A | THR536 |
| A | CYS567 |
| A | ARG568 |
| A | SER598 |
| A | ARG599 |
| A | LYS605 |
| A | TYR607 |
| A | GLN609 |
| A | ARG637 |
| A | MET638 |
| A | ASP641 |
| A | HOH906 |
| A | HOH962 |
| site_id | AC4 |
| Number of Residues | 32 |
| Details | binding site for residue FAD B 700 |
| Chain | Residue |
| B | HOH943 |
| B | HOH946 |
| B | HOH965 |
| B | HIS303 |
| B | GLY363 |
| B | PRO364 |
| B | LYS404 |
| B | PHE405 |
| B | ASN406 |
| B | ARG438 |
| B | TYR439 |
| B | TYR440 |
| B | SER441 |
| B | THR456 |
| B | ALA457 |
| B | VAL458 |
| B | GLU460 |
| B | VAL470 |
| B | THR471 |
| B | GLY472 |
| B | VAL473 |
| B | VAL474 |
| B | THR475 |
| B | TRP679 |
| B | FMN701 |
| B | HOH803 |
| B | HOH821 |
| B | HOH827 |
| B | HOH829 |
| B | HOH831 |
| B | HOH833 |
| B | HOH854 |
| site_id | AC5 |
| Number of Residues | 25 |
| Details | binding site for residue FMN B 701 |
| Chain | Residue |
| B | SER65 |
| B | GLN66 |
| B | THR67 |
| B | GLY68 |
| B | THR69 |
| B | ALA70 |
| B | ALA116 |
| B | THR117 |
| B | TYR118 |
| B | GLY119 |
| B | GLY121 |
| B | LEU151 |
| B | GLY152 |
| B | ASN153 |
| B | TYR156 |
| B | PHE158 |
| B | PHE159 |
| B | ASN160 |
| B | ASP186 |
| B | LEU191 |
| B | VAL678 |
| B | FAD700 |
| B | HOH801 |
| B | HOH881 |
| B | HOH951 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | binding site for residue NDP B 702 |
| Chain | Residue |
| B | ARG282 |
| B | GLY535 |
| B | THR536 |
| B | CYS567 |
| B | ARG568 |
| B | SER598 |
| B | ARG599 |
| B | LYS605 |
| B | TYR607 |
| B | GLN609 |
| B | ARG637 |
| B | MET638 |
| B | ASP641 |
| B | HOH844 |
| B | HOH908 |
