6T1R

Pseudo-atomic model of a 16-mer assembly of reduced recombinant human alphaA-crystallin (non domain swapped configuration)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002088	biological_process	lens development in camera-type eye
A	0005198	molecular_function	structural molecule activity
A	0005212	molecular_function	structural constituent of eye lens
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007601	biological_process	visual perception
A	0009408	biological_process	response to heat
A	0032387	biological_process	negative regulation of intracellular transport
A	0032991	cellular_component	protein-containing complex
A	0042026	biological_process	protein refolding
A	0042802	molecular_function	identical protein binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0046872	molecular_function	metal ion binding
A	0050821	biological_process	protein stabilization
A	0051082	molecular_function	unfolded protein binding
B	0002088	biological_process	lens development in camera-type eye
B	0005198	molecular_function	structural molecule activity
B	0005212	molecular_function	structural constituent of eye lens
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0007601	biological_process	visual perception
B	0009408	biological_process	response to heat
B	0032387	biological_process	negative regulation of intracellular transport
B	0032991	cellular_component	protein-containing complex
B	0042026	biological_process	protein refolding
B	0042802	molecular_function	identical protein binding
B	0043066	biological_process	negative regulation of apoptotic process
B	0046872	molecular_function	metal ion binding
B	0050821	biological_process	protein stabilization
B	0051082	molecular_function	unfolded protein binding
C	0002088	biological_process	lens development in camera-type eye
C	0005198	molecular_function	structural molecule activity
C	0005212	molecular_function	structural constituent of eye lens
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0007601	biological_process	visual perception
C	0009408	biological_process	response to heat
C	0032387	biological_process	negative regulation of intracellular transport
C	0032991	cellular_component	protein-containing complex
C	0042026	biological_process	protein refolding
C	0042802	molecular_function	identical protein binding
C	0043066	biological_process	negative regulation of apoptotic process
C	0046872	molecular_function	metal ion binding
C	0050821	biological_process	protein stabilization
C	0051082	molecular_function	unfolded protein binding
D	0002088	biological_process	lens development in camera-type eye
D	0005198	molecular_function	structural molecule activity
D	0005212	molecular_function	structural constituent of eye lens
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0007601	biological_process	visual perception
D	0009408	biological_process	response to heat
D	0032387	biological_process	negative regulation of intracellular transport
D	0032991	cellular_component	protein-containing complex
D	0042026	biological_process	protein refolding
D	0042802	molecular_function	identical protein binding
D	0043066	biological_process	negative regulation of apoptotic process
D	0046872	molecular_function	metal ion binding
D	0050821	biological_process	protein stabilization
D	0051082	molecular_function	unfolded protein binding
E	0002088	biological_process	lens development in camera-type eye
E	0005198	molecular_function	structural molecule activity
E	0005212	molecular_function	structural constituent of eye lens
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0007601	biological_process	visual perception
E	0009408	biological_process	response to heat
E	0032387	biological_process	negative regulation of intracellular transport
E	0032991	cellular_component	protein-containing complex
E	0042026	biological_process	protein refolding
E	0042802	molecular_function	identical protein binding
E	0043066	biological_process	negative regulation of apoptotic process
E	0046872	molecular_function	metal ion binding
E	0050821	biological_process	protein stabilization
E	0051082	molecular_function	unfolded protein binding
F	0002088	biological_process	lens development in camera-type eye
F	0005198	molecular_function	structural molecule activity
F	0005212	molecular_function	structural constituent of eye lens
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0007601	biological_process	visual perception
F	0009408	biological_process	response to heat
F	0032387	biological_process	negative regulation of intracellular transport
F	0032991	cellular_component	protein-containing complex
F	0042026	biological_process	protein refolding
F	0042802	molecular_function	identical protein binding
F	0043066	biological_process	negative regulation of apoptotic process
F	0046872	molecular_function	metal ion binding
F	0050821	biological_process	protein stabilization
F	0051082	molecular_function	unfolded protein binding
G	0002088	biological_process	lens development in camera-type eye
G	0005198	molecular_function	structural molecule activity
G	0005212	molecular_function	structural constituent of eye lens
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0007601	biological_process	visual perception
G	0009408	biological_process	response to heat
G	0032387	biological_process	negative regulation of intracellular transport
G	0032991	cellular_component	protein-containing complex
G	0042026	biological_process	protein refolding
G	0042802	molecular_function	identical protein binding
G	0043066	biological_process	negative regulation of apoptotic process
G	0046872	molecular_function	metal ion binding
G	0050821	biological_process	protein stabilization
G	0051082	molecular_function	unfolded protein binding
H	0002088	biological_process	lens development in camera-type eye
H	0005198	molecular_function	structural molecule activity
H	0005212	molecular_function	structural constituent of eye lens
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0007601	biological_process	visual perception
H	0009408	biological_process	response to heat
H	0032387	biological_process	negative regulation of intracellular transport
H	0032991	cellular_component	protein-containing complex
H	0042026	biological_process	protein refolding
H	0042802	molecular_function	identical protein binding
H	0043066	biological_process	negative regulation of apoptotic process
H	0046872	molecular_function	metal ion binding
H	0050821	biological_process	protein stabilization
H	0051082	molecular_function	unfolded protein binding
I	0002088	biological_process	lens development in camera-type eye
I	0005198	molecular_function	structural molecule activity
I	0005212	molecular_function	structural constituent of eye lens
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0007601	biological_process	visual perception
I	0009408	biological_process	response to heat
I	0032387	biological_process	negative regulation of intracellular transport
I	0032991	cellular_component	protein-containing complex
I	0042026	biological_process	protein refolding
I	0042802	molecular_function	identical protein binding
I	0043066	biological_process	negative regulation of apoptotic process
I	0046872	molecular_function	metal ion binding
I	0050821	biological_process	protein stabilization
I	0051082	molecular_function	unfolded protein binding
J	0002088	biological_process	lens development in camera-type eye
J	0005198	molecular_function	structural molecule activity
J	0005212	molecular_function	structural constituent of eye lens
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0007601	biological_process	visual perception
J	0009408	biological_process	response to heat
J	0032387	biological_process	negative regulation of intracellular transport
J	0032991	cellular_component	protein-containing complex
J	0042026	biological_process	protein refolding
J	0042802	molecular_function	identical protein binding
J	0043066	biological_process	negative regulation of apoptotic process
J	0046872	molecular_function	metal ion binding
J	0050821	biological_process	protein stabilization
J	0051082	molecular_function	unfolded protein binding
K	0002088	biological_process	lens development in camera-type eye
K	0005198	molecular_function	structural molecule activity
K	0005212	molecular_function	structural constituent of eye lens
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0007601	biological_process	visual perception
K	0009408	biological_process	response to heat
K	0032387	biological_process	negative regulation of intracellular transport
K	0032991	cellular_component	protein-containing complex
K	0042026	biological_process	protein refolding
K	0042802	molecular_function	identical protein binding
K	0043066	biological_process	negative regulation of apoptotic process
K	0046872	molecular_function	metal ion binding
K	0050821	biological_process	protein stabilization
K	0051082	molecular_function	unfolded protein binding
L	0002088	biological_process	lens development in camera-type eye
L	0005198	molecular_function	structural molecule activity
L	0005212	molecular_function	structural constituent of eye lens
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0007601	biological_process	visual perception
L	0009408	biological_process	response to heat
L	0032387	biological_process	negative regulation of intracellular transport
L	0032991	cellular_component	protein-containing complex
L	0042026	biological_process	protein refolding
L	0042802	molecular_function	identical protein binding
L	0043066	biological_process	negative regulation of apoptotic process
L	0046872	molecular_function	metal ion binding
L	0050821	biological_process	protein stabilization
L	0051082	molecular_function	unfolded protein binding
M	0002088	biological_process	lens development in camera-type eye
M	0005198	molecular_function	structural molecule activity
M	0005212	molecular_function	structural constituent of eye lens
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0007601	biological_process	visual perception
M	0009408	biological_process	response to heat
M	0032387	biological_process	negative regulation of intracellular transport
M	0032991	cellular_component	protein-containing complex
M	0042026	biological_process	protein refolding
M	0042802	molecular_function	identical protein binding
M	0043066	biological_process	negative regulation of apoptotic process
M	0046872	molecular_function	metal ion binding
M	0050821	biological_process	protein stabilization
M	0051082	molecular_function	unfolded protein binding
N	0002088	biological_process	lens development in camera-type eye
N	0005198	molecular_function	structural molecule activity
N	0005212	molecular_function	structural constituent of eye lens
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0007601	biological_process	visual perception
N	0009408	biological_process	response to heat
N	0032387	biological_process	negative regulation of intracellular transport
N	0032991	cellular_component	protein-containing complex
N	0042026	biological_process	protein refolding
N	0042802	molecular_function	identical protein binding
N	0043066	biological_process	negative regulation of apoptotic process
N	0046872	molecular_function	metal ion binding
N	0050821	biological_process	protein stabilization
N	0051082	molecular_function	unfolded protein binding
O	0002088	biological_process	lens development in camera-type eye
O	0005198	molecular_function	structural molecule activity
O	0005212	molecular_function	structural constituent of eye lens
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0007601	biological_process	visual perception
O	0009408	biological_process	response to heat
O	0032387	biological_process	negative regulation of intracellular transport
O	0032991	cellular_component	protein-containing complex
O	0042026	biological_process	protein refolding
O	0042802	molecular_function	identical protein binding
O	0043066	biological_process	negative regulation of apoptotic process
O	0046872	molecular_function	metal ion binding
O	0050821	biological_process	protein stabilization
O	0051082	molecular_function	unfolded protein binding
P	0002088	biological_process	lens development in camera-type eye
P	0005198	molecular_function	structural molecule activity
P	0005212	molecular_function	structural constituent of eye lens
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0007601	biological_process	visual perception
P	0009408	biological_process	response to heat
P	0032387	biological_process	negative regulation of intracellular transport
P	0032991	cellular_component	protein-containing complex
P	0042026	biological_process	protein refolding
P	0042802	molecular_function	identical protein binding
P	0043066	biological_process	negative regulation of apoptotic process
P	0046872	molecular_function	metal ion binding
P	0050821	biological_process	protein stabilization
P	0051082	molecular_function	unfolded protein binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P02470

Chain	Residue	Details
A	HIS100
D	HIS100
D	GLU102
D	HIS154
E	HIS100
E	GLU102
E	HIS154
F	HIS100
F	GLU102
F	HIS154
G	HIS100
A	GLU102
G	GLU102
G	HIS154
H	HIS100
H	GLU102
H	HIS154
I	HIS100
I	GLU102
I	HIS154
J	HIS100
J	GLU102
A	HIS154
J	HIS154
K	HIS100
K	GLU102
K	HIS154
L	HIS100
L	GLU102
L	HIS154
M	HIS100
M	GLU102
M	HIS154
B	HIS100
N	HIS100
N	GLU102
N	HIS154
O	HIS100
O	GLU102
O	HIS154
P	HIS100
P	GLU102
P	HIS154
B	GLU102
B	HIS154
C	HIS100
C	GLU102
C	HIS154

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:22890888

Chain	Residue	Details
A	HIS107
J	HIS107
K	HIS107
L	HIS107
M	HIS107
N	HIS107
O	HIS107
P	HIS107
B	HIS107
C	HIS107
D	HIS107
E	HIS107
F	HIS107
G	HIS107
H	HIS107
I	HIS107

---

site_id	SWS_FT_FI3
Number of Residues	64
Details	SITE: Susceptible to oxidation

Chain	Residue	Details
A	MET1
C	TYR18
C	TYR34
C	MET138
D	MET1
D	TYR18
D	TYR34
D	MET138
E	MET1
E	TYR18
E	TYR34
A	TYR18
E	MET138
F	MET1
F	TYR18
F	TYR34
F	MET138
G	MET1
G	TYR18
G	TYR34
G	MET138
H	MET1
A	TYR34
H	TYR18
H	TYR34
H	MET138
I	MET1
I	TYR18
I	TYR34
I	MET138
J	MET1
J	TYR18
J	TYR34
A	MET138
J	MET138
K	MET1
K	TYR18
K	TYR34
K	MET138
L	MET1
L	TYR18
L	TYR34
L	MET138
M	MET1
B	MET1
M	TYR18
M	TYR34
M	MET138
N	MET1
N	TYR18
N	TYR34
N	MET138
O	MET1
O	TYR18
O	TYR34
B	TYR18
O	MET138
P	MET1
P	TYR18
P	TYR34
P	MET138
B	TYR34
B	MET138
C	MET1

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	MOD_RES: N-acetylmethionine => ECO:0000269|PubMed:817940

Chain	Residue	Details
A	MET1
J	MET1
K	MET1
L	MET1
M	MET1
N	MET1
O	MET1
P	MET1
B	MET1
C	MET1
D	MET1
E	MET1
F	MET1
G	MET1
H	MET1
I	MET1

---

site_id	SWS_FT_FI5
Number of Residues	64
Details	MOD_RES: Deamidated glutamine; partial => ECO:0000269|PubMed:9068373

Chain	Residue	Details
A	GLN6
C	GLN50
C	GLN90
C	GLN147
D	GLN6
D	GLN50
D	GLN90
D	GLN147
E	GLN6
E	GLN50
E	GLN90
A	GLN50
E	GLN147
F	GLN6
F	GLN50
F	GLN90
F	GLN147
G	GLN6
G	GLN50
G	GLN90
G	GLN147
H	GLN6
A	GLN90
H	GLN50
H	GLN90
H	GLN147
I	GLN6
I	GLN50
I	GLN90
I	GLN147
J	GLN6
J	GLN50
J	GLN90
A	GLN147
J	GLN147
K	GLN6
K	GLN50
K	GLN90
K	GLN147
L	GLN6
L	GLN50
L	GLN90
L	GLN147
M	GLN6
B	GLN6
M	GLN50
M	GLN90
M	GLN147
N	GLN6
N	GLN50
N	GLN90
N	GLN147
O	GLN6
O	GLN50
O	GLN90
B	GLN50
O	GLN147
P	GLN6
P	GLN50
P	GLN90
P	GLN147
B	GLN90
B	GLN147
C	GLN6

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:9068373

Chain	Residue	Details
A	SER45
J	SER45
K	SER45
L	SER45
M	SER45
N	SER45
O	SER45
P	SER45
B	SER45
C	SER45
D	SER45
E	SER45
F	SER45
G	SER45
H	SER45
I	SER45

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22120592, ECO:0000269|PubMed:9655350

Chain	Residue	Details
A	LYS70
J	LYS70
K	LYS70
L	LYS70
M	LYS70
N	LYS70
O	LYS70
P	LYS70
B	LYS70
C	LYS70
D	LYS70
E	LYS70
F	LYS70
G	LYS70
H	LYS70
I	LYS70

---

site_id	SWS_FT_FI8
Number of Residues	16
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22120592

Chain	Residue	Details
A	LYS99
J	LYS99
K	LYS99
L	LYS99
M	LYS99
N	LYS99
O	LYS99
P	LYS99
B	LYS99
C	LYS99
D	LYS99
E	LYS99
F	LYS99
G	LYS99
H	LYS99
I	LYS99

---

site_id	SWS_FT_FI9
Number of Residues	16
Details	MOD_RES: Deamidated asparagine; partial => ECO:0000269|PubMed:8175657, ECO:0000269|PubMed:9068373, ECO:0000269|PubMed:9543632, ECO:0000269|PubMed:9655350

Chain	Residue	Details
A	ASN101
J	ASN101
K	ASN101
L	ASN101
M	ASN101
N	ASN101
O	ASN101
P	ASN101
B	ASN101
C	ASN101
D	ASN101
E	ASN101
F	ASN101
G	ASN101
H	ASN101
I	ASN101

---

site_id	SWS_FT_FI10
Number of Residues	16
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:8175657, ECO:0000269|PubMed:8759518, ECO:0000269|PubMed:9068373

Chain	Residue	Details
A	SER122
J	SER122
K	SER122
L	SER122
M	SER122
N	SER122
O	SER122
P	SER122
B	SER122
C	SER122
D	SER122
E	SER122
F	SER122
G	SER122
H	SER122
I	SER122

---

site_id	SWS_FT_FI11
Number of Residues	16
Details	MOD_RES: Deamidated asparagine; partial => ECO:0000269|PubMed:18754677

Chain	Residue	Details
A	ASN123
J	ASN123
K	ASN123
L	ASN123
M	ASN123
N	ASN123
O	ASN123
P	ASN123
B	ASN123
C	ASN123
D	ASN123
E	ASN123
F	ASN123
G	ASN123
H	ASN123
I	ASN123

---

site_id	SWS_FT_FI12
Number of Residues	16
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
A	SER162
J	SER162
K	SER162
L	SER162
M	SER162
N	SER162
O	SER162
P	SER162
B	SER162
C	SER162
D	SER162
E	SER162
F	SER162
G	SER162
H	SER162
I	SER162

---