Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6T1R

Pseudo-atomic model of a 16-mer assembly of reduced recombinant human alphaA-crystallin (non domain swapped configuration)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002088	biological_process	lens development in camera-type eye
A	0005198	molecular_function	structural molecule activity
A	0005212	molecular_function	structural constituent of eye lens
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007601	biological_process	visual perception
A	0009408	biological_process	response to heat
A	0032387	biological_process	negative regulation of intracellular transport
A	0032991	cellular_component	protein-containing complex
A	0042026	biological_process	protein refolding
A	0042802	molecular_function	identical protein binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0050821	biological_process	protein stabilization
A	0051082	molecular_function	unfolded protein binding
B	0002088	biological_process	lens development in camera-type eye
B	0005198	molecular_function	structural molecule activity
B	0005212	molecular_function	structural constituent of eye lens
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0007601	biological_process	visual perception
B	0009408	biological_process	response to heat
B	0032387	biological_process	negative regulation of intracellular transport
B	0032991	cellular_component	protein-containing complex
B	0042026	biological_process	protein refolding
B	0042802	molecular_function	identical protein binding
B	0043066	biological_process	negative regulation of apoptotic process
B	0050821	biological_process	protein stabilization
B	0051082	molecular_function	unfolded protein binding
C	0002088	biological_process	lens development in camera-type eye
C	0005198	molecular_function	structural molecule activity
C	0005212	molecular_function	structural constituent of eye lens
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0007601	biological_process	visual perception
C	0009408	biological_process	response to heat
C	0032387	biological_process	negative regulation of intracellular transport
C	0032991	cellular_component	protein-containing complex
C	0042026	biological_process	protein refolding
C	0042802	molecular_function	identical protein binding
C	0043066	biological_process	negative regulation of apoptotic process
C	0050821	biological_process	protein stabilization
C	0051082	molecular_function	unfolded protein binding
D	0002088	biological_process	lens development in camera-type eye
D	0005198	molecular_function	structural molecule activity
D	0005212	molecular_function	structural constituent of eye lens
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0007601	biological_process	visual perception
D	0009408	biological_process	response to heat
D	0032387	biological_process	negative regulation of intracellular transport
D	0032991	cellular_component	protein-containing complex
D	0042026	biological_process	protein refolding
D	0042802	molecular_function	identical protein binding
D	0043066	biological_process	negative regulation of apoptotic process
D	0050821	biological_process	protein stabilization
D	0051082	molecular_function	unfolded protein binding
E	0002088	biological_process	lens development in camera-type eye
E	0005198	molecular_function	structural molecule activity
E	0005212	molecular_function	structural constituent of eye lens
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0007601	biological_process	visual perception
E	0009408	biological_process	response to heat
E	0032387	biological_process	negative regulation of intracellular transport
E	0032991	cellular_component	protein-containing complex
E	0042026	biological_process	protein refolding
E	0042802	molecular_function	identical protein binding
E	0043066	biological_process	negative regulation of apoptotic process
E	0050821	biological_process	protein stabilization
E	0051082	molecular_function	unfolded protein binding
F	0002088	biological_process	lens development in camera-type eye
F	0005198	molecular_function	structural molecule activity
F	0005212	molecular_function	structural constituent of eye lens
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0007601	biological_process	visual perception
F	0009408	biological_process	response to heat
F	0032387	biological_process	negative regulation of intracellular transport
F	0032991	cellular_component	protein-containing complex
F	0042026	biological_process	protein refolding
F	0042802	molecular_function	identical protein binding
F	0043066	biological_process	negative regulation of apoptotic process
F	0050821	biological_process	protein stabilization
F	0051082	molecular_function	unfolded protein binding
G	0002088	biological_process	lens development in camera-type eye
G	0005198	molecular_function	structural molecule activity
G	0005212	molecular_function	structural constituent of eye lens
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0007601	biological_process	visual perception
G	0009408	biological_process	response to heat
G	0032387	biological_process	negative regulation of intracellular transport
G	0032991	cellular_component	protein-containing complex
G	0042026	biological_process	protein refolding
G	0042802	molecular_function	identical protein binding
G	0043066	biological_process	negative regulation of apoptotic process
G	0050821	biological_process	protein stabilization
G	0051082	molecular_function	unfolded protein binding
H	0002088	biological_process	lens development in camera-type eye
H	0005198	molecular_function	structural molecule activity
H	0005212	molecular_function	structural constituent of eye lens
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0007601	biological_process	visual perception
H	0009408	biological_process	response to heat
H	0032387	biological_process	negative regulation of intracellular transport
H	0032991	cellular_component	protein-containing complex
H	0042026	biological_process	protein refolding
H	0042802	molecular_function	identical protein binding
H	0043066	biological_process	negative regulation of apoptotic process
H	0050821	biological_process	protein stabilization
H	0051082	molecular_function	unfolded protein binding
I	0002088	biological_process	lens development in camera-type eye
I	0005198	molecular_function	structural molecule activity
I	0005212	molecular_function	structural constituent of eye lens
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0007601	biological_process	visual perception
I	0009408	biological_process	response to heat
I	0032387	biological_process	negative regulation of intracellular transport
I	0032991	cellular_component	protein-containing complex
I	0042026	biological_process	protein refolding
I	0042802	molecular_function	identical protein binding
I	0043066	biological_process	negative regulation of apoptotic process
I	0050821	biological_process	protein stabilization
I	0051082	molecular_function	unfolded protein binding
J	0002088	biological_process	lens development in camera-type eye
J	0005198	molecular_function	structural molecule activity
J	0005212	molecular_function	structural constituent of eye lens
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0007601	biological_process	visual perception
J	0009408	biological_process	response to heat
J	0032387	biological_process	negative regulation of intracellular transport
J	0032991	cellular_component	protein-containing complex
J	0042026	biological_process	protein refolding
J	0042802	molecular_function	identical protein binding
J	0043066	biological_process	negative regulation of apoptotic process
J	0050821	biological_process	protein stabilization
J	0051082	molecular_function	unfolded protein binding
K	0002088	biological_process	lens development in camera-type eye
K	0005198	molecular_function	structural molecule activity
K	0005212	molecular_function	structural constituent of eye lens
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0007601	biological_process	visual perception
K	0009408	biological_process	response to heat
K	0032387	biological_process	negative regulation of intracellular transport
K	0032991	cellular_component	protein-containing complex
K	0042026	biological_process	protein refolding
K	0042802	molecular_function	identical protein binding
K	0043066	biological_process	negative regulation of apoptotic process
K	0050821	biological_process	protein stabilization
K	0051082	molecular_function	unfolded protein binding
L	0002088	biological_process	lens development in camera-type eye
L	0005198	molecular_function	structural molecule activity
L	0005212	molecular_function	structural constituent of eye lens
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0007601	biological_process	visual perception
L	0009408	biological_process	response to heat
L	0032387	biological_process	negative regulation of intracellular transport
L	0032991	cellular_component	protein-containing complex
L	0042026	biological_process	protein refolding
L	0042802	molecular_function	identical protein binding
L	0043066	biological_process	negative regulation of apoptotic process
L	0050821	biological_process	protein stabilization
L	0051082	molecular_function	unfolded protein binding
M	0002088	biological_process	lens development in camera-type eye
M	0005198	molecular_function	structural molecule activity
M	0005212	molecular_function	structural constituent of eye lens
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0007601	biological_process	visual perception
M	0009408	biological_process	response to heat
M	0032387	biological_process	negative regulation of intracellular transport
M	0032991	cellular_component	protein-containing complex
M	0042026	biological_process	protein refolding
M	0042802	molecular_function	identical protein binding
M	0043066	biological_process	negative regulation of apoptotic process
M	0050821	biological_process	protein stabilization
M	0051082	molecular_function	unfolded protein binding
N	0002088	biological_process	lens development in camera-type eye
N	0005198	molecular_function	structural molecule activity
N	0005212	molecular_function	structural constituent of eye lens
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0007601	biological_process	visual perception
N	0009408	biological_process	response to heat
N	0032387	biological_process	negative regulation of intracellular transport
N	0032991	cellular_component	protein-containing complex
N	0042026	biological_process	protein refolding
N	0042802	molecular_function	identical protein binding
N	0043066	biological_process	negative regulation of apoptotic process
N	0050821	biological_process	protein stabilization
N	0051082	molecular_function	unfolded protein binding
O	0002088	biological_process	lens development in camera-type eye
O	0005198	molecular_function	structural molecule activity
O	0005212	molecular_function	structural constituent of eye lens
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0007601	biological_process	visual perception
O	0009408	biological_process	response to heat
O	0032387	biological_process	negative regulation of intracellular transport
O	0032991	cellular_component	protein-containing complex
O	0042026	biological_process	protein refolding
O	0042802	molecular_function	identical protein binding
O	0043066	biological_process	negative regulation of apoptotic process
O	0050821	biological_process	protein stabilization
O	0051082	molecular_function	unfolded protein binding
P	0002088	biological_process	lens development in camera-type eye
P	0005198	molecular_function	structural molecule activity
P	0005212	molecular_function	structural constituent of eye lens
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0007601	biological_process	visual perception
P	0009408	biological_process	response to heat
P	0032387	biological_process	negative regulation of intracellular transport
P	0032991	cellular_component	protein-containing complex
P	0042026	biological_process	protein refolding
P	0042802	molecular_function	identical protein binding
P	0043066	biological_process	negative regulation of apoptotic process
P	0050821	biological_process	protein stabilization
P	0051082	molecular_function	unfolded protein binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1792
Details	Domain: {"description":"sHSP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00285","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	992
Details	Region: {"description":"Required for complex formation with BFSP1 and BFSP2; during homooligomerization, mediates the association of 2 dimers to form a tetramer","evidences":[{"source":"PubMed","id":"28935373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31792453","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P02470","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22890888","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	64
Details	Site: {"description":"Susceptible to oxidation"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	16
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"817940","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	64
Details	Modified residue: {"description":"Deamidated glutamine; partial","evidences":[{"source":"PubMed","id":"9068373","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"9068373","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	16
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22120592","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9655350","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	16
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22120592","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	16
Details	Modified residue: {"description":"Deamidated asparagine; partial","evidences":[{"source":"PubMed","id":"8175657","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9068373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9543632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9655350","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"8175657","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8759518","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9068373","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	16
Details	Modified residue: {"description":"Deamidated asparagine; partial","evidences":[{"source":"PubMed","id":"18754677","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	16
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)