6SYC
Crystal structure of the lysozyme in presence of bromophenol blue at pH 6.5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003796 | molecular_function | lysozyme activity |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0016231 | molecular_function | beta-N-acetylglucosaminidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016998 | biological_process | cell wall macromolecule catabolic process |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0050829 | biological_process | defense response to Gram-negative bacterium |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0051672 | biological_process | obsolete catabolism by organism of cell wall peptidoglycan in other organism |
| B | 0003796 | molecular_function | lysozyme activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0016231 | molecular_function | beta-N-acetylglucosaminidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0016998 | biological_process | cell wall macromolecule catabolic process |
| B | 0031640 | biological_process | killing of cells of another organism |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0050829 | biological_process | defense response to Gram-negative bacterium |
| B | 0050830 | biological_process | defense response to Gram-positive bacterium |
| B | 0051672 | biological_process | obsolete catabolism by organism of cell wall peptidoglycan in other organism |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue NA A 201 |
| Chain | Residue |
| A | SER60 |
| A | CYS64 |
| A | ASN65 |
| A | ASP66 |
| A | THR69 |
| A | SER72 |
| A | HOH360 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue LYE A 202 |
| Chain | Residue |
| A | LYE203 |
| B | TYR20 |
| B | LYS97 |
| B | SER100 |
| B | ARG128 |
| B | LYE203 |
| B | LYE205 |
| B | HOH322 |
| A | ARG45 |
| A | THR47 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue LYE A 203 |
| Chain | Residue |
| A | GLY16 |
| A | TYR20 |
| A | ARG21 |
| A | ARG45 |
| A | LYS96 |
| A | LYE202 |
| A | HOH308 |
| B | ARG45 |
| B | LYE206 |
| B | LYE208 |
| B | HOH356 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue IMD A 204 |
| Chain | Residue |
| A | ASN44 |
| A | ASN46 |
| A | ASP52 |
| A | GLN57 |
| B | ARG21 |
| B | LYE203 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 201 |
| Chain | Residue |
| B | SER60 |
| B | CYS64 |
| B | SER72 |
| B | ARG73 |
| B | HOH335 |
| B | HOH346 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 202 |
| Chain | Residue |
| B | HIS15 |
| B | ASP87 |
| B | ILE88 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | binding site for residue LYE B 203 |
| Chain | Residue |
| A | THR47 |
| A | ARG128 |
| A | LYE202 |
| A | IMD204 |
| B | GLY16 |
| B | TYR20 |
| B | ARG21 |
| B | ARG45 |
| B | ASN46 |
| B | ASN93 |
| B | LYS96 |
| B | LYE204 |
| B | LYE208 |
| B | HOH304 |
| B | HOH360 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue LYE B 204 |
| Chain | Residue |
| A | LEU75 |
| A | ASN77 |
| A | ASN93 |
| B | THR89 |
| B | ASN93 |
| B | LYE203 |
| B | LYE208 |
| B | HOH313 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | binding site for residue LYE B 205 |
| Chain | Residue |
| A | LYE202 |
| B | GLY4 |
| B | ARG5 |
| B | CYS6 |
| B | GLU7 |
| B | LEU75 |
| B | LYS97 |
| B | GLY126 |
| B | ARG128 |
| B | LYE206 |
| B | HOH342 |
| B | HOH374 |
| site_id | AD1 |
| Number of Residues | 11 |
| Details | binding site for residue LYE B 206 |
| Chain | Residue |
| A | ARG14 |
| A | HIS15 |
| A | GLY16 |
| A | THR89 |
| A | ASN93 |
| A | LYS96 |
| A | LYE203 |
| A | HOH306 |
| B | ASN77 |
| B | ARG128 |
| B | LYE205 |
| site_id | AD2 |
| Number of Residues | 12 |
| Details | binding site for residue LYE B 207 |
| Chain | Residue |
| B | HOH314 |
| B | HOH328 |
| A | GLY4 |
| A | ARG5 |
| A | CYS6 |
| A | GLU7 |
| A | LEU75 |
| A | ASN77 |
| A | ARG128 |
| A | HOH318 |
| B | ARG14 |
| B | LYE208 |
| site_id | AD3 |
| Number of Residues | 12 |
| Details | binding site for residue LYE B 208 |
| Chain | Residue |
| A | LYS97 |
| A | SER100 |
| A | ARG128 |
| A | LYE203 |
| B | HIS15 |
| B | THR47 |
| B | THR89 |
| B | ASN93 |
| B | LYE203 |
| B | LYE204 |
| B | LYE207 |
| B | HOH348 |
Functional Information from PROSITE/UniProt
| site_id | PS00128 |
| Number of Residues | 19 |
| Details | GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC |
| Chain | Residue | Details |
| A | CYS76-CYS94 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 128 |
| Details | Domain: {"description":"C-type lysozyme","evidences":[{"source":"PROSITE-ProRule","id":"PRU00680","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 203 |
| Chain | Residue | Details |
| A | GLU35 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | ASN46 | |
| A | ASP48 | |
| A | SER50 | |
| A | ASP52 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction |
| A | ASN59 |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 203 |
| Chain | Residue | Details |
| B | GLU35 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | ASN46 | |
| B | ASP48 | |
| B | SER50 | |
| B | ASP52 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction |
| B | ASN59 |
