6SXG

Crystal Structure of the Voltage-Gated Sodium Channel NavMs in complex with 4-hydroxytamoxifen (2.4 Angstrom resolution)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001518	cellular_component	voltage-gated sodium channel complex
A	0005216	molecular_function	monoatomic ion channel activity
A	0005248	molecular_function	voltage-gated sodium channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0035725	biological_process	sodium ion transmembrane transport
A	0055085	biological_process	transmembrane transport
A	0086010	biological_process	membrane depolarization during action potential

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue NA A 301

Chain	Residue
A	NA302
A	NA302
A	NA302
A	NA302

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site_id	AC2
Number of Residues	8
Details	binding site for residue NA A 302

Chain	Residue
A	NA303
A	NA303
A	NA303
A	NA301
A	NA301
A	NA301
A	NA301
A	NA303

---

site_id	AC3
Number of Residues	4
Details	binding site for residue NA A 303

Chain	Residue
A	NA302
A	NA302
A	NA302
A	NA302

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site_id	AC4
Number of Residues	10
Details	binding site for residue 2CV A 304

Chain	Residue
A	GLU159
A	SER165
A	LYS166
A	TYR169
A	MET189
A	PRO193
A	TRP196
A	2CV309
A	HOH402
A	HOH415

---

site_id	AC5
Number of Residues	8
Details	binding site for residue OHT A 305

Chain	Residue
A	GLY130
A	ASP220
A	MET222
A	LYS226
A	ILE241
A	LEU245
A	LEU246
A	OHT307

---

site_id	AC6
Number of Residues	10
Details	binding site for residue 12P A 306

Chain	Residue
A	PHE105
A	MET108
A	MET148
A	TYR153
A	HIS192
A	PRO193
A	ASN194
A	ALA195
A	VAL197
A	PHE198

---

site_id	AC7
Number of Residues	8
Details	binding site for residue OHT A 307

Chain	Residue
A	GLY130
A	SER133
A	ASP220
A	ALA223
A	LYS226
A	SER242
A	OHT305
A	HOH409

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site_id	AC8
Number of Residues	1
Details	binding site for residue 2CV A 308

Chain	Residue
A	MET175

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site_id	AC9
Number of Residues	3
Details	binding site for residue 2CV A 309

Chain	Residue
A	SER165
A	ASN194
A	2CV304

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