6STF

Human Rab8a phosphorylated at Ser111 in complex with GDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
E	0003924	molecular_function	GTPase activity
E	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue GDP A 901

Chain	Residue
A	SER17
A	ARG71
A	ASN121
A	LYS122
A	ASP124
A	VAL125
A	SER151
A	ALA152
A	LYS153
A	MG902
A	HOH1003
A	GLY18
A	HOH1005
A	HOH1006
A	VAL19
A	GLY20
A	LYS21
A	THR22
A	CYS23
A	PHE33
A	ASN34

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 902

Chain	Residue
A	THR22
A	GDP901
A	HOH1003
A	HOH1005
A	HOH1006
A	HOH1008

---

site_id	AC3
Number of Residues	22
Details	binding site for residue GDP B 901

Chain	Residue
B	GLY18
B	VAL19
B	GLY20
B	LYS21
B	THR22
B	CYS23
B	PHE33
B	ASN34
B	ASN121
B	LYS122
B	ASP124
B	VAL125
B	SER151
B	ALA152
B	LYS153
B	MG902
B	HOH1002
B	HOH1003
B	HOH1006
C	GLU51
C	GLY54
C	ARG56

---

site_id	AC4
Number of Residues	6
Details	binding site for residue MG B 902

Chain	Residue
B	THR22
B	GDP901
B	HOH1002
B	HOH1003
B	HOH1006
B	HOH1008

---

site_id	AC5
Number of Residues	20
Details	binding site for residue GDP C 901

Chain	Residue
C	SER17
C	GLY18
C	VAL19
C	GLY20
C	LYS21
C	THR22
C	CYS23
C	PHE33
C	ASN121
C	LYS122
C	ASP124
C	VAL125
C	SER151
C	ALA152
C	LYS153
C	MG902
C	HOH1002
C	HOH1004
C	HOH1005
C	HOH1006

---

site_id	AC6
Number of Residues	6
Details	binding site for residue MG C 902

Chain	Residue
C	THR22
C	GDP901
C	HOH1001
C	HOH1002
C	HOH1004
C	HOH1007

---

site_id	AC7
Number of Residues	22
Details	binding site for residue GDP D 901

Chain	Residue
D	HOH1004
E	GLU51
E	GLY54
E	ARG56
D	GLY18
D	VAL19
D	GLY20
D	LYS21
D	THR22
D	CYS23
D	PHE33
D	ASN34
D	ASN121
D	LYS122
D	ASP124
D	VAL125
D	SER151
D	ALA152
D	LYS153
D	MG902
D	HOH1001
D	HOH1003

---

site_id	AC8
Number of Residues	6
Details	binding site for residue MG D 902

Chain	Residue
D	THR22
D	GDP901
D	HOH1001
D	HOH1003
D	HOH1004
D	HOH1006

---

site_id	AC9
Number of Residues	17
Details	binding site for residue GDP E 901

Chain	Residue
E	GLY18
E	VAL19
E	GLY20
E	LYS21
E	THR22
E	CYS23
E	PHE33
E	ASN121
E	LYS122
E	ASP124
E	VAL125
E	SER151
E	ALA152
E	LYS153
E	MG902
E	HOH1003
E	HOH1006

---

site_id	AD1
Number of Residues	7
Details	binding site for residue MG E 902

Chain	Residue
E	THR22
E	ASP63
E	GDP901
E	HOH1002
E	HOH1003
E	HOH1006
E	HOH1008

---

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. LLLiGDSGVGKtcV

Chain	Residue	Details
A	LEU11-VAL24

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	BINDING: BINDING => ECO:0000269|PubMed:27552051, ECO:0007744|PDB:5SZI

Chain	Residue	Details
A	SER17
D	SER17
D	ASN34
D	ASN121
E	SER17
E	ASN34
E	ASN121
A	ASN34
A	ASN121
B	SER17
B	ASN34
B	ASN121
C	SER17
C	ASN34
C	ASN121

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9H0U4, ECO:0000269|PubMed:27552051, ECO:0007744|PDB:5SZI

Chain	Residue	Details
A	ASP63
E	ALA152
A	ALA152
B	ASP63
B	ALA152
C	ASP63
C	ALA152
D	ASP63
D	ALA152
E	ASP63

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	MOD_RES: Phosphothreonine; by LRRK2 => ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148

Chain	Residue	Details
A	THR72
B	THR72
C	THR72
D	THR72
E	THR72

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