6SSW

Crystal structure of Human Microsomal Glutathione S-Transferase 2 in complex with an Inhibitor Glutathione sulfonic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0004464	molecular_function	leukotriene-C4 synthase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0005515	molecular_function	protein binding
A	0005635	cellular_component	nuclear envelope
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006691	biological_process	leukotriene metabolic process
A	0006750	biological_process	glutathione biosynthetic process
A	0008047	molecular_function	enzyme activator activity
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0016829	molecular_function	lyase activity
A	0019370	biological_process	leukotriene biosynthetic process
A	0032496	biological_process	response to lipopolysaccharide
A	0042802	molecular_function	identical protein binding
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0043295	molecular_function	glutathione binding
A	0046394	biological_process	carboxylic acid biosynthetic process
A	0046466	biological_process	membrane lipid catabolic process
A	0050729	biological_process	positive regulation of inflammatory response
A	0098869	biological_process	cellular oxidant detoxification
B	0004364	molecular_function	glutathione transferase activity
B	0004464	molecular_function	leukotriene-C4 synthase activity
B	0004602	molecular_function	glutathione peroxidase activity
B	0005515	molecular_function	protein binding
B	0005635	cellular_component	nuclear envelope
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0006691	biological_process	leukotriene metabolic process
B	0006750	biological_process	glutathione biosynthetic process
B	0008047	molecular_function	enzyme activator activity
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0016829	molecular_function	lyase activity
B	0019370	biological_process	leukotriene biosynthetic process
B	0032496	biological_process	response to lipopolysaccharide
B	0042802	molecular_function	identical protein binding
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0043295	molecular_function	glutathione binding
B	0046394	biological_process	carboxylic acid biosynthetic process
B	0046466	biological_process	membrane lipid catabolic process
B	0050729	biological_process	positive regulation of inflammatory response
B	0098869	biological_process	cellular oxidant detoxification
C	0004364	molecular_function	glutathione transferase activity
C	0004464	molecular_function	leukotriene-C4 synthase activity
C	0004602	molecular_function	glutathione peroxidase activity
C	0005515	molecular_function	protein binding
C	0005635	cellular_component	nuclear envelope
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005886	cellular_component	plasma membrane
C	0006629	biological_process	lipid metabolic process
C	0006691	biological_process	leukotriene metabolic process
C	0006750	biological_process	glutathione biosynthetic process
C	0008047	molecular_function	enzyme activator activity
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016740	molecular_function	transferase activity
C	0016829	molecular_function	lyase activity
C	0019370	biological_process	leukotriene biosynthetic process
C	0032496	biological_process	response to lipopolysaccharide
C	0042802	molecular_function	identical protein binding
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0043295	molecular_function	glutathione binding
C	0046394	biological_process	carboxylic acid biosynthetic process
C	0046466	biological_process	membrane lipid catabolic process
C	0050729	biological_process	positive regulation of inflammatory response
C	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue GTS A 201

Chain	Residue
A	ARG51
B	ARG30
B	PHE50
B	GLN53
A	ASN55
A	GLU58
A	TYR93
A	TYR97
A	ARG104
A	PHE108
B	ALA23
B	GLY27

---

site_id	AC2
Number of Residues	12
Details	binding site for residue GTS B 201

Chain	Residue
B	ARG51
B	ASN55
B	GLU58
B	TYR93
B	TYR97
B	ARG104
B	PHE108
C	ALA23
C	VAL26
C	ARG30
C	PHE50
C	GLN53

---

site_id	AC3
Number of Residues	13
Details	binding site for residue GTS C 201

Chain	Residue
A	ALA23
A	VAL26
A	ARG30
A	PHE50
A	GLN53
C	ARG51
C	ASN55
C	GLU58
C	PHE59
C	TYR93
C	TYR97
C	ARG104
C	PHE108

---

Functional Information from PROSITE/UniProt

site_id	PS01297
Number of Residues	15
Details	FLAP_GST2_LTC4S FLAP/GST2/LTC4S family signature. GspeFERVFrAQqNC

Chain	Residue	Details
A	GLY42-CYS56

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	180
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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