Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6SSS

Crystal structure of Human Microsomal Glutathione S-Transferase 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0004464	molecular_function	leukotriene-C4 synthase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0005515	molecular_function	protein binding
A	0005635	cellular_component	nuclear envelope
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006691	biological_process	leukotriene metabolic process
A	0006750	biological_process	glutathione biosynthetic process
A	0008047	molecular_function	enzyme activator activity
A	0010243	biological_process	response to organonitrogen compound
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0016829	molecular_function	lyase activity
A	0019370	biological_process	leukotriene biosynthetic process
A	0032496	biological_process	response to lipopolysaccharide
A	0042802	molecular_function	identical protein binding
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0043295	molecular_function	glutathione binding
A	0046466	biological_process	membrane lipid catabolic process
A	0050729	biological_process	positive regulation of inflammatory response
A	0098869	biological_process	cellular oxidant detoxification
B	0004364	molecular_function	glutathione transferase activity
B	0004464	molecular_function	leukotriene-C4 synthase activity
B	0004602	molecular_function	glutathione peroxidase activity
B	0005515	molecular_function	protein binding
B	0005635	cellular_component	nuclear envelope
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0006691	biological_process	leukotriene metabolic process
B	0006750	biological_process	glutathione biosynthetic process
B	0008047	molecular_function	enzyme activator activity
B	0010243	biological_process	response to organonitrogen compound
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0016829	molecular_function	lyase activity
B	0019370	biological_process	leukotriene biosynthetic process
B	0032496	biological_process	response to lipopolysaccharide
B	0042802	molecular_function	identical protein binding
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0043295	molecular_function	glutathione binding
B	0046466	biological_process	membrane lipid catabolic process
B	0050729	biological_process	positive regulation of inflammatory response
B	0098869	biological_process	cellular oxidant detoxification
C	0004364	molecular_function	glutathione transferase activity
C	0004464	molecular_function	leukotriene-C4 synthase activity
C	0004602	molecular_function	glutathione peroxidase activity
C	0005515	molecular_function	protein binding
C	0005635	cellular_component	nuclear envelope
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005886	cellular_component	plasma membrane
C	0006629	biological_process	lipid metabolic process
C	0006691	biological_process	leukotriene metabolic process
C	0006750	biological_process	glutathione biosynthetic process
C	0008047	molecular_function	enzyme activator activity
C	0010243	biological_process	response to organonitrogen compound
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016740	molecular_function	transferase activity
C	0016829	molecular_function	lyase activity
C	0019370	biological_process	leukotriene biosynthetic process
C	0032496	biological_process	response to lipopolysaccharide
C	0042802	molecular_function	identical protein binding
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0043295	molecular_function	glutathione binding
C	0046466	biological_process	membrane lipid catabolic process
C	0050729	biological_process	positive regulation of inflammatory response
C	0098869	biological_process	cellular oxidant detoxification
D	0004364	molecular_function	glutathione transferase activity
D	0004464	molecular_function	leukotriene-C4 synthase activity
D	0004602	molecular_function	glutathione peroxidase activity
D	0005515	molecular_function	protein binding
D	0005635	cellular_component	nuclear envelope
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005886	cellular_component	plasma membrane
D	0006629	biological_process	lipid metabolic process
D	0006691	biological_process	leukotriene metabolic process
D	0006750	biological_process	glutathione biosynthetic process
D	0008047	molecular_function	enzyme activator activity
D	0010243	biological_process	response to organonitrogen compound
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0016740	molecular_function	transferase activity
D	0016829	molecular_function	lyase activity
D	0019370	biological_process	leukotriene biosynthetic process
D	0032496	biological_process	response to lipopolysaccharide
D	0042802	molecular_function	identical protein binding
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0043295	molecular_function	glutathione binding
D	0046466	biological_process	membrane lipid catabolic process
D	0050729	biological_process	positive regulation of inflammatory response
D	0098869	biological_process	cellular oxidant detoxification
E	0004364	molecular_function	glutathione transferase activity
E	0004464	molecular_function	leukotriene-C4 synthase activity
E	0004602	molecular_function	glutathione peroxidase activity
E	0005515	molecular_function	protein binding
E	0005635	cellular_component	nuclear envelope
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005886	cellular_component	plasma membrane
E	0006629	biological_process	lipid metabolic process
E	0006691	biological_process	leukotriene metabolic process
E	0006750	biological_process	glutathione biosynthetic process
E	0008047	molecular_function	enzyme activator activity
E	0010243	biological_process	response to organonitrogen compound
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0016740	molecular_function	transferase activity
E	0016829	molecular_function	lyase activity
E	0019370	biological_process	leukotriene biosynthetic process
E	0032496	biological_process	response to lipopolysaccharide
E	0042802	molecular_function	identical protein binding
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0043295	molecular_function	glutathione binding
E	0046466	biological_process	membrane lipid catabolic process
E	0050729	biological_process	positive regulation of inflammatory response
E	0098869	biological_process	cellular oxidant detoxification
F	0004364	molecular_function	glutathione transferase activity
F	0004464	molecular_function	leukotriene-C4 synthase activity
F	0004602	molecular_function	glutathione peroxidase activity
F	0005515	molecular_function	protein binding
F	0005635	cellular_component	nuclear envelope
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005886	cellular_component	plasma membrane
F	0006629	biological_process	lipid metabolic process
F	0006691	biological_process	leukotriene metabolic process
F	0006750	biological_process	glutathione biosynthetic process
F	0008047	molecular_function	enzyme activator activity
F	0010243	biological_process	response to organonitrogen compound
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0016740	molecular_function	transferase activity
F	0016829	molecular_function	lyase activity
F	0019370	biological_process	leukotriene biosynthetic process
F	0032496	biological_process	response to lipopolysaccharide
F	0042802	molecular_function	identical protein binding
F	0043231	cellular_component	intracellular membrane-bounded organelle
F	0043295	molecular_function	glutathione binding
F	0046466	biological_process	membrane lipid catabolic process
F	0050729	biological_process	positive regulation of inflammatory response
F	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 A 201

Chain	Residue
A	ARG51
A	ASN55
A	TYR93
A	TYR97
A	ARG104

site_id	AC2
Number of Residues	4
Details	binding site for residue NA A 202

Chain	Residue
A	GLN18
A	PHE22
A	HIS91
A	TRP95

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 B 201

Chain	Residue
B	ARG51
B	TYR93
B	TYR97
C	ARG30

site_id	AC4
Number of Residues	7
Details	binding site for residue M88 B 202

Chain	Residue
B	ARG109
B	GLY113
B	ILE114
B	LEU117
E	LEU124
E	ASN128
E	LEU131

site_id	AC5
Number of Residues	4
Details	binding site for residue M88 B 203

Chain	Residue
B	ASN128
F	CYS81
F	LEU84
F	TYR88

site_id	AC6
Number of Residues	2
Details	binding site for residue M88 B 204

Chain	Residue
B	ALA116
B	THR119

site_id	AC7
Number of Residues	1
Details	binding site for residue M88 B 205

Chain	Residue
B	PHE78

site_id	AC8
Number of Residues	6
Details	binding site for residue SO4 C 201

Chain	Residue
A	ARG30
C	ARG51
C	ASN55
C	TYR93
C	TYR97
C	ARG104

site_id	AC9
Number of Residues	3
Details	binding site for residue NA C 202

Chain	Residue
B	PRO61
C	VAL57
C	PRO61

site_id	AD1
Number of Residues	3
Details	binding site for residue GOL C 203

Chain	Residue
C	TYR73
C	PHE74
C	ASN128

site_id	AD2
Number of Residues	6
Details	binding site for residue SO4 D 201

Chain	Residue
D	ARG51
D	ASN55
D	TYR93
D	TYR97
D	ARG104
E	ARG30

site_id	AD3
Number of Residues	3
Details	binding site for residue NA D 202

Chain	Residue
D	GLN18
D	HIS91
D	TRP95

site_id	AD4
Number of Residues	6
Details	binding site for residue SO4 E 201

Chain	Residue
E	ARG51
E	ASN55
E	TYR93
E	TYR97
E	ARG104
F	ARG30

site_id	AD5
Number of Residues	4
Details	binding site for residue NA E 202

Chain	Residue
E	GLN18
E	PHE22
E	HIS91
E	TRP95

site_id	AD6
Number of Residues	2
Details	binding site for residue GOL E 203

Chain	Residue
E	LEU131
E	ASP132

site_id	AD7
Number of Residues	3
Details	binding site for residue SCN E 204

Chain	Residue
E	GLN18
E	GLN19
E	K205

site_id	AD8
Number of Residues	5
Details	binding site for residue K E 205

Chain	Residue
E	CYS56
E	PHE59
E	TYR60
E	TYR86
E	SCN204

site_id	AD9
Number of Residues	4
Details	binding site for residue SO4 F 201

Chain	Residue
D	ARG30
F	ARG51
F	ASN55
F	TYR97

site_id	AE1
Number of Residues	4
Details	binding site for residue M88 F 202

Chain	Residue
B	LEU84
B	TYR88
F	ALA127
F	ASN128

site_id	AE2
Number of Residues	1
Details	binding site for residue NA F 203

Chain	Residue
F	GLN18

Functional Information from PROSITE/UniProt

site_id	PS01297
Number of Residues	15
Details	FLAP_GST2_LTC4S FLAP/GST2/LTC4S family signature. GspeFERVFrAQqNC

Chain	Residue	Details
A	GLY42-CYS56

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	360
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ILE6-VAL26
D	ILE6-VAL26
D	PHE59-ALA79
D	SER111-LEU131
E	ILE6-VAL26
E	PHE59-ALA79
E	SER111-LEU131
F	ILE6-VAL26
F	PHE59-ALA79
F	SER111-LEU131
A	PHE59-ALA79
A	SER111-LEU131
B	ILE6-VAL26
B	PHE59-ALA79
B	SER111-LEU131
C	ILE6-VAL26
C	PHE59-ALA79
C	SER111-LEU131

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)