6SPW
Structure of protein kinase CK2 catalytic subunit with the CK2beta-competitive bisubstrate inhibitor ARC3140
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005956 | cellular_component | protein kinase CK2 complex |
| A | 0006302 | biological_process | double-strand break repair |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006915 | biological_process | apoptotic process |
| A | 0006974 | biological_process | DNA damage response |
| A | 0007165 | biological_process | signal transduction |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0016055 | biological_process | Wnt signaling pathway |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016605 | cellular_component | PML body |
| A | 0017148 | biological_process | negative regulation of translation |
| A | 0018105 | biological_process | peptidyl-serine phosphorylation |
| A | 0018107 | biological_process | peptidyl-threonine phosphorylation |
| A | 0030177 | biological_process | positive regulation of Wnt signaling pathway |
| A | 0030307 | biological_process | positive regulation of cell growth |
| A | 0031519 | cellular_component | PcG protein complex |
| A | 0032435 | biological_process | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043154 | biological_process | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| A | 0045732 | biological_process | positive regulation of protein catabolic process |
| A | 0048511 | biological_process | rhythmic process |
| A | 0050821 | biological_process | protein stabilization |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0051879 | molecular_function | Hsp90 protein binding |
| A | 0061077 | biological_process | chaperone-mediated protein folding |
| A | 0070822 | cellular_component | Sin3-type complex |
| A | 0075342 | biological_process | symbiont-mediated disruption of host cell PML body |
| A | 0106310 | molecular_function | protein serine kinase activity |
| A | 1905337 | biological_process | positive regulation of aggrephagy |
| A | 1905818 | biological_process | regulation of chromosome separation |
| A | 2000042 | biological_process | negative regulation of double-strand break repair via homologous recombination |
| A | 2001234 | biological_process | negative regulation of apoptotic signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 401 |
| Chain | Residue |
| A | TRP33 |
| A | THR326 |
| A | HOH654 |
| A | HOH662 |
| A | HOH674 |
| A | HOH709 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue A0Z B 101 |
| Chain | Residue |
| A | PHE113 |
| A | GLU114 |
| A | VAL116 |
| A | LYS158 |
| A | ASP175 |
| A | HOH737 |
| A | HOH769 |
| B | DAS2 |
| B | HOH201 |
| A | ARG47 |
| A | GLY48 |
| A | VAL53 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide DAS C 2 and ASP C 3 |
| Chain | Residue |
| A | HOH572 |
| C | ASP4 |
| C | A0Z101 |
| C | HOH201 |
| D | A0Z101 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide A0Z C 101 and DAS C 2 |
| Chain | Residue |
| A | TYR39 |
| A | LEU41 |
| A | LYS44 |
| A | VAL101 |
| A | THR108 |
| A | HIS236 |
| A | ARG244 |
| A | HOH572 |
| A | HOH575 |
| A | HOH725 |
| A | HOH780 |
| C | ASP3 |
| C | HOH201 |
| D | A0Z101 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide DAS D 2 and ASP D 3 |
| Chain | Residue |
| A | ASP266 |
| A | PRO267 |
| A | ARG268 |
| D | ASP4 |
| D | A0Z101 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide A0Z D 101 and DAS D 2 |
| Chain | Residue |
| A | LEU41 |
| A | VAL42 |
| A | ASP237 |
| A | TYR239 |
| A | ASP240 |
| A | ASP266 |
| A | PRO267 |
| A | ARG268 |
| A | ILE272 |
| C | DAS2 |
| C | A0Z101 |
| C | HOH203 |
| D | ASP3 |
| D | HOH202 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK |
| Chain | Residue | Details |
| A | LEU45-LYS68 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI |
| Chain | Residue | Details |
| A | ILE152-ILE164 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | ASP156 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | LYS68 | |
| A | LEU45 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by CDK1 => ECO:0000269|PubMed:7592773 |
| Chain | Residue | Details |
| A | THR360 | |
| A | THR344 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:7592773 |
| Chain | Residue | Details |
| A | SER362 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:7592773, ECO:0007744|PubMed:18691976 |
| Chain | Residue | Details |
| A | SER370 |
