6SPR

Structure of the Escherichia coli methionyl-tRNA synthetase variant VI298 complexed with beta-methionine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004825	molecular_function	methionine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006431	biological_process	methionyl-tRNA aminoacylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 701

Chain	Residue
A	CYS145
A	CYS148
A	CYS158
A	CYS161

---

site_id	AC2
Number of Residues	13
Details	binding site for residue B3M A 702

Chain	Residue
A	PRO257
A	TYR260
A	HIS301
A	HOH801
A	HOH802
A	HOH805
A	HOH872
A	HOH1259
A	LEU13
A	TYR15
A	ASP52
A	TRP253
A	ALA256

---

site_id	AC3
Number of Residues	7
Details	binding site for residue CIT A 703

Chain	Residue
A	GLN63
A	LYS132
A	HOH843
A	HOH974
A	HOH988
A	HOH993
A	HOH1086

---

site_id	AC4
Number of Residues	10
Details	binding site for residue CIT A 704

Chain	Residue
A	PRO57
A	PRO137
A	ARG233
A	TYR251
A	HOH804
A	HOH814
A	HOH819
A	HOH850
A	HOH1238
A	HOH1398

---

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL A 705

Chain	Residue
A	GLN458
A	ARG469
A	ASP472
A	HOH844
A	HOH920
A	HOH1010

---

site_id	AC6
Number of Residues	8
Details	binding site for residue GOL A 706

Chain	Residue
A	TYR128
A	GLN458
A	ALA459
A	ARG469
A	HOH806
A	HOH807
A	HOH1010
A	HOH1081

---

site_id	AC7
Number of Residues	5
Details	binding site for residue GOL A 707

Chain	Residue
A	PHE300
A	PHE304
A	HOH840
A	HOH1134
A	HOH1318

---

site_id	AC8
Number of Residues	4
Details	binding site for residue GOL A 708

Chain	Residue
A	HIS98
A	SER99
A	GLU100
A	ARG103

---

Functional Information from PROSITE/UniProt

site_id	PS00178
Number of Residues	12
Details	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PyaNGsIHLGHM

Chain	Residue	Details
A	PRO14-MET25

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Motif: {"description":"'HIGH' region","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Motif: {"description":"'KMSKS' region","evidences":[{"source":"PubMed","id":"7932711","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11243794","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12946347","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F4L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PG2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10600385","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11243794","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12946347","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8515465","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8515466","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F4L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MEA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MED","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P7P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PFV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PFY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QQT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"2254937","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---